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Erschienen in: Obesity Surgery 5/2019

27.02.2019 | New Concept

Optimization of a Technique to Standardize the Rodent Roux-En-Y Gastric Bypass Model and Troubleshooting of Postoperative Failures

verfasst von: Qingbo Wang, Geng Wang, Chaojie Hu, Jinpeng Du, Jie Bai, Miaomiao Peng, Ning Zhao, Yu Wang, Kaixiong Tao, Guobin Wang, Zefeng Xia

Erschienen in: Obesity Surgery | Ausgabe 5/2019

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Abstract

Background

Rodent models are required in studies on the mechanism of Roux-en-Y gastric bypass (RYGB). However, the construction of the model is hard, and there are various causes of death after surgery in rats.

Methods

RYGB models with procedures containing a series of anatomic landmark were established in rats. Optimized procedures during surgery, possible complications after surgery, and corresponding solutions were studied.

Results

With the introduction of perioperative nursing and optimized surgery procedures, less time-consuming surgeries were performed and higher survival rates were achieved. Trouble-shooting data based on death time points are listed and discussed for various causes of failure.

Conclusions

This study provides practical suggestions for investigators to perform RYGB surgery on rats. The troubleshooting suggestions will help operators to efficiently identify problems in their procedures.
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Metadaten
Titel
Optimization of a Technique to Standardize the Rodent Roux-En-Y Gastric Bypass Model and Troubleshooting of Postoperative Failures
verfasst von
Qingbo Wang
Geng Wang
Chaojie Hu
Jinpeng Du
Jie Bai
Miaomiao Peng
Ning Zhao
Yu Wang
Kaixiong Tao
Guobin Wang
Zefeng Xia
Publikationsdatum
27.02.2019
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 5/2019
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-019-03789-5

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