Background
Methods
Patients
Immunohistochemistry
Statistics
Results
Patient characteristics
n | % | ||
---|---|---|---|
T | 0 | 1 | 0.8 |
1 | 59 | 49.6 | |
2 | 33 | 27.7 | |
3 | 6 | 5.0 | |
undefined | 20 | 16.8 | |
N | 0 | 58 | 48.7 |
1 | 14 | 11.8 | |
2 | 16 | 13.4 | |
3 | 11 | 9.2 | |
undefined | 20 | 16.8 | |
grade | 1 | 36 | 30.3 |
2 | 65 | 54.6 | |
3 | 18 | 15.1 | |
Her2 | low | 69 | 58.0 |
high | 29 | 24.4 | |
undefined | 21 | 17.6 | |
PR | - | 64 | 53.8 |
+ | 54 | 45.4 | |
undefined | 1 | 0.8 | |
ER | - | 59 | 49.6 |
+ | 59 | 49.6 | |
undefined | 1 | 0.8 | |
BRCA-1 | wild type | 52 | 43.7 |
mutant | 26 | 21.8 | |
undefined | 41 | 34.5 | |
familial | no | 44 | 37.0 |
yes | 40 | 33.6 | |
undefined | 35 | 29.4 | |
chemotherapy | AC 4 courses every 21 days, CMF 6 courses every 28 days | 34 | 28.6 |
CMF 6 courses every 28 days | 55 | 46.2 | |
no | 30 | 25.2 | |
radiation therapy | chest (50 Gy; Mon-Fri 2 Gy) | 41 | 34.5 |
chest/axilla (50 Gy; Mon-Fri 2 Gy) | 31 | 26.1 | |
no | 47 | 39.5 | |
hormone treatment | no | 54 | 45.4 |
tamoxifen | 62 | 52.1 |
Immunohistochemistry
Exon 4 cyt.per. | Exon 4 cyt.int. | OPNc nucl.per. | OPNc nucl.int. | Tumor grade | ||
---|---|---|---|---|---|---|
exon 4 | Pearson Correlation | 1 |
0.69115
|
0.41194
|
0.53769
| 0.10199 |
cyt.per. |
p-value |
<0.0001
|
<0.0001
|
<0.0001
| 0.2697 | |
exon 4 | Pearson Correlation | 1 | 0.31522 |
0.50491
| 0.21883 | |
cyt.int. |
p-value |
0.0005
|
<0.0001
|
0.0168
| ||
OPNc | Pearson Correlation | 1 |
0.6636
| 0.0679 | ||
nucl.per. |
p-value |
<0.0001
| 0.4631 | |||
OPNc | Pearson Correlation | 1 | 0.08674 | |||
nucl.int. |
p-value | 0.3483 | ||||
tumor grade | Pearson Correlation | 1 |
Parametric (lognormal) | Logrank | Wilcoxon | ||||
---|---|---|---|---|---|---|
χ2
|
p-value | χ2
|
p-value | χ2
|
p-value | |
exon 4 intensity | 4.82 |
0.0281
| 9.8692 |
0.0197
| 16.3818 |
0.0009
|
exon 4 high/low | 7.9144 |
0.0049
| 15.5494 |
<0.0001
| ||
OPNc intensity | 7.24 |
<0.0001
| 16.9014 |
0.0007
| 27.5348 |
<0.0001
|
OPNc high/low | 2.1234 | 0.1438 | 6.4847 |
0.0109
| ||
tumor grade | 7.63 |
0.0057
| 11.392 |
0.0098
| 9.5087 |
0.0232
|
Cancer treatment
Years of survival | |||
---|---|---|---|
Treatment | Mean | std | n |
hormone no (all subgroups) | 6.48 | 3.96 | 54 |
hormone yes (all subgroups) | 7.44 | 4.35 | 64 |
hormone alone | 9.89 | 2.00 | 18 |
hormone and chemo | 6.63 | 4.38 | 16 |
hormone and radiation | 5.10 | 4.63 | 10 |
hormone, chemo, radiation | 7.10 | 4.84 | 21 |
chemo no (all subgroups) | 8.30 | 3.79 | 30 |
chemo yes (all subgroups) | 6.57 | 4.22 | 89 |
chemo alone | 7.92 | 4.57 | 13 |
chemo and hormone | 6.63 | 4.38 | 16 |
chemo and radiation | 5.82 | 3.66 | 39 |
chemo, hormone, radiation | 7.10 | 4.84 | 21 |
chemo (CMF 6 courses every 28 days) | 6.27 | 4.36 | 55 |
chemo (AC 4 courses every 21 days, CMF 6 courses every 28 days) | 7.06 | 4.00 | 34 |
radiation no (all subgroups) | 8.23 | 3.90 | 47 |
radiation yes (all subgroups) | 6.21 | 4.17 | 72 |
radiotherapy alone | 10.00 | 1.41 | 2 |
radiation and hormone | 5.10 | 4.63 | 10 |
radiation and chemo | 5.82 | 3.66 | 39 |
radiation, chemo, hormone | 7.10 | 4.84 | 21 |
Osteopontin variants and specific treatment regimens
Osteopontin variants as predictive markers
Exon 4 intensity | Exon 4 % | OPN-c intensity | OPN-c % | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Treatment | n | Odds ratio | 95 % CI |
p-value | Supre-mum test | Odds ratio | 95 % CI |
p-value | Supre-mum test | Odds ratio | 95 % CI |
p-value | Supre-mum test | Odds ratio | 95 % CI |
p-value | Supre-mum test |
hormone no (all subgroups) | 54 | 0.503 |
0.287-0.881
|
0.016
| 0.104 | 1.087 | 0.624-1.895 | 0.767 | 0.908 | 0.620 | 0.353-1.089 | 0.096 | 0.178 | 1.210 | 0.696-2.102 | 0.500 | 0.954 |
hormone yes (all subgroups) | 65 | 0.657 | 0.381-1.134 | 0.131 |
<.0001
| 0.687 | 0.391-1.206 | 0.191 | 0.056 | 0.826 | 0.463-1.473 | 0.517 |
0.005
| 1.101 | 0.630-1.923 | 0.735 | 0.704 |
hormone alone | 18 | 1.534 | 0.430-5.467 | 0.509 | 0.614 | 1.122 | 0.420-2.998 | 0.819 | 0.616 | 1.661 | 0.607-4.542 | 0.323 | 0.518 | 1.113 | 0.383-3.235 | 0.845 | 0.607 |
hormone and chemo | 16 | 0.412 | 0.129-1.316 | 0.134 |
0.022
| 0.637 | 0.173-2.343 | 0.497 | 0.064 | 0.634 | 0.204-1.973 | 0.432 |
0.049
| 1.352 | 0.441-4.148 | 0.598 | 0.269 |
hormone and radiation | 10 | 0.358 | 0.069-1.862 | 0.222 | 0.180 | 0.495 | 0.096-2.558 | 0.401 | 0.568 | 0.250 | 0.029-2.180 | 0.209 | 0.185 | 0.827 | 0.192-3.561 | 0.798 | 0.597 |
hormone, chemo, radiation | 21 | 0.598 | 0.169-2.112 | 0.424 | 0.763 | 0.604 | 0.218-1.676 | 0.333 | 0.801 | 0.867 | 0.278-2.710 | 0.806 | 0.375 | 0.894 | 0.310-2.580 | 0.836 | 0.810 |
chemo no (all subgroups) | 30 | 0.711 | 0.320-1.580 | 0.403 |
0.025
| 0.794 | 0.366-1.722 | 0.560 | 0.233 | 0.903 | 0.391-2.084 | 0.811 | 0.134 | 0.978 | 0.425-2.254 | 0.959 | 0.612 |
chemo yes (all subgroups) | 89 | 0.582 |
0.371-0.913
|
0.019
|
0.001
| 0.873 | 0.552-1.383 | 0.564 | 0.520 | 0.694 | 0.439-1.098 | 0.119 |
0.003
| 1.181 | 0.754-1.848 | 0.468 | 0.327 |
chemo (CMF) | 55 | 0.524 |
0.290- 0.943
|
0.031
|
0.008
| 0.727 | 0.403-1.314 | 0.291 | 0.693 | 0.706 | 0.391-1.276 | 0.249 |
0.013
| 1.113 | 0.626-1.979 | 0.715 | 0.337 |
chemo (AC/CMF) | 34 | 0.688 | 0.338-1.400 | 0.302 | 0.144 | 1.252 | 0.596-2.632 | 0.553 | 0.543 | 0.681 | 0.329-1.410 | 0.301 | 0.121 | 1.280 | 0.608-2.694 | 0.515 | 0.727 |
chemo alone | 13 | 0.418 | 0.111-1.574 | 0.197 | 0.763 | 1.207 | 0.367-3.971 | 0.757 | 0.637 | 0.711 | 0.205-2.468 | 0.592 |
0.047
| 1.200 | 0.362-3.980 | 0.766 | 0.560 |
chemo and radiation | 39 | 0.546 | 0.285-1.047 | 0.069 |
0.027
| 1.343 | 0.686-2.629 | 0.389 | 0.449 | 0.623 | 0.320-1.213 | 0.164 | 0.444 | 1.215 | 0.641-2.304 | 0.551 | 0.950 |
radiation no (all subgroups) | 47 | 0.647 | 0.333-1.259 | 0.200 |
0.024
| 0.973 | 0.519-1.824 | 0.933 | 0.203 | 0.981 | 0.527-1.826 | 0.951 | 0.105 | 1.400 | 0.746-2.627 | 0.294 | 0.404 |
radiation yes (all subgroups) | 72 | 0.626 | 0.376-1.044 | 0.073 |
0.002
| 0.774 | 0.466-1.285 | 0.321 | 0.489 | 0.675 | 0.394-1.157 | 0.153 |
0.036
| 1.086 | 0.659-1.791 | 0.745 | 0.832 |
Exon 4 intensity | Exon 4 % | OPN-c intensity | OPN-c % | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Logrank | Wilcoxon | Logrank | Wilcoxon | Logrank | Wilcoxon | Logrank | Wilcoxon | ||||||||||
Treatment | n | χ2
|
p-value | χ2
|
p-value | χ2
|
p-value | χ2
|
p-value | χ2
|
p-value | χ2
|
p-value | χ2
|
p-value | χ2
|
p-value |
hormone no (all subgroups) | 54 | 7.127 |
0.008
| 9.087 |
0.003
| 0.106 | 0.745 | 0.015 | 0.902 | 3.384 | 0.066 | 5.373 |
0.021
| 0.551 | 0.458 | 0.372 | 0.542 |
hormone yes (all subgroups) | 65 | 2.631 | 0.105 | 6.981 |
0.008
| 1.970 | 0.160 | 3.267 | 0.071 | 0.480 | 0.489 | 2.218 | 0.136 | 0.130 | 0.719 | 0.140 | 0.708 |
hormone alone | 18 | 0.591 | 0.442 | 0.226 | 0.635 | 0.069 | 0.793 | 0.071 | 0.790 | 1.303 | 0.254 | 0.961 | 0.327 | 0.050 | 0.823 | 0.184 | 0.668 |
hormone and chemo | 16 | 2.613 | 0.106 | 3.937 |
0.047
| 0.531 | 0.466 | 1.071 | 0.301 | 0.707 | 0.401 | 1.778 | 0.182 | 0.317 | 0.573 | 0.101 | 0.751 |
hormone and radiation | 10 | 1.833 | 0.176 | 2.709 | 0.100 | 0.837 | 0.360 | 0.987 | 0.320 | 2.049 | 0.152 | 2.485 | 0.115 | 0.075 | 0.784 | 0.011 | 0.915 |
hormone, chemo, radiation | 21 | 0.703 | 0.402 | 0.601 | 0.438 | 1.036 | 0.309 | 1.139 | 0.286 | 0.065 | 0.799 | 0.240 | 0.624 | 0.047 | 0.829 | 0.089 | 0.765 |
chemo no (all subgroups) | 30 | 0.833 | 0.361 | 3.472 | 0.062 | 0.403 | 0.526 | 1.123 | 0.289 | 0.067 | 0.795 | 0.465 | 0.495 | 0.003 | 0.955 | 0.049 | 0.825 |
chemo yes (all subgroups) | 89 | 6.588 |
0.010
| 10.593 |
0.001
| 0.387 | 0.534 | 0.566 | 0.452 | 2.858 | 0.091 | 7.465 |
0.006
| 0.614 | 0.433 | 0.186 | 0.667 |
chemo (CMF) | 55 | 5.455 |
0.020
| 9.345 |
0.002
| 1.275 | 0.259 | 1.561 | 0.212 | 1.522 | 0.217 | 4.847 |
0.028
| 0.152 | 0.697 | 0.016 | 0.899 |
chemo (AC/CMF) | 34 | 1.289 | 0.256 | 1.608 | 0.205 | 0.420 | 0.517 | 0.317 | 0.574 | 1.300 | 0.254 | 2.740 | 0.098 | 0.507 | 0.477 | 0.456 | 0.500 |
chemo alone | 13 | 1.865 | 0.172 | 1.268 | 0.260 | 0.107 | 0.743 | 0.245 | 0.620 | 0.322 | 0.570 | 1.356 | 0.244 | 0.099 | 0.753 | 0.126 | 0.722 |
chemo and radiation | 39 | 4.123 |
0.042
| 8.229 |
0.004
| 0.898 | 0.344 | 0.209 | 0.648 | 2.380 | 0.123 | 3.271 | 0.071 | 0.431 | 0.512 | 0.180 | 0.672 |
radiation no (all subgroups) | 47 | 1.964 | 0.161 | 3.638 | 0.057 | 0.009 | 0.927 | 0.067 | 0.796 | 0.005 | 0.946 | 0.497 | 0.481 | 1.310 | 0.252 | 1.819 | 0.178 |
radiation yes (all subgroups) | 72 | 3.786 | 0.052 | 8.444 |
0.004
| 1.143 | 0.285 | 1.690 | 0.194 | 2.395 | 0.122 | 4.766 |
0.029
| 0.122 | 0.727 | 0.090 | 0.764 |