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Erschienen in: InFo Hämatologie + Onkologie 8/2014

03.12.2014 | zertifizierte fortbildung

Diagnostik, Therapie und Nachsorge

Optimale Behandlung des Nasopharynxkarzinoms

verfasst von: Steffi-Johanna Brockmeier, Stephan Ihrler, Prof. Dr. Frank Zimmermann

Erschienen in: InFo Hämatologie + Onkologie | Ausgabe 8/2014

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Zusammenfassung

Das Nasopharynxkarzinom unterscheidet sich in einigen Punkten von anderen Tumoren des Kopf-Hals-Bereichs, z. B. in der Ätiologie. Bei der Behandlung werden Konzepte ohne operatives Vorgehen eingesetzt, wie kombinierte Radiochemotherapien. Besonders wichtig ist eine gründliche Nachsorge, denn auch für ein Rezidiv bestehen noch wirksame Therapieoptionen.
Literatur
1.
Zurück zum Zitat Tsao SW et al. Etiological factors of nasopharyngeal carcinoma. Oral Oncol. 2014;50(5):330–8.PubMedCrossRef Tsao SW et al. Etiological factors of nasopharyngeal carcinoma. Oral Oncol. 2014;50(5):330–8.PubMedCrossRef
2.
Zurück zum Zitat Chan JK et al. Nasopharyngeal carcinoma. In: Barnes L et al. (Hrsg.). Pathology Genetics: Head and Neck Tumours. World Health Organization Classification of Tumours. Lyon: IARC Press; 2005. S. 8597. Chan JK et al. Nasopharyngeal carcinoma. In: Barnes L et al. (Hrsg.). Pathology Genetics: Head and Neck Tumours. World Health Organization Classification of Tumours. Lyon: IARC Press; 2005. S. 8597.
3.
Zurück zum Zitat Lee AW et al. Current management of nasopharyngeal cancer. Semin Radiat Oncol. 2012;22(3):233–44.PubMedCrossRef Lee AW et al. Current management of nasopharyngeal cancer. Semin Radiat Oncol. 2012;22(3):233–44.PubMedCrossRef
4.
Zurück zum Zitat Lee AW et al. Evolution of treatment for nasopharyngeal cancer-success and setback in the intensity-modulated radiotherapy era. Radiother Oncol. 2014;110(3):377–84.PubMedCrossRef Lee AW et al. Evolution of treatment for nasopharyngeal cancer-success and setback in the intensity-modulated radiotherapy era. Radiother Oncol. 2014;110(3):377–84.PubMedCrossRef
5.
Zurück zum Zitat Stasche N, Schmieder A. Kopf-Hals-Karzinome. In: Dornoff W, Hagemann FG, Preiß J, Schmieder A (Hrsg.). Taschenbuch Onkologie 2010: Interdisziplinäre Empfehlungen zur Therapie 2010/2011, Germering: Zuckschwerdt Verlag; 2010. S. 137–44. Stasche N, Schmieder A. Kopf-Hals-Karzinome. In: Dornoff W, Hagemann FG, Preiß J, Schmieder A (Hrsg.). Taschenbuch Onkologie 2010: Interdisziplinäre Empfehlungen zur Therapie 2010/2011, Germering: Zuckschwerdt Verlag; 2010. S. 137–44.
6.
Zurück zum Zitat Ho FC et al. Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer. 2012;12:98.PubMedCentralPubMedCrossRef Ho FC et al. Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence. BMC Cancer. 2012;12:98.PubMedCentralPubMedCrossRef
7.
Zurück zum Zitat National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Head and Neck Cancers. V 2.2014. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Head and Neck Cancers. V 2.2014.
8.
Zurück zum Zitat Ng SH et al. Staging of untreated nasopharyngeal carcinoma with PET/CT: comparison with conventional imaging work-up. Eur J Nucl Med Mol Imaging. 2009;36(1):12–22.PubMedCrossRef Ng SH et al. Staging of untreated nasopharyngeal carcinoma with PET/CT: comparison with conventional imaging work-up. Eur J Nucl Med Mol Imaging. 2009;36(1):12–22.PubMedCrossRef
9.
Zurück zum Zitat Leung SF et al. Plasma Epstein-Barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma. J Clin Oncol. 2006;24(34):5414–8.PubMedCrossRef Leung SF et al. Plasma Epstein-Barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma. J Clin Oncol. 2006;24(34):5414–8.PubMedCrossRef
10.
Zurück zum Zitat Wittekind C. TNM-Klassifikation maligner Tumoren. 7. Aufl. Wiley-Blackwell: Bensheim; 2010. S. 41–56 oder AJCC Cancer Staging Manual. 7. Auflage. New York: Springer; 2010: 41-56. Wittekind C. TNM-Klassifikation maligner Tumoren. 7. Aufl. Wiley-Blackwell: Bensheim; 2010. S. 41–56 oder AJCC Cancer Staging Manual. 7. Auflage. New York: Springer; 2010: 41-56.
11.
Zurück zum Zitat Lee AW et al. The strength/weakness of the AJCC/UICC staging system (7th edition) for nasopharyngeal cancer and suggestions for future improvement. Oral Oncol. 2012;48(10):1007–13.PubMedCrossRef Lee AW et al. The strength/weakness of the AJCC/UICC staging system (7th edition) for nasopharyngeal cancer and suggestions for future improvement. Oral Oncol. 2012;48(10):1007–13.PubMedCrossRef
12.
Zurück zum Zitat Zhang AM et al. Increased treatment-related mortality with additional cisplatin-based chemotherapy in patients with nasopharyngeal carcinoma treated with standard radiotherapy. Radiother Oncol. 2012;104(3):279–85.PubMedCrossRef Zhang AM et al. Increased treatment-related mortality with additional cisplatin-based chemotherapy in patients with nasopharyngeal carcinoma treated with standard radiotherapy. Radiother Oncol. 2012;104(3):279–85.PubMedCrossRef
13.
Zurück zum Zitat Su SF et al. Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone. Int J Radiat Oncol Biol Phys. 2012; 82(1):327–33.PubMedCrossRef Su SF et al. Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone. Int J Radiat Oncol Biol Phys. 2012; 82(1):327–33.PubMedCrossRef
14.
Zurück zum Zitat Caponigro F et al. Treatment approaches to nasopharyngeal carcinoma: a review. Anticancer Drugs. 2010;21(5):471–7.PubMedCrossRef Caponigro F et al. Treatment approaches to nasopharyngeal carcinoma: a review. Anticancer Drugs. 2010;21(5):471–7.PubMedCrossRef
15.
Zurück zum Zitat D’cruz A et al. Consensus recommendations for management of head and neck cancer in Asian countries: a review of international guidelines. Oral Oncol. 2013;49(9):872–7.PubMedCrossRef D’cruz A et al. Consensus recommendations for management of head and neck cancer in Asian countries: a review of international guidelines. Oral Oncol. 2013;49(9):872–7.PubMedCrossRef
16.
Zurück zum Zitat Au E et al. Activity of paclitaxel by three-hour infusion in Asian patients with metastatic undifferentiated nasopharyngeal cancer. Ann Oncol. 1998;9(3):327–9.PubMedCrossRef Au E et al. Activity of paclitaxel by three-hour infusion in Asian patients with metastatic undifferentiated nasopharyngeal cancer. Ann Oncol. 1998;9(3):327–9.PubMedCrossRef
17.
Zurück zum Zitat Chen AM et al. Prospective trial of high-dose reirradiation using daily image guidance with intensity-modulated radiotherapy for recurrent and second primary head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2011;80(3):669–76.PubMedCrossRef Chen AM et al. Prospective trial of high-dose reirradiation using daily image guidance with intensity-modulated radiotherapy for recurrent and second primary head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2011;80(3):669–76.PubMedCrossRef
18.
Zurück zum Zitat Lee AW et al. A randomized trial on addition of concurrentadjuvant chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma. Radiother Oncol. 2011;98(1):15–22.PubMedCrossRef Lee AW et al. A randomized trial on addition of concurrentadjuvant chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma. Radiother Oncol. 2011;98(1):15–22.PubMedCrossRef
19.
Zurück zum Zitat Liang ZG et al. Comparison of concurrent chemoradiotherapy followed by adjuvant chemotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a meta-analysis of 793 patients from 5 randomized controlled trials. Asian Pac J Cancer Prev. 2012;13(11):5747–52.PubMedCrossRef Liang ZG et al. Comparison of concurrent chemoradiotherapy followed by adjuvant chemotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a meta-analysis of 793 patients from 5 randomized controlled trials. Asian Pac J Cancer Prev. 2012;13(11):5747–52.PubMedCrossRef
20.
Zurück zum Zitat Chen X et al. Concurrent chemoradiotherapy comparison of taxanes and platinum versus 5-fluorouracil and platinum in nasopharyngeal carcinoma treatment. Chin Med J (Engl). 2014;127(1):142–9.CrossRef Chen X et al. Concurrent chemoradiotherapy comparison of taxanes and platinum versus 5-fluorouracil and platinum in nasopharyngeal carcinoma treatment. Chin Med J (Engl). 2014;127(1):142–9.CrossRef
21.
Zurück zum Zitat Chen C et al. Triplet combination with paclitaxel, cisplatin and 5-FU is effective in metastatic and/or recurrent nasopharyngeal carcinoma. Cancer Chemother Pharmacol. 2013;71(2):371–8.PubMedCrossRef Chen C et al. Triplet combination with paclitaxel, cisplatin and 5-FU is effective in metastatic and/or recurrent nasopharyngeal carcinoma. Cancer Chemother Pharmacol. 2013;71(2):371–8.PubMedCrossRef
22.
Metadaten
Titel
Diagnostik, Therapie und Nachsorge
Optimale Behandlung des Nasopharynxkarzinoms
verfasst von
Steffi-Johanna Brockmeier
Stephan Ihrler
Prof. Dr. Frank Zimmermann
Publikationsdatum
03.12.2014
Verlag
Urban & Vogel
Erschienen in
InFo Hämatologie + Onkologie / Ausgabe 8/2014
Print ISSN: 2662-1754
Elektronische ISSN: 2662-1762
DOI
https://doi.org/10.1007/s15004-014-0797-y

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