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22.05.2024 | Leitthema

Organoids—the key to novel therapies for the inner ear?

verfasst von: Priv.-Doz. Dr. med. Dr. med. habil. Marc Diensthuber, Timo Stöver

Erschienen in: HNO | Sonderheft 2/2024

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Abstract

The sensitivity and the complexity of the human inner ear in conjunction with the lack of regenerative capacity are the main reasons for hearing loss and tinnitus. Progress in the development of protective and regenerative therapies for the inner ear often failed in the past not least due to the fact that no suitable model systems for cell biological and pharmacological in vitro studies were available. A novel technology for creating “mini-organs”, so-called organoids, could solve this problem and has now also reached inner ear research. It makes it possible to produce inner ear organoids from cochlear stem/progenitor cells, embryonic and induced pluripotent stem cells that mimic the structural characteristics and functional properties of the natural inner ear. This review focuses on the biological basis of these inner ear organoids, the current state of research and the promising prospects that are now opening up for basic and translational inner ear research.

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Titel: Organoids—the key to novel therapies for the inner ear?
verfasst von: Priv.-Doz. Dr. med. Dr. med. habil. Marc Diensthuber
Timo Stöver
Publikationsdatum: 22.05.2024
Verlag: Springer Medizin
Erschienen in: HNO / Ausgabe Sonderheft 2/2024
Print ISSN: 0017-6192
Elektronische ISSN: 1433-0458
DOI: https://doi.org/10.1007/s00106-023-01367-x

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