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21.05.2018 | Original Article

Oral supplementation of Lanthanum Zirconate nanoparticles moderately affected behavior but drastically disturbed leukocyte count, serum cholesterol levels and antioxidant parameters from vital organs of albino mice in a gender specific manner

verfasst von: Muhammad Nazar Aftab, Irum Naz Akram, Tafheem Khosa, Syeda Qandeel Zahra, Irum Bashir, Muhammad Naeem Ashiq, Furhan Iqbal

Erschienen in: Metabolic Brain Disease | Ausgabe 5/2018

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Abstract

Lanthanum Zirconate nanoparticles (NPs) are used in blades of gas turbine engines to thermally insulate them and to protect them against hot and corrosive gas streams. However, the information regarding their biocompatibility is limited. The present study was aimed to report the effect of Lanthanum Zirconate NPs on selected aspects of behavior, serum biochemistry, complete blood count and antioxidant parameters from vital organs of albino mice in a gender specific manner. Albino mice, seven weeks old, were orally treated with 75 mg/ml solvent/Kg body weight of Lanthanum Zirconate nanoparticles for consecutive 22 days. Saline treated control groups were maintained in parallel. It was observed that rearing frequency was significantly decreased (P = 0.01) in NPs treated male mice. Complete blood count analysis indicated that NPs treated female mice had significantly reduced white blood cells (P = 0.05) and lymphocytes count (P = 0.03). NPs treated male had significantly reduced serum cholesterol levels (P = 0.05) than control group. It was observed that Superoxide dismutase concentrations in liver (P = 0.025) and kidney (P = 0.008), Malondialdehyde concentrations in liver (P = 0.044) of female and Malondialdehyde concentrations in kidney (P < 0.001) and brain (P < 0.001) and catalase concentrations in liver (P = 0.05) of NPs treated male mice were significantly higher than their respective control groups.. In conclusion, we are reporting that oral supplementation with 75 mg/ml solvent/Kg body weight of Lanthanum Zirconate nanoparticles can affect the behavior, leukocyte count, serum cholesterol and antioxidant metabolites from vital organs of albino mice in a gender specific manner.

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Abdelhalim MAK, Moussa SAA (2012) The dimensional hematological alterations induced in blood of rats in vivo by intraperitoneal administration of gold nanoparticles. J Nanomed Nanotechol 3(4):2157–7439CrossRef

Allahyar R, Akbar A, Iqbal F (2015) Creatine monohydrate supplementation for 10 weeks mediates neuroprotection and improves learning/memory following neonatal hypoxia ischemia encephalopathy in female albino mice. Brain Res 1595:92–100CrossRef

Allahyar R, Akbar A, Iqbal F (2017) Effect of creatine monohydrate supplementation on learning, memory and neuromuscular coordination in female albino mice. Acta Neuropsychiat 29(1):27–24CrossRef

Asharani PV, Mun GK, Hande MP, Valiyaveettil S (2009) Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3:279–290CrossRefPubMed

Behbehani GR, Divsalar A, Saboury AA, Faridbod F, Ganjali MR (2010) A thermodynamic study on the binding of human serum albumin with lanthanum ion. Chin J Chem 28(2):159–163CrossRef

Blake DR, Allen RE, Lunec J (1987) Free radicals in biological systems—a review orientated to inflammatory processes. Br Med Bull 43:371–385CrossRefPubMed

Blokhina O, Virolainen E, Fagerstedt KV (2003) Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann Bot 91(2):179–194CrossRefPubMedPubMedCentral

Briner W, Rycek RF, Moellenberndt A, Dannull K (2000) Neurodevelopmental effects of lanthnum in mice. J Neurotoxicol Teratol 22:573–581CrossRef

Cao XQ, Vassen R, Fischer W, Tietz F, Jungen W, Stoever D (2003) Lanthanum–cerium oxide as a thermal barrier-coating material for high-temperature applications. Adv Mater 15(17):1438–1442CrossRef

Cejas P, Casado E, Belda-Iniesta C, De Castro J, Espinosa E, Redondo A, Perona R (2004) Implications of oxidative stress and cell membrane lipid peroxidation in human cancer (Spain). Cancer Causes Control 15(7):707–719CrossRefPubMed

Chidambara MKN, Jayaprakasha GK, Singh RP (2002) Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J Agric Food Chem 50:4791–4479CrossRef

Del Rio D, Stewart AJ, Pellegrini N (2005) A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutrit Met Cardiovas Dis 15(4):316–328CrossRef

Derks NAV, Krugers HJ, Hoogenraad CC, Joëls M, Sarabdjitsingh RS (2017) Effects of early life stress on rodent hippocampal synaptic plasticity: a systematic review. Curr Opin Behav Sci 14:155–166CrossRef

Farid MA, Asghar MA, Ashiq MN, Ehsan MF, Athar M (2014) Hydrothermal synthesis of doped Lanthanum Zirconate nanomaterials and the effect of V-Ge substitution on their structural, electrical and dielectric properties. Mater Res Bull 59:405–410CrossRef

Gaharwar US, Paulraj R (2015) Iron oxide nanoparticles induced oxidative damage in peripheral blood cells of rat. J Biomed Sci Eng 8:274–286CrossRef

Haider S, Naqvi F, Batool Z, Tabassum S, Sadir S, Liaquat L, Perveen T (2015) Pretreatment with curcumin attenuates anxiety while strengthens memory performance after one short stress experience in male rats. Brain Res Bull 115:1–8CrossRefPubMed

Hu R, Gong X, Duan Y, Li N, Che Y, Cui Y, Zhou M, Liu C, Wang H, Hong F (2010) Neurotoxicological effects and the impairement of spatial recognition memory in mice caused by exposure to TiO₂ nanoparticles. J Biomat 31:8043–8050CrossRef

Iqbal S, Ali M, Iqbal F (2015) Long term creatine monohydrate supplementation, following neonatal hypoxic ischemic insult, improves neuromuscular coordination and spatial learning in male albino mouse. Brain Res 1603:76–83CrossRefPubMed

Iqbal F, Hoeger H, Lubec G, Bodamer O (2017) Biochemical and behavioral phenotype of AGAT and GAMT deficient mice following long-term Creatine monohydrate supplementation. Metab Brain Dis 32(6):1951–1961CrossRefPubMed

Jin C, Tang Y, Yang FG, Li XL, Xu S, Fan XY, Huang YY, Yang YJ (2011) Cellular toxicity of TiO2 nanoparticles in anatase and rutile crystal phase. Biol Trace Elem Res 141:3–15CrossRefPubMed

Lateef T, Qureshi SA (2013) Centratherum anthelminticum ameliorates antiatherogenic index in hyperlipidemic rabbit. Int J Pharm 3:698–704

Lever C, Burton S, O keefe J (2006) Rearing on hind legs, environmental novelty, and the hippocampal formation. Rev Neurosci 17(1–2):111–133PubMed

Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Nel A (2003) Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111:455–459CrossRefPubMedPubMedCentral

Liu Z, Kiessling F, Gatjens J (2010) Advanced nanomaterials in multimodal imaging: design, functionalization, and biomedical applications. J Nanomet 2010:1–15. https://doi.org/10.1155/2010/894303 CrossRef

Matés JM, Pérez-Gómez C, De Castro IN (1999) Antioxidant enzymes and human diseases. Clin Biochem 32(8):595–603CrossRefPubMed

Nel A, Xia T, Madler L, Lin N (2006) Toxic potential of materials at the nano level. Science 311:622–627CrossRefPubMed

Oberdorster G, Oberdorster E, Oberdorster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839CrossRefPubMedPubMedCentral

Pasupuleti S, Alapati S, Ganapathy S, Anumolu G, Pully NR, Prakhya BMT (2012) Toxicity of zinc oxide nanoparticles through oral route. Toxicol Ind Health 28(8):675–686CrossRefPubMed

Samson AL, Lining J, Kim A, Zhang H, Shenpeng R, Jessica AA, Sharelle A, Christopher G, Shaun P, Simone M (2015) MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents. Sci Rep 5:16171. https://doi.org/10.1038/srep16171 CrossRefPubMedPubMedCentral

Shohami E, Beit-Yannai E, Horowitz M, Kohen R (1997) Oxidative stress in closed-head injury: brain antioxidant capacity as an indicator of functional outcome. J Cereb Blood Flow Metab 17:1007–1019CrossRefPubMed

Simko M, Mattsson MO (2010) Risks from accidental exposures to engineered nanoparticles and neurological health effects: a critical review. Part Fib Toxicol 7:42CrossRef

Wan R, Mo Y, Feng L, Chien S, Tollerud DJ, Zhang Q (2012) DNA damage caused by metal nanoparticles: involvement of oxidative stress and activation of ATM. Chem Res Toxicol 25:1402–1411CrossRefPubMedPubMedCentral

Wang TC, He X, Zhang ZY, Jia G, Wang X (2006) Effects on serum glucose and lipids in chronic exposure to lanthanum chloride in rat. Zhonghua Yu Fang Yi Xue Za Zhi. Europe PMCorg

Wang H, Wick RL, Xing B (2009) Toxicity of nanoparticulate and bulk ZnO, Al₂O₃ and TiO₂ to the nematode Caenorhabditis elegans. Environ Pollut 157:1171–1177CrossRefPubMed

Weber SB, Lein HL, Grande T, Einarsrud MA (2013) Lanthanum Zirconate thermal barrier coatings deposited by spray pyrolysis. Surf Coat Technol 227:10–14CrossRef

Yongxing W, Xiaorong W, Zichun H (2000) Genotoxicity of lanthanum (III) and gadolinium (III) in human peripheral blood lymphocytes. Bull Environ Contam Toxicol 64(4):611–616CrossRefPubMed

Zahra K, Khan M, Iqbal F (2015) Oral supplementation of Ocimum basilicum has the potential to improves the locomotory, exploratory, anxiolytic behavior and learning in adult male albino mice. Neurol Sci 36:73–78CrossRefPubMed

Zeng H (2008) Synthesis, properties and potential applications of multicomponent magnetic nanoparticles. Ad Funct Mat 18:391–400CrossRef

Zhang J, Guo X, Jung YG, Li L, Knapp J (2016) Lanthanum Zirconate based thermal barrier coatings. Surf Coat Technol. https://doi.org/10.1016/j.surfcoat.2016.10.019 S0257-8972(16)31013-1CrossRef

Titel: Oral supplementation of Lanthanum Zirconate nanoparticles moderately affected behavior but drastically disturbed leukocyte count, serum cholesterol levels and antioxidant parameters from vital organs of albino mice in a gender specific manner
verfasst von: Muhammad Nazar Aftab
Irum Naz Akram
Tafheem Khosa
Syeda Qandeel Zahra
Irum Bashir
Muhammad Naeem Ashiq
Furhan Iqbal
Publikationsdatum: 21.05.2018
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 5/2018
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0248-9

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Oral supplementation of Lanthanum Zirconate nanoparticles moderately affected behavior but drastically disturbed leukocyte count, serum cholesterol levels and antioxidant parameters from vital organs of albino mice in a gender specific manner

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