Optimal boundary detection method and window settings for coronary atherosclerotic plaque volume analysis in coronary computed tomography angiography: comparison with intravascular ultrasound | springermedizin.de

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European Radiology

Erschienen in:

02.12.2015 | Cardiac

Optimal boundary detection method and window settings for coronary atherosclerotic plaque volume analysis in coronary computed tomography angiography: comparison with intravascular ultrasound

verfasst von: Ran Heo, Hyung-Bok Park, Byoung Kwon Lee, Sanghoon Shin, Reza Arsanjani, James K. Min, Hyuk-Jae Chang

Erschienen in: European Radiology | Ausgabe 9/2016

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Abstract

Objective

To evaluate optimal methodology for quantitative plaque volume analysis by coronary CT angiography (QCT).

Methods

Fifty-one coronary artery segments were evaluated and contour measurements based on two different methods [(1) no gap, or (2) fixed 0.3-mm gap between inner and outer boundary] were compared with intravascular ultrasound (IVUS). In addition, three different window width (WW) and level (WL) settings [fixed (740/220) Hounsfield unit (HU), adjusted (155 % and 65 % of mean luminal intensity of the segment, and aorta adjusted (155 % and 65 % of mean luminal intensity of central aorta)] were used for semiautomated plaque volume analysis.

Results

For boundary detection, the no gap method led to underestimation compared with IVUS (105.4 ± 82.3 vs. 136.1 ± 72.8 mm³, p < 0.001), while fixed 0.3-mm gap showed no difference between IVUS and QCT (136.1 ± 72.8 vs. 139.8 ± 93.9 mm³, p = 0.50). Comparison of the three different window settings demonstrated that the aorta adjusted setting underestimated (120.5 ± 74.3 vs. 136.1 ± 72.8 mm³, p = 0.003), while fixed setting showed the least mean difference compared with IVUS (3.8 ± 39.8 mm³, p = 0.50).

Conclusion

For plaque volumetric assessment, optimal results were obtained with fixed 0.3-mm gap with fixed HU setting (740/220).

Key Points

• Quantitative plaque volume analysis by coronary CT angiography has recently emerged.

• Different boundary detection methods and window width and level settings were evaluated.

• Fixed 0.3-mm gap with fixed HU setting (740/220) afforded optimal results.

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Titel: Optimal boundary detection method and window settings for coronary atherosclerotic plaque volume analysis in coronary computed tomography angiography: comparison with intravascular ultrasound
verfasst von: Ran Heo
Hyung-Bok Park
Byoung Kwon Lee
Sanghoon Shin
Reza Arsanjani
James K. Min
Hyuk-Jae Chang
Publikationsdatum: 02.12.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 9/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-4121-5

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