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22.05.2019 | Original Paper

Optical coherence tomography angiography analysis of macular vessel density before and after anti-VEGF therapy in eyes with diabetic retinopathy

verfasst von: Osama A. Sorour, Almyr S. Sabrosa, A. Yasin Alibhai, Malvika Arya, Akihiro Ishibazawa, Andre J. Witkin, Caroline R. Baumal, Jay S. Duker, Nadia K. Waheed

Erschienen in: International Ophthalmology | Ausgabe 10/2019

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Abstract

Purpose

To evaluate changes in macular vessel density following intravitreal anti-VEGF injection in patients with diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR).

Methods

In this retrospective case series, optical coherence tomography angiography (OCTA) images from 55 eyes of 35 patients with either DME (46 eyes) or PDR (9 eyes) were included. Macular capillary vessel density at the level of the superficial retinal capillary plexus (SCP), deep retinal capillary plexus (DCP) and total retinal capillary plexus (TCP) before and after anti-VEGF treatment was calculated. Longitudinal changes in vessel density following serial anti-VEGF treatment were analyzed in a subset of eyes.

Results

Vessel density in the SCP, DCP or TCP was not found to be significantly different after one, two or three intravitreal injections (p > 0.05 for all time points). Subgroup analysis revealed no significant change in the DME and PDR subgroups (all p > 0.05). Multivariate analysis revealed no effect of type of injected anti-VEGF agent or presence of previous treatment on VD measurements (all p > 0.05). There was no correlation between the anatomic response of DME to treatment and VD measurements.

Conclusions

In this study, macular vessel density remained statistically unchanged following up to three intravitreal injections of any anti-VEGF agent. This indicates that there may not be an early effect of anti-VEGF treatment on macular vessel density and its effect on macular perfusion may not be a direct change in microvascular flow.

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Titel: Optical coherence tomography angiography analysis of macular vessel density before and after anti-VEGF therapy in eyes with diabetic retinopathy
verfasst von: Osama A. Sorour
Almyr S. Sabrosa
A. Yasin Alibhai
Malvika Arya
Akihiro Ishibazawa
Andre J. Witkin
Caroline R. Baumal
Jay S. Duker
Nadia K. Waheed
Publikationsdatum: 22.05.2019
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 10/2019
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-019-01076-x

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Optical coherence tomography angiography analysis of macular vessel density before and after anti-VEGF therapy in eyes with diabetic retinopathy

Abstract

Purpose

Methods

Results

Conclusions

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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