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Osteoporosis International

Erschienen in:

01.02.2015 | Review

Osteoporosis therapy: a novel insight from natural homeostatic system in the skeleton

verfasst von: T. Sugiyama, Y. T. Kim, H. Oda

Erschienen in: Osteoporosis International | Ausgabe 2/2015

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Abstract

The skeleton normally responds to mechanical environment to maintain the resulting elastic deformation (strain) of bone, while increased bone strength by an osteoporosis drug results in decreased bone strain. Thus, it can be hypothesized that the effect of osteoporosis therapy is limited by natural homeostatic system in the skeleton. This logic is consistent with the fact that there exists a powerful effect that returns bone mass to its pre-treatment level after the withdrawal of treatment with osteoporosis agents. The present hypothesis provides a new significant insight into the mechanisms by which osteoporosis drugs improve bone fragility. Here we briefly discuss the effects of teriparatide, romosozumab, and odanacatib on bones in animals and humans.

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Titel: Osteoporosis therapy: a novel insight from natural homeostatic system in the skeleton
verfasst von: T. Sugiyama
Y. T. Kim
H. Oda
Publikationsdatum: 01.02.2015
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 2/2015
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-014-2923-y

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