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European Radiology

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29.10.2015 | Chest

Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in COPD patients

verfasst von: Sang Min Lee, Joon Beom Seo, Sang Min Lee, Namkug Kim, Sang Young Oh, Yeon-Mok Oh

Erschienen in: European Radiology | Ausgabe 7/2016

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Abstract

Objectives

To investigate the optimal threshold of subtraction method for quantification of air trapping on co-registered CT in COPD patients in correlation with pulmonary function parameters.

Methods

From June 2005 to October 2010, 174 patients were included in our study. Inspiration and expiration CT were performed followed by non-rigid registration using in-house software. The subtraction value per voxel between inspiration and registered expiration CT was obtained, and volume fraction of air trapping (air trapping index, ATI), using variable thresholds was calculated. ATI, expiration/inspiration ratio of mean lung density (E/I MLD) and the percentage of lung voxels below −856 HU on expiration CT (Exp₋₈₅₆) were correlated with FEF_25–75% and RV/TLC.

Results

The highest correlation coefficient with FEF_25–75% was −0.656, using the threshold of 80 HU. As for RV/TLC, the highest correlation coefficient was 0.664, using the threshold of 30 HU. When plotting the relationship between subtraction thresholds and FEF_25–75% and RV/TLC, the threshold of 60 HU was most suitable (r = −0.649 and 0.651). Those correlation coefficients were comparable to the results with E/I MLD (r = −0.670 and 0.657) and Exp₋₈₅₆ (r = −0.604 and 0.565).

Conclusions

The optimal threshold for quantification of air trapping was 60 HU and showed comparable correlations with pulmonary function parameters.

Key Points

• The optimal CT threshold of subtraction method for air trapping was 60 HU.

• ATI with 60 HU threshold was comparable to E/I MLD and Exp ₋₈₅₆.

• Emphysema may substantially contribute to air trapping with statistical significance (P < 0.001).

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Titel: Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in COPD patients
verfasst von: Sang Min Lee
Joon Beom Seo
Sang Min Lee
Namkug Kim
Sang Young Oh
Yeon-Mok Oh
Publikationsdatum: 29.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 7/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-4070-z

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Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in COPD patients

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Abstract

Objectives

Methods

Results

Conclusions

Key Points

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