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Erschienen in: Pediatric Cardiology 1/2020

08.10.2019 | Original Article

Orthostatic and Exercise Effects in Children Years After Kawasaki Disease

verfasst von: Yoshihiro Nakamura, Takehiro Hama, Yoshie Nakamura, Hideki Tsukada, Yoichiro Oda, Shoichi Awa

Erschienen in: Pediatric Cardiology | Ausgabe 1/2020

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Abstract

The long-term orthostatic and/or exercise hemodynamic effects in children years after Kawasaki disease (KD) were studied using clinical data from the treadmill exercise test (TMET). Heart rate (HR) and blood pressures (BPs) recorded in TMET were compared between two age, gender, and body scale-matched groups of patients with and without a history of KD. The KD group included 60 patients (9.8 ± 2.7 years old) 6.6 ± 2.6 years after KD without coronary arterial aneurysm. The non-KD group included 60 children (10.2 ± 2.7 years old) with other diagnoses. The exercise tolerance in TMET was not statistically different between the two groups. The KD group had a faster HR on standing than the non-KD group by 8.6% (101.5 ± 12.2 vs. 93.5 ± 15.9 bpm, respectively; P < 0.01), suggesting weaker and/or retarded orthostatic vasoconstriction. The pulse pressure was largely augmented above the 4th stage beyond 160 mmHg in 10.6 versus 0% (5 vs. 0) of the KD and non-KD groups (P < 0.05), respectively, while HR and BPs were not significantly different through exercise stages between the two groups. The KD group also showed a faster HR recovery five minutes after exercise than the non-KD group, by 5.7% (108.0 ± 11.6 vs. 102.2 ± 14.2 bpm, respectively; P < 0.05). Our results might indicate long-term subclinical impacts on the vascular tonus of children years after the disease that have not been recognized in previous studies.
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Metadaten
Titel
Orthostatic and Exercise Effects in Children Years After Kawasaki Disease
verfasst von
Yoshihiro Nakamura
Takehiro Hama
Yoshie Nakamura
Hideki Tsukada
Yoichiro Oda
Shoichi Awa
Publikationsdatum
08.10.2019
Verlag
Springer US
Erschienen in
Pediatric Cardiology / Ausgabe 1/2020
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-019-02216-x

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