The online version of this article (doi:10.1186/1752-1947-8-249) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
FTA, RRG, AFL, ACA, and ENSG designed the study, drafted and revised the manuscript. JBS performed medical examinations and FTA performed oral examinations. ENSG and AFL were responsible for radiological assessment. All authors have read and approved the final manuscript.
Hereditary nonpolyposis colorectal cancer is a colorectal cancer syndrome characterized by the development of colorectal cancer and extracolonic tumors, and this syndrome has an autosomal dominant mode of inheritance. To our knowledge, our study was the first to find dento-osseous anomalies and the second to observe Fordyce granules in a family with individuals with hereditary nonpolyposis colorectal cancer.
Twenty members of one Brazilian family with individuals with hereditary nonpolyposis colorectal cancer were analyzed according to the presence of colorectal cancer and the occurrence of Fordyce granules and dento-osseous anomalies. Their average age was 29.6 (range 7 to 53 years) years. Medical examinations of this family with hereditary nonpolyposis colorectal cancer were performed at the Coloproctology Division of our hospital. Then, all individuals were referred to our Oral Care Center for Inherited Diseases for intraoral examinations to verify the presence of Fordyce granules. Dental panoramic radiographs were done in order to describe dento-osseous anomalies on applying the Dental Panoramic Radiograph System. Of the 20 family members, four were diagnosed with hereditary nonpolyposis colorectal cancer and all four presented Fordyce granules in their upper lip, but only one of these four patients (Case 2) had a significant dento-osseous anomaly.
Our familial study verified the presence of Fordyce granules in all individuals diagnosed with hereditary nonpolyposis colorectal cancer, and the presence of significant dento-osseous anomalies in one of these cases. However, the relationship between oral manifestations and hereditary nonpolyposis colorectal cancer should be further investigated.
Ministry of Health – National Institute of Cancer – INCA. http://www.inca.gov.br/estimativa/2012,
Da Silva FC, De Oliveira LP, Santos EM, Nakagawa WT, Aguiar Junior S, Valentin MD, Rossi BM, de Oliveira Ferreira F: Frequency of extracolonic tumors in Brazilian families with Lynch syndrome: analysis of a hereditary colorectal cancer institutional registry. Fam Cancer. 2010, 9: 563-570. CrossRefPubMed
Jahanbani J, Sandvik L, Lyberg T, Ahlfors E: Evaluation of oral mucosal lesions in 598 referred Iranian patients. Open Dent J. 2009, 27: 42-47. CrossRef
Ferreira RC, Magalhães CS, Moreira AN: Oral mucosal alterations among the institutionalized elderly in Brazil. Braz Oral Res. 2010, 24: 296-302. PubMed
Thakker N, Davies R, Horner K, Armstrong J, Clancy T, Guy S, Harris R, Sloan P, Evans G: The dental phenotype in familial adenomatous polyposis: diagnostic application of a weighted scoring system for changes on dental panoramic radiographs. J Med Genet. 1995, 32: 458-464. CrossRefPubMedPubMedCentral
Agarwall VR, Sloan P, Horner K, Macfarlane TV, Clancy T, Evans G, Thakker N: Dento-osseous changes as diagnostic markers in familial adenomatous polyposis families. Oral Dis. 2003, 9: 29-33. CrossRef
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