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International Urogynecology Journal

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01.11.2009 | Original Article

Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women

verfasst von: Mary J. G. Zamboni, Carlos A. P. Cabral, Francisco J. B. Sampaio, Luiz E. M. Cardoso

Erschienen in: International Urogynecology Journal | Ausgabe 11/2009

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Abstract

Introduction and hypothesis

Urinary glycosaminoglycans (uGAG) have protective effects against urinary tract disorders. Here we investigated whether oral hormonal contraceptives (OC) affect uGAG excretion.

Methods

Urine specimens were from young women regularly taking: ethinyl estradiol + drospirenone, n = 9; ethinyl estradiol + cyproterone acetate, n = 9; and ethinyl estradiol + gestodene, n = 7. Controls were from ten women not taking OC. Total uGAG was assayed as hexuronic acid/urinary creatinine. Sulfated uGAG species was determined by electrophoresis.

Results

Unlike controls, total uGAG in the two halves of the menstrual cycle was similar in the OC groups. Whole cycle uGAG was higher in the OC groups (p < 0.01), especially for ethinyl estradiol + cyproterone acetate (p < 0.005). The three OC produced decreases of ~50% in heparan sulfate (p < 0.02) and dermatan sulfate (p < 0.02), and a ~100% increase in chondroitin sulfate (p < 0.004).

Conclusions

uGAG excretion is changed in women taking OC, and this might enhance the protective effects of these molecules against urinary tract disorders.

Bishop JR, Schuksz M, Esko JD (2007) Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature 446:1030–1037CrossRefPubMed

Verma RP, Hansch C (2007) Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs. Bioorg Med Chem 15:2223–2268CrossRefPubMed

de Deus JM, Girão MJ, Sartori MG, Baracat EC, Rodrigues de Lima G, Nader HB, Dietrich CP (2003) Glycosaminoglycan profile in bladder and urethra of castrated rats treated with estrogen, progestogen, and raloxifene. Am J Obstet Gynecol 189:1654–1659CrossRefPubMed

Tanaka K, Nakamura T, Takagaki K, Funahashi M, Saito Y, Endo M (1997) Regulation of hyaluronate metabolism by progesterone in cultured fibroblasts from the human uterine cervix. FEBS Lett 402:223–226CrossRefPubMed

Maroclo MV, Pereira SD, Sampaio FJ, Cardoso LE (2005) Urinary glycosaminoglycan excretion during the menstrual cycle in normal young women. J Urol 173:1789–1792CrossRefPubMed

Brollo J, Maroclo M, Sampaio F, Cardoso L (2006) Urinary glycosaminoglycan excretion in postmenopausal women with and without hormone replacement therapy. Eur Urol Suppl 5:40CrossRef

Maroclo M, Cabral C, Pereira S, Sampaio F, Cardoso L (2006) Excretion of urinary glycosaminoglycans during normal pregnancy and puerperium in young women. Eur Urol Suppl 5:41CrossRef

Boevé ER, Cao LC, Verkoelen CF, Romijn JC, de Bruijn WC, Schröder FH (1994) Glycosaminoglycans and other sulphated polysaccharides in calculogenesis of urinary stones. World J Urol 12:43–48CrossRefPubMed

Stabellini G, Calastrini C, Gilli P, Bedani PL (1999) Urinary glycosaminoglycans in recurrent urinary tract infections in kidney transplant patients. Biomed Pharmacother 53:274–277CrossRefPubMed

10.

Wei DC, Politano VA, Selzer MG, Lokeshwar VB (2000) The association of elevated urinary total to sulfated glycosaminoglycan ratio and high molecular mass hyaluronic acid with interstitial cystitis. J Urol 163:1577–1583CrossRefPubMed

11.

Gohel MD, Shum DK, Tam PC (2007) Electrophoretic separation and characterization of urinary glycosaminoglycans and their roles in urolithiasis. Carbohydr Res 342:79–86CrossRefPubMed

12.

Practice Committee of American Society for Reproductive Medicine (2008) Hormonal contraception: recent advances and controversies. Fertil Steril 90(5 Suppl):S103–S113

13.

Cardoso LEM, Mourao PAS (1994) Glycosaminoglycan fractions from human arteries presenting diverse susceptibilities to atherosclerosis have different binding affinities to plasma low density lipoproteins. Arterioscler Thromb 14:115–124PubMed

14.

Tuomikoski P, Aittomaki K, Mikkola TS, Ropponen A, Ylikorkala O (2008) Effect of oral and transdermal hormone therapy on hyaluronic acid in women with and without a history of intrahepatic cholestasis of pregnancy. Am J Obstet Gynecol 198:375.e1–375.e5CrossRef

15.

Batra SC, Iosif CS (1987) Progesterone receptors in the female lower urinary tract. J Urol 138:1301–1304PubMed

16.

Chen EC, Brzyski RG (1999) Exercise and reproductive dysfunction. Fertil Steril 71:1–6CrossRefPubMed

17.

Lee EY, Kim SH, Whang SK, Hwang KY, Yang JO, Hong SY (2003) Isolation, identification, and quantitation of urinary glycosaminoglycans. Am J Nephrol 23:152–157CrossRefPubMed

18.

Barchiesi F, Jackson EK, Gillespie DG, Zacharia LC, Fingerle J, Dubey RK (2002) Methoxyestradiols mediate estradiol-induced antimitogenesis in human aortic SMCs. Hypertension 39:874–879CrossRefPubMed

19.

Xu X, Ding J, Rao G, Shen J, Prinz RA, Rana N, Dmowski WP (2007) Estradiol induces heparanase-1 expression and heparan sulphate proteoglycan degradation in human endometrium. Hum Reprod 22:927–937CrossRefPubMed

20.

Slobodov G, Feloney M, Gran C, Kyker KD, Hurst RE, Culkin DJ (2004) Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis. J Urol 171:1554–1558CrossRefPubMed

21.

Richards JS (2005) Ovulation: new factors that prepare the oocyte for fertilization. Mol Cell Endocrinol 234:75–79CrossRefPubMed

22.

Klipper E, Tatz E, Kisliouk T, Vlodavsky I, Moallem U, Schams D, Lavon Y, Wolfenson D, Meidan R (2009) Induction of heparanase in bovine granulosa cells by luteinizing hormone: possible role during the ovulatory process. Endocrinology 150:413–421CrossRefPubMed

23.

Ji H, Dailey TL, Long V, Chien EK (2008) Androgen-regulated cervical ripening: a structural, biomechanical, and molecular analysis. Am J Obstet Gynecol 198:543.e1–543.e9CrossRef

24.

Ortiz DD (2008) Chronic pelvic pain in women. Am Fam Physician 77:1535–1542PubMed

25.

Harada T, Momoeda M, Taketani Y, Hoshiai H, Terakawa N (2008) Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial. Fertil Steril 90:1583–1588CrossRefPubMed

26.

Hauser PJ, Dozmorov MG, Bane BL, Slobodov G, Culkin DJ, Hurst RE (2008) Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis. J Urol 179:764–769CrossRefPubMed

27.

Parsons CL (2007) The role of the urinary epithelium in the pathogenesis of interstitial cystitis/prostatitis/urethritis. Urology 69(4 Suppl):9–16CrossRefPubMed

28.

Lentz GM, Bavendam T, Stenchever MA, Miller JL, Smalldridge J (2002) Hormonal manipulation in women with chronic, cyclic irritable bladder symptoms and pelvic pain. Am J Obstet Gynecol 186:1268–1271CrossRefPubMed

29.

Finer G, Landau D (2004) Pathogenesis of urinary tract infections with normal female anatomy. Lancet Infect Dis 4:631–635CrossRefPubMed

30.

Pinggera GM, Feuchtner G, Frauscher F, Rehder P, Strasser H, Bartsch G, Herwig R (2005) Effects of local estrogen therapy on recurrent urinary tract infections in young females under oral contraceptives. Eur Urol 47:243–249CrossRefPubMed

Titel: Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women
verfasst von: Mary J. G. Zamboni
Carlos A. P. Cabral
Francisco J. B. Sampaio
Luiz E. M. Cardoso
Publikationsdatum: 01.11.2009
Verlag: Springer-Verlag
Erschienen in: International Urogynecology Journal / Ausgabe 11/2009
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-009-0948-0

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Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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Results

Conclusions

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