Skip to main content
Erschienen in: Clinical Oral Investigations 5/2019

02.10.2018 | Original Article

Oral symptoms and oral health-related quality of life in patients with chronic kidney disease from predialysis to posttransplantation

verfasst von: Hellevi Ruokonen, Karita Nylund, Jukka H. Meurman, Anna M. Heikkinen, Jussi Furuholm, Timo Sorsa, Risto Roine, Fernanda Ortiz

Erschienen in: Clinical Oral Investigations | Ausgabe 5/2019

Einloggen, um Zugang zu erhalten

Abstract

Objective

This prospective follow-up cohort study analyzed chronic kidney disease (CKD) patients’ oral symptoms, health habits, and oral health-related quality of life (OHRQoL), from predialysis to posttransplantation. A simplified questionnaire method (Oral Health Quality Score, OHQS), based on these and clinical findings, was constructed and tested for identifying patients in need for referral to a dentist.

Material and methods

Fifty-three CKD patients were followed up for a mean of 10.3 years. Clinical oral, radiological, and salivary examination was performed at baseline and posttransplantation. Total Dental Index (TDI) indicating inflammation was calculated. The patients filled out a questionnaire on symptoms, oral hygiene and health care habits, smoking, alcohol use, and medication. General health-related quality of life was assessed with the 15-dimensional (15D) instrument at posttransplantation. Descriptive and analytical methods were used in statistics.

Results

OHQS significantly correlated with high TDI (p = 0.017), number of teeth (p = 0.031), and unstimulated salivary flow rate (p = 0.001) in transplanted patients. Number of daily medications showed a negative correlation with the OHQS (r = − 0.30; p = 0.028). The prevalence of oral symptoms was slightly, but not significantly, more common posttransplantation compared with predialysis stage.

Conclusion

OHQS identified patients with high oral inflammatory score thus confirming our study hypothesis.

Clinical relevance

Use of OHQS and measuring salivary flow indicate patients at risk for oral diseases. These markers might be easy to use chair-side also by auxiliary personnel.
Literatur
1.
Zurück zum Zitat Eckardt KU, Coresh J, Devuyst O, Johnson RJ, Köttgen A, Levey AS, Levin A (2013) Evolving importance of kidney disease: from subspecialty to global health burden. Lancet 382:158–169CrossRefPubMed Eckardt KU, Coresh J, Devuyst O, Johnson RJ, Köttgen A, Levey AS, Levin A (2013) Evolving importance of kidney disease: from subspecialty to global health burden. Lancet 382:158–169CrossRefPubMed
2.
Zurück zum Zitat Cignarelli M, Lamacchia O (2007) Obesity and kidney disease. Nutr Metab Cardiovasc Dis 17:757–762CrossRefPubMed Cignarelli M, Lamacchia O (2007) Obesity and kidney disease. Nutr Metab Cardiovasc Dis 17:757–762CrossRefPubMed
3.
Zurück zum Zitat Fisher MA, Taylor GW, Shelton BJ, Jamerson KA, Rahman M, Ojo AO, Sehgal AR (2008) Periodontal disease and other nontraditional risk factors for CKD. Am J Kidney Dis 51:45–52CrossRefPubMed Fisher MA, Taylor GW, Shelton BJ, Jamerson KA, Rahman M, Ojo AO, Sehgal AR (2008) Periodontal disease and other nontraditional risk factors for CKD. Am J Kidney Dis 51:45–52CrossRefPubMed
4.
Zurück zum Zitat Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AYM, Yang CW (2013) Chronic kidney disease: global dimension and perspectives. Lancet 382:260–272CrossRefPubMed Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AYM, Yang CW (2013) Chronic kidney disease: global dimension and perspectives. Lancet 382:260–272CrossRefPubMed
5.
Zurück zum Zitat Vesterinen M, Ruokonen H, Furuholm J, Honkanen E, Meurman JH (2012) Clinical questionnaire study of oral health care and symptoms in diabetic vs. non-diabetic predialysis chronic kidney disease patients. Clin Oral Investig 16:559–563CrossRefPubMed Vesterinen M, Ruokonen H, Furuholm J, Honkanen E, Meurman JH (2012) Clinical questionnaire study of oral health care and symptoms in diabetic vs. non-diabetic predialysis chronic kidney disease patients. Clin Oral Investig 16:559–563CrossRefPubMed
6.
Zurück zum Zitat Nylund KM, Meurman JH, Heikkinen AM, Furuholm JO, Ortiz F, Ruokonen HM (2018) Oral health in patients with renal disease: a longitudinal study from predialysis to kidney transplantation. Clin Oral Investig 22(1):339–347CrossRefPubMed Nylund KM, Meurman JH, Heikkinen AM, Furuholm JO, Ortiz F, Ruokonen HM (2018) Oral health in patients with renal disease: a longitudinal study from predialysis to kidney transplantation. Clin Oral Investig 22(1):339–347CrossRefPubMed
7.
Zurück zum Zitat Nylund K, Meurman JH, Heikkinen AM, Honkanen E, Vesterinen M, Ruokonen H (2015) Oral health in predialysis patients with emphasis on periodontal disease. Quintessence Int 46:899–907PubMed Nylund K, Meurman JH, Heikkinen AM, Honkanen E, Vesterinen M, Ruokonen H (2015) Oral health in predialysis patients with emphasis on periodontal disease. Quintessence Int 46:899–907PubMed
8.
Zurück zum Zitat Vesterinen M, Ruokonen H, Leivo T, Honkanen AM, Honkanen E, Kari K, Lindqvist C, Meurman JH (2007) Oral health and dental treatment of patients with renal disease. Quintessence Int 38:211–219PubMed Vesterinen M, Ruokonen H, Leivo T, Honkanen AM, Honkanen E, Kari K, Lindqvist C, Meurman JH (2007) Oral health and dental treatment of patients with renal disease. Quintessence Int 38:211–219PubMed
9.
Zurück zum Zitat Locker D, Allen F. (2007) What do measures of oral health and dental treatment of patients with renal disease Oral Epidemiol 35: 401–411 Locker D, Allen F. (2007) What do measures of oral health and dental treatment of patients with renal disease Oral Epidemiol 35: 401–411
10.
Zurück zum Zitat Patel RR, Richards PS, Inglehart MR (2008) Periodontal health, quality of life, and smiling patterns – an exploration. J Periodontol 79:224–231CrossRefPubMed Patel RR, Richards PS, Inglehart MR (2008) Periodontal health, quality of life, and smiling patterns – an exploration. J Periodontol 79:224–231CrossRefPubMed
11.
Zurück zum Zitat Abrahamsson KH, Wennström JL, Hallberg U (2008) Patients’ views on periodontal disease; attitudes to oral health and expectancy of periodontal treatment: a qualitative interview study. Oral Health Prev Dent 6:209–216PubMed Abrahamsson KH, Wennström JL, Hallberg U (2008) Patients’ views on periodontal disease; attitudes to oral health and expectancy of periodontal treatment: a qualitative interview study. Oral Health Prev Dent 6:209–216PubMed
13.
Zurück zum Zitat Broder HL, Wilson-Genderson M (2007) Reliability and convergent and discriminant validity of the child oral health impact profile (COHIP child’s version). Community Dent Oral Epidemiol 35(Suppl 1):20–31CrossRefPubMed Broder HL, Wilson-Genderson M (2007) Reliability and convergent and discriminant validity of the child oral health impact profile (COHIP child’s version). Community Dent Oral Epidemiol 35(Suppl 1):20–31CrossRefPubMed
14.
Zurück zum Zitat Slade GD (2002) Assessment of oral health-related quality of life. In: Inglehart MR, Bagramian RA (eds) Oral health-related quality of life, Quintessence Publishing Co, pp 29–46 Slade GD (2002) Assessment of oral health-related quality of life. In: Inglehart MR, Bagramian RA (eds) Oral health-related quality of life, Quintessence Publishing Co, pp 29–46
15.
Zurück zum Zitat McGrath C, Bedi R (2001) An evaluation of a new measure of oral health related quality of life – OHQoL-UK (W)©. Community Dent Health 18:138–143PubMed McGrath C, Bedi R (2001) An evaluation of a new measure of oral health related quality of life – OHQoL-UK (W)©. Community Dent Health 18:138–143PubMed
16.
Zurück zum Zitat Slade G (1997) Derivation and validation of a short form oral health impact profile. Community Dent Health 25:284–290 Slade G (1997) Derivation and validation of a short form oral health impact profile. Community Dent Health 25:284–290
17.
18.
Zurück zum Zitat Klein HT, Palmer CE, Knuston JW (1938) Studies on dental caries I dental status and dental needs of alimentary school children. Public Health Rep 53:751–765CrossRef Klein HT, Palmer CE, Knuston JW (1938) Studies on dental caries I dental status and dental needs of alimentary school children. Public Health Rep 53:751–765CrossRef
19.
Zurück zum Zitat World Health Organization Geneva (1997) Oral health survey basic methods. 4th ed. Delhi; AITBS publishers and distributors, pp 36–38 World Health Organization Geneva (1997) Oral health survey basic methods. 4th ed. Delhi; AITBS publishers and distributors, pp 36–38
20.
Zurück zum Zitat Mattila KJ, Nieminen MS, Valtonen VV, Rasi VP, Kesaniemi YA, Syrjala SL, Jungell PS, Isoluoma M, Hietaniemi K, Jokinen MJ (1989) Association between dental health and acute myocardial infarction. BMJ 298:779–781CrossRefPubMedPubMedCentral Mattila KJ, Nieminen MS, Valtonen VV, Rasi VP, Kesaniemi YA, Syrjala SL, Jungell PS, Isoluoma M, Hietaniemi K, Jokinen MJ (1989) Association between dental health and acute myocardial infarction. BMJ 298:779–781CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Lindy O, Suomalainen K, Makela M, Lindy S (2008) Statin use is associated with fewer periodontal lesions: a retrospective study. BMC Oral Health 8:16–6831-8-16CrossRef Lindy O, Suomalainen K, Makela M, Lindy S (2008) Statin use is associated with fewer periodontal lesions: a retrospective study. BMC Oral Health 8:16–6831-8-16CrossRef
22.
Zurück zum Zitat Sintonen H (2001) The 15D instrument of health-related quality of life: properties and applications. Ann Med 33:328–336CrossRef Sintonen H (2001) The 15D instrument of health-related quality of life: properties and applications. Ann Med 33:328–336CrossRef
23.
Zurück zum Zitat Ortiz F, Aronen P, Koskinen P et al (2014) Health-related quality of life after kidney transplantation: who benefits the most? Transpl Int 27:1143–1151CrossRefPubMed Ortiz F, Aronen P, Koskinen P et al (2014) Health-related quality of life after kidney transplantation: who benefits the most? Transpl Int 27:1143–1151CrossRefPubMed
24.
Zurück zum Zitat Niklander S, Veas L, Barrera C, Fuentes F, Chiappini G, Marshall M (2017) Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life. Braz Oral Res 16:31. https://doi.org/10.1590/1807-3107BOR-2017.vol31.0014 Niklander S, Veas L, Barrera C, Fuentes F, Chiappini G, Marshall M (2017) Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life. Braz Oral Res 16:31. https://​doi.​org/​10.​1590/​1807-3107BOR-2017.​vol31.​0014
25.
Zurück zum Zitat Närhi TO, Meurman JH, Ainamo A (1999) Xerostomia and hyposalivation Causes, consequences and treatment in the elderly. Drugs Aging 15:103–116CrossRefPubMed Närhi TO, Meurman JH, Ainamo A (1999) Xerostomia and hyposalivation Causes, consequences and treatment in the elderly. Drugs Aging 15:103–116CrossRefPubMed
26.
Zurück zum Zitat Närhi TO, Meurman JH, Ainamo A (1992) Association between salivary flow rate and the use of systemic medication among 76-, 81-, and 86- year – old inhabitants in Helsinki, Finland. J Dent Res 1:1875–1880CrossRef Närhi TO, Meurman JH, Ainamo A (1992) Association between salivary flow rate and the use of systemic medication among 76-, 81-, and 86- year – old inhabitants in Helsinki, Finland. J Dent Res 1:1875–1880CrossRef
27.
Zurück zum Zitat Liem YS, Bosch JL, Arends LR, Heijenbrok-Kal MH, Hunink MG (2007) Quality of life assessed with the medical outcomes study short form 36-item health survey of patients on renal replacement therapy: a systematic review and meta-analysis. Value Health 10:390–397CrossRefPubMed Liem YS, Bosch JL, Arends LR, Heijenbrok-Kal MH, Hunink MG (2007) Quality of life assessed with the medical outcomes study short form 36-item health survey of patients on renal replacement therapy: a systematic review and meta-analysis. Value Health 10:390–397CrossRefPubMed
28.
Zurück zum Zitat Jofre R, Lopez-Gomez JM, Moreno F, Sanz-Guajardo D, Valderrabano F (1998) Changes in quality of life after renal transplantation. Am J Kidney Dis 32:93–100CrossRefPubMed Jofre R, Lopez-Gomez JM, Moreno F, Sanz-Guajardo D, Valderrabano F (1998) Changes in quality of life after renal transplantation. Am J Kidney Dis 32:93–100CrossRefPubMed
Metadaten
Titel
Oral symptoms and oral health-related quality of life in patients with chronic kidney disease from predialysis to posttransplantation
verfasst von
Hellevi Ruokonen
Karita Nylund
Jukka H. Meurman
Anna M. Heikkinen
Jussi Furuholm
Timo Sorsa
Risto Roine
Fernanda Ortiz
Publikationsdatum
02.10.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Oral Investigations / Ausgabe 5/2019
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-018-2647-z

Weitere Artikel der Ausgabe 5/2019

Clinical Oral Investigations 5/2019 Zur Ausgabe

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.