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Current Osteoporosis Reports

Erschienen in:

26.11.2021 | Osteocytes (J Delgado-Calle and J Klein-Nulend, Section Editors)

Osteocytes and Estrogen Deficiency

verfasst von: Laoise M. McNamara

Erschienen in: Current Osteoporosis Reports | Ausgabe 6/2021

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Abstract

Purpose of Review

Postmenopausal osteoporosis reduces circulating estrogen levels, which leads to osteoclast resorption, bone loss, and fracture. This review addresses emerging evidence that osteoporosis is not simply a disease of bone loss but that mechanosensitive osteocytes that regulate both osteoclasts and osteoblasts are also impacted by estrogen deficiency.

Recent Findings

At the onset of estrogen deficiency, the osteocyte mechanical environment is altered, which coincides with temporal changes in bone tissue composition. The osteocyte microenvironment is also altered, apoptosis is more prevalent, and hypermineralization occurs. The mechanobiological responses of osteocytes are impaired under estrogen deficiency, which exacerbates osteocyte paracrine regulation of osteoclasts.

Summary

Recent research reveals changes in osteocytes during estrogen deficiency that may play a critical role in the etiology of the disease. A paradigm change for osteoporosis therapy requires an advanced understanding of such changes to establish the efficacy of osteocyte-targeted therapies to inhibit resorption and secondary mineralization.

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Titel: Osteocytes and Estrogen Deficiency
verfasst von: Laoise M. McNamara
Publikationsdatum: 26.11.2021
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 6/2021
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-021-00702-x

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Springer Medizin

Osteocytes and Estrogen Deficiency

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Purpose of Review

Recent Findings

Summary

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