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01.12.2014 | Systems-Level Quality Improvement | Ausgabe 12/2014

Journal of Medical Systems 12/2014

Optimization of Noise in Non-integrated Instrumentation Amplifier for the Amplification of Very Low Electrophisiological Signals. Case of Electro Cardio Graphic Signals (ECG).

Journal of Medical Systems > Ausgabe 12/2014
Guy Merlin Ngounou, Martin Kom
Wichtige Hinweise
This article is part of the Topical Collection on Systems-Level Quality Improvement
An erratum to this article can be found at http://​dx.​doi.​org/​10.​1007/​s10916-015-0190-x.


In this paper we present an instrumentation amplifier with discrete elements and optimized noise for the amplification of very low signals. In amplifying signals of very weak amplitude, the noise can completely absorb these signals if the used amplifier does not present the optimal guarantee to minimize the noise. Based on related research and re-viewing of recent patents Journal of Medical Systems, 30:205–209, 2006, we suggest an approach of noise reduction in amplification much more thoroughly than re-viewing of recent patents and we deduce from it the general criteria necessary and essential to achieve this optimization. The comparison of these criteria with the provisions adopted in practice leads to the inadequacy of conventional amplifiers for effective noise reduction. The amplifier we propose is an instrumentation amplifier with active negative feedback and optimized noise for the amplification of signals with very low amplitude. The application of this method in the case of electro cardio graphic signals (ECG) provides simulation results fully in line with forecasts.

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