To identify optimization of dose distributions of target volumes and decrease of radiation doses to normal tissues during stereotactic body radiation therapy (SBRT) for pancreatic cancer with dose-limiting auto-shells.
With the same prescription dose, dose constraints of normal organs and calculation algorithm, treatment plans of each eligible patient were re-generated with 3 shells, 5 shells and 7 shells, respectively. The prescription isodose line and beam number of each patient in 3-shell, 5-shell and 7-shell plan remained the same. Hence, a triplet data set of dosimetric parameters was generated and analyzed.
As the increase of shell number, the conformal index, volumes encompassed by 100% prescription isodose line and 30% prescription isodose line significantly decreased. The new conformal index was higher in 3-shell group than that in 5-shell and 7-shell group. A sharper dose fall-off was found in 5-shell and 7-shell group compared to 3-shell group. And the tumor coverage in 7-shell was better than that of 3-shell and 5-shell. Lower D5cc of the intestine, D10cc of the stomach, Dmax of the spinal cord and smaller V10 of the spleen was confirmed in 7-shell group compared to 3-shell group.
More conformal dose distributions of target volumes and lower radiation doses to normal organs could be performed with the increase of dose-limiting auto-shells, which may be more beneficial to potential critical organs without established dose constraints.
Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand. 1951;102:316–9. PubMed
Colombo F, Benedetti A, Pozza F, Zanardo A, Avanzo RC, Chierego G, et al. Stereotactic radiosurgery utilizing a linear accelerator. Appl Neurophysiol. 1985;48:133–45. PubMed
Chung HT, Kim DG. Modern radiosurgery equipment for treating brain metastases. Prog Neurol Surg. 2012;25:236–47. PubMed
Zhu X, Ju X, Cao F, Fang F, Qing S, Shen Y, et al. Safety and efficacy of stereotactic body radiation therapy combined with S-1 simultaneously followed by sequential S-1 as an initial treatment for locally advanced pancreatic cancer (SILAPANC) trial: study design and rationale of a phase II clinical trial. BMJ Open. 2016;6:e013220. CrossRefPubMedPubMedCentral
Zhu X, Li F, Ju X, Cao F, Cao Y, Fang F, et al. Prognostic role of stereotactic body radiation therapy for elderly patients with advanced and medically inoperable pancreatic cancer. Cancer Med. 2017; http://sci-hub.tw/10.1002/cam4.1164.
Yoon K, Cho B, Kwak J, Lee D, Kwon D, Ahn S, et al. Optimization of Cyberknife treatment planning using a dose-limiting auto-shells method for brain metastases. Med Phys. 2016;43:3371. CrossRef
- Optimization of dose distributions of target volumes and organs at risk during stereotactic body radiation therapy for pancreatic cancer with dose-limiting auto-shells
- BioMed Central
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