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Graefe's Archive for Clinical and Experimental Ophthalmology

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26.10.2019 | Retinal Disorders

Optical coherence tomography (OCT) features of cystoid spaces in choroideremia (CHM)

verfasst von: Vittoria Murro, Dario Pasquale Mucciolo, Dario Giorgio, Andrea Sodi, Ilaria Passerini, Giacomo Bacci, Sara Bargiacchi, Gianni Virgili, Stanislao Rizzo

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 12/2019

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Abstract

Purpose

To investigate the prevalence and features of cystoid spaces (CS) in patients with confirmed genetic diagnosis of choroideremia (CHM) using swept source optical coherence tomography (OCT).

Methods

We retrospectively reviewed CHM patients examined at the Regional Reference Center for Hereditary Retinal Degenerations at the Eye Clinic in Florence. We took into consideration genetically confirmed CHM patients with ophthalmological and swept source optical coherence tomography (OCT) examinations. The presence/absence and location of cystoid spaces in the retina of each eye were reported.

Results

A total of 42 eyes of 21 CHM patients were included in our series. The average age of the patients was 36.5 ± 20.1 (range, 13–73 years). The average best-corrected visual acuity (BCVA) for all patients was 0.63 ± 1.00 logMar (range, 0–2,80). CS were present in 15 eyes of eight patients (8/21, 38%). In all cases, CS were located in inner nuclear layer (INL); in five eyes of three patients, CS were detected also in ganglion cell layer (GCL). CS appeared as microcistoyd abnormalities and were detected in retinal areas characterized by retinal pigment epithelium (RPE) and outer retinal layers atrophy at the transition zone.

Conclusions

Cystoid spaces in choroideremia showed peculiar features; they are clusters of small-size extrafoveal degenerative cysts mainly located in inner nuclear layer at the transition zone where outer retinal layers and RPE are severely damaged.

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Titel: Optical coherence tomography (OCT) features of cystoid spaces in choroideremia (CHM)
verfasst von: Vittoria Murro
Dario Pasquale Mucciolo
Dario Giorgio
Andrea Sodi
Ilaria Passerini
Giacomo Bacci
Sara Bargiacchi
Gianni Virgili
Stanislao Rizzo
Publikationsdatum: 26.10.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 12/2019
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04508-7

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Optical coherence tomography (OCT) features of cystoid spaces in choroideremia (CHM)

Abstract

Purpose

Methods

Results

Conclusions

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Ophthalmika in der Schwangerschaft

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Update Augenheilkunde

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Purpose

Methods

Results

Conclusions

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