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22.07.2020 | Original Article

Optical coherence tomography angiography findings in Huntington’s disease

verfasst von: Laura Giovanna Di Maio, Daniela Montorio, Silvio Peluso, Pasquale Dolce, Elena Salvatore, Giuseppe De Michele, Gilda Cennamo

Erschienen in: Neurological Sciences | Ausgabe 3/2021

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Abstract

Objectives

To evaluate the retinal and choriocapillaris vascular networks in macular region and the central choroidal thickness (CCT) in patients affected by Huntington disease (HD), using optical coherence tomography angiography (OCTA) and enhanced depth imaging spectral-domain OCT (EDI SD-OCT).

Methods

We assessed the vessel density (VD) in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using OCTA, while CCT was measured by EDI SD-OCT.

Results

Sixteen HD patients (32 eyes) and thirteen healthy controls (26 eyes) were enrolled in this prospective study. No significant difference in retinal and choriocapillaris VD was found between HD patients and controls while CCT turned to be thinner in patients respect to controls. There were no significant relationships between OCTA findings and neurological parameters.

Conclusion

The changes in choroidal structure provide useful information regarding the possible neurovascular involvement in the physiopathology of HD. Choroidal vascular network could be a useful parameter to evaluate the vascular impairment that occurs in this neurodegenerative disease.

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Titel: Optical coherence tomography angiography findings in Huntington’s disease
verfasst von: Laura Giovanna Di Maio
Daniela Montorio
Silvio Peluso
Pasquale Dolce
Elena Salvatore
Giuseppe De Michele
Gilda Cennamo
Publikationsdatum: 22.07.2020
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 3/2021
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04611-2

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Optical coherence tomography angiography findings in Huntington’s disease

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Conclusion

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