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Cancer Immunology, Immunotherapy

Erschienen in:

09.10.2018 | Focussed Research Review

Opposing roles of eosinophils in cancer

verfasst von: Sonja C. S. Simon, Jochen Utikal, Viktor Umansky

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 5/2019

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Abstract

Eosinophils are a subset of granulocytes mostly known for their ability to combat parasites and induce allergy. Although they were described to be related to cancer more than 100 years ago, their role in tumors is still undefined. Recent observations revealed that they display regulatory functions towards other immune cell subsets in the tumor microenvironment or direct cytotoxic functions against tumor cells, leading to either antitumor or protumor effects. This paradoxical role of eosinophils was suggested to be dependent on the different factors in the TME. In addition, the clinical relevance of these cells has been recently addressed. In most cases, the accumulation of eosinophils both in the tumor tissue, called tumor-associated tissue eosinophilia, and in the peripheral blood were reported to be prognostic markers for a better outcome of cancer patients. In immunotherapy of cancer, particularly in therapy with immune checkpoint inhibitors, eosinophils were even shown to be a potential predictive marker for a beneficial clinical response. A better understanding of their role in cancer progression will help to establish them as prognostic and predictive markers and to design strategies for targeting eosinophils.

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Titel: Opposing roles of eosinophils in cancer
verfasst von: Sonja C. S. Simon
Jochen Utikal
Viktor Umansky
Publikationsdatum: 09.10.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 5/2019
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-018-2255-4

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Springer Medizin

Opposing roles of eosinophils in cancer

Abstract

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