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Journal of Thrombosis and Thrombolysis

Erschienen in:

22.02.2017

Oral antiplatelet drugs in patients with chronic kidney disease (CKD): a review

verfasst von: Homam Ibrahim, Sunil V. Rao

Erschienen in: Journal of Thrombosis and Thrombolysis | Ausgabe 4/2017

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Abstract

Oral Antiplatelet Drugs (OAD) have a proven track record in the risk reduction of major cardiovascular events in patients with cardiovascular disease and normal kidney function. However, major gaps exist in our understanding of their effects on thrombosis and bleeding in chronic kidney disease (CKD). Clinical practice guidelines are ambiguous about use of such drugs in CKD patients, because patients with moderate to severe CKD were systematically excluded from clinical trials evaluating the efficacy and safety of OAD. Paradoxically, CKD patients are at high risk of thrombosis and major bleeding events. Thus, choosing the right combination of OAD for cardiovascular protection in these patients is challenging. Patients with CKD exhibit high rates of OAD hyporesponsiveness. It is, therefore, imperative to explore the mechanisms responsible for poor response to OAD in CKD patients in order to use these drugs more safely and effectively. This review explores suggested mechanisms of platelet dysfucntion in CKD patients and the available evidence on the efficacy and safety of oral antiplatelet drugs in patients with renal dysfunction.

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Titel: Oral antiplatelet drugs in patients with chronic kidney disease (CKD): a review
verfasst von: Homam Ibrahim
Sunil V. Rao
Publikationsdatum: 22.02.2017
Verlag: Springer US
Erschienen in: Journal of Thrombosis and Thrombolysis / Ausgabe 4/2017
Print ISSN: 0929-5305
Elektronische ISSN: 1573-742X
DOI: https://doi.org/10.1007/s11239-017-1483-3

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