Skip to main content
Erschienen in: Techniques in Coloproctology 6/2014

01.06.2014 | Original Article

Outcomes after biological mesh reconstruction of the pelvic floor following extra-levator abdominoperineal excision of rectum (APER)

verfasst von: O. Peacock, J. A. Simpson, S. I. Tou, N. G. Hurst, W. J. Speake, G. M. Tierney, J. N. Lund

Erschienen in: Techniques in Coloproctology | Ausgabe 6/2014

Einloggen, um Zugang zu erhalten

Abstract

Background

Extra-levator abdominoperineal excision of the rectum (ELAPER) for low rectal cancer is used to avoid the adverse oncological outcomes of inadvertent perforation and a positive circumferential resection margin associated with the conventional APER technique. This wider excision creates a large defect requiring pelvic floor reconstruction, and there is still controversy regarding the best method of closure. The aim of this study is to present outcomes of biological mesh pelvic floor reconstruction following ELAPER.

Methods

Prospective data on consecutive patients having ELAPER for low rectal cancer at a single UK institution between October 2008 and March 2013 were collected. The perineum was reconstructed using a biological mesh and the short-term outcomes were evaluated, focusing particularly on perineal wound complications and perineal hernias.

Results

Thirty-four patients were included [median age 62 years, range 40–72 years, 27 males (79 %)]. The median operative time was 248 min (range 120–340 min). The median length of hospital stay was 9 days (range 4–20 days). There were three perineal complications (9 %) requiring surgical intervention, but no meshes were removed. There were no perineal hernias. The median length of follow-up was 21 months (range 1–54 months). The overall mortality was 9 % from distant metastases.

Conclusions

Our series adds to the increasing evidence that good outcomes can be achieved for pelvic floor reconstruction with biological mesh following ELAPER without the additional use of myocutaneous flaps. The low serious complication rate, good outcomes in perineal wound healing and the absence of perineal hernias demonstrates that this is a safe and feasible procedure.
Literatur
1.
Zurück zum Zitat Wibe A, Syse A, Andersen E, Tretli S, Myrvold HE, Soreide O (2004) Oncological outcomes after total mesorectal excision for cure for cancer of the lower rectum: anterior vs. abdominoperineal resection. Dis Colon Rectum 47:48–58PubMedCrossRef Wibe A, Syse A, Andersen E, Tretli S, Myrvold HE, Soreide O (2004) Oncological outcomes after total mesorectal excision for cure for cancer of the lower rectum: anterior vs. abdominoperineal resection. Dis Colon Rectum 47:48–58PubMedCrossRef
2.
Zurück zum Zitat Nagtegaal ID, van de Velde CJ, Marijnen CA, van Krieken JH, Quirke P (2005) Low rectal cancer: a call for a change of approach in abdominoperineal resection. J Clin Oncol 23:9257–9264PubMedCrossRef Nagtegaal ID, van de Velde CJ, Marijnen CA, van Krieken JH, Quirke P (2005) Low rectal cancer: a call for a change of approach in abdominoperineal resection. J Clin Oncol 23:9257–9264PubMedCrossRef
3.
Zurück zum Zitat Eriksen MT, Wibe A, Syse A, Haffner J, Wiig JN (2004) Inadvertent perforation during rectal cancer resection in Norway. Br J Surg 91:210–216PubMedCrossRef Eriksen MT, Wibe A, Syse A, Haffner J, Wiig JN (2004) Inadvertent perforation during rectal cancer resection in Norway. Br J Surg 91:210–216PubMedCrossRef
4.
Zurück zum Zitat Marr R, Birbeck K, Garvican J et al (2005) The modern abdominoperineal excision: the next challenge after total mesorectal excision. Ann Surg 242:74–82PubMedCentralPubMedCrossRef Marr R, Birbeck K, Garvican J et al (2005) The modern abdominoperineal excision: the next challenge after total mesorectal excision. Ann Surg 242:74–82PubMedCentralPubMedCrossRef
5.
Zurück zum Zitat Anderin C, Martling A, Hellborg H, Holm T (2010) A population-based study on outcome in relation to the type of resection in low rectal cancer. Dis Colon Rectum 53:753–760PubMedCrossRef Anderin C, Martling A, Hellborg H, Holm T (2010) A population-based study on outcome in relation to the type of resection in low rectal cancer. Dis Colon Rectum 53:753–760PubMedCrossRef
6.
Zurück zum Zitat Miles WE (1908) A method of performing abdomino-perineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon. Lancet 2:1812–1813CrossRef Miles WE (1908) A method of performing abdomino-perineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon. Lancet 2:1812–1813CrossRef
7.
Zurück zum Zitat Holm T, Ljung A, Haggmark T, Jurell G, Lagergren J (2007) Extended abdominoperineal resection with gluteus maximus flap reconstruction of the pelvic floor for rectal cancer. Br J Surg 94:232–238PubMedCrossRef Holm T, Ljung A, Haggmark T, Jurell G, Lagergren J (2007) Extended abdominoperineal resection with gluteus maximus flap reconstruction of the pelvic floor for rectal cancer. Br J Surg 94:232–238PubMedCrossRef
8.
Zurück zum Zitat West NP, Finan PJ, Anderin C, Lindholm J, Holm T, Quirke P (2008) Evidence of the oncologic superiority of cylindrical abdominoperineal excision for low rectal cancer. J Clin Oncol 26:3517–3522PubMedCrossRef West NP, Finan PJ, Anderin C, Lindholm J, Holm T, Quirke P (2008) Evidence of the oncologic superiority of cylindrical abdominoperineal excision for low rectal cancer. J Clin Oncol 26:3517–3522PubMedCrossRef
9.
Zurück zum Zitat West NP, Anderin C, Smith KJ, Holm T, Quirke P (2010) Multicentre experience with extralevator abdominoperineal excision for low rectal cancer. Br J Surg 97:588–599PubMedCrossRef West NP, Anderin C, Smith KJ, Holm T, Quirke P (2010) Multicentre experience with extralevator abdominoperineal excision for low rectal cancer. Br J Surg 97:588–599PubMedCrossRef
10.
Zurück zum Zitat Nisar PJ, Scott HJ (2009) Myocutaneous flap reconstruction of the pelvis after abdominoperineal excision. Colorectal Dis 11:806–816PubMedCrossRef Nisar PJ, Scott HJ (2009) Myocutaneous flap reconstruction of the pelvis after abdominoperineal excision. Colorectal Dis 11:806–816PubMedCrossRef
11.
Zurück zum Zitat Bullard KM, Trudel JL, Baxter NN, Rothenberger DA (2005) Primary perineal wound closure after preoperative radiotherapy and abdominoperineal resection has a high incidence of wound failure. Dis Colon Rectum 48:438–443PubMedCrossRef Bullard KM, Trudel JL, Baxter NN, Rothenberger DA (2005) Primary perineal wound closure after preoperative radiotherapy and abdominoperineal resection has a high incidence of wound failure. Dis Colon Rectum 48:438–443PubMedCrossRef
12.
Zurück zum Zitat Artioukh DY, Smith RA, Gokul K (2007) Risk factors for impaired healing of the perineal wound after abdominoperineal resection of rectum for carcinoma. Colorectal Dis 9:362–367PubMedCrossRef Artioukh DY, Smith RA, Gokul K (2007) Risk factors for impaired healing of the perineal wound after abdominoperineal resection of rectum for carcinoma. Colorectal Dis 9:362–367PubMedCrossRef
13.
Zurück zum Zitat Barker JA, Blackmore AE, Owen RP, Rate A (2013) Prone cylindrical abdominoperineal resection with subsequent rectus abdominis myocutaneous flap reconstruction performed by a colorectal surgeon. Int J Colorectal Dis 28:801–806PubMedCrossRef Barker JA, Blackmore AE, Owen RP, Rate A (2013) Prone cylindrical abdominoperineal resection with subsequent rectus abdominis myocutaneous flap reconstruction performed by a colorectal surgeon. Int J Colorectal Dis 28:801–806PubMedCrossRef
14.
Zurück zum Zitat Hainsworth A, Al Akash M, Roblin P, Mohanna P, Ross D, George ML (2012) Perineal reconstruction after abdominoperineal excision using inferior gluteal artery perforator flaps. Br J Surg 99:584–588PubMedCrossRef Hainsworth A, Al Akash M, Roblin P, Mohanna P, Ross D, George ML (2012) Perineal reconstruction after abdominoperineal excision using inferior gluteal artery perforator flaps. Br J Surg 99:584–588PubMedCrossRef
15.
Zurück zum Zitat Anderin C, Martling A, Lagergren J, Ljung A, Holm T (2012) Short-term outcome after gluteus maximus myocutaneous flap reconstruction of the pelvic floor following extra-levator abdominoperineal excision of the rectum. Colorectal Dis 14:1060–1064PubMedCrossRef Anderin C, Martling A, Lagergren J, Ljung A, Holm T (2012) Short-term outcome after gluteus maximus myocutaneous flap reconstruction of the pelvic floor following extra-levator abdominoperineal excision of the rectum. Colorectal Dis 14:1060–1064PubMedCrossRef
16.
Zurück zum Zitat Wille-Jorgensen P, Pilsgaard B, Moller P (2009) Reconstruction of the pelvic floor with a biological mesh after abdominoperineal excision for rectal cancer. Int J Colorectal Dis 24:323–325PubMedCrossRef Wille-Jorgensen P, Pilsgaard B, Moller P (2009) Reconstruction of the pelvic floor with a biological mesh after abdominoperineal excision for rectal cancer. Int J Colorectal Dis 24:323–325PubMedCrossRef
17.
Zurück zum Zitat Christensen HK, Nerstrom P, Tei T, Laurberg S (2011) Perineal repair after extralevator abdominoperineal excision for low rectal cancer. Dis Colon Rectum 54:711–717PubMedCrossRef Christensen HK, Nerstrom P, Tei T, Laurberg S (2011) Perineal repair after extralevator abdominoperineal excision for low rectal cancer. Dis Colon Rectum 54:711–717PubMedCrossRef
18.
Zurück zum Zitat Dalton RS, Smart NJ, Edwards TJ, Chandler I, Daniels IR (2012) Short-term outcomes of the prone perineal approach for extra-levator abdomino-perineal excision (elAPE). Surgeon 10:342–346PubMedCrossRef Dalton RS, Smart NJ, Edwards TJ, Chandler I, Daniels IR (2012) Short-term outcomes of the prone perineal approach for extra-levator abdomino-perineal excision (elAPE). Surgeon 10:342–346PubMedCrossRef
19.
Zurück zum Zitat Boereboom CL, Watson NF, Sivakumar R, Hurst NG, Speake WJ (2009) Biological tissue graft for pelvic floor reconstruction after cylindrical abdominoperineal excision of the rectum and anal canal. Tech Coloproctol 13:257–258PubMedCrossRef Boereboom CL, Watson NF, Sivakumar R, Hurst NG, Speake WJ (2009) Biological tissue graft for pelvic floor reconstruction after cylindrical abdominoperineal excision of the rectum and anal canal. Tech Coloproctol 13:257–258PubMedCrossRef
20.
Zurück zum Zitat Peacock O, Pandya H, Sharp T et al (2012) Biological mesh reconstruction of perineal wounds following enhanced abdominoperineal excision of rectum (APER). Int J Colorectal Dis 27:475–482PubMedCrossRef Peacock O, Pandya H, Sharp T et al (2012) Biological mesh reconstruction of perineal wounds following enhanced abdominoperineal excision of rectum (APER). Int J Colorectal Dis 27:475–482PubMedCrossRef
22.
Zurück zum Zitat Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213PubMedCentralPubMedCrossRef Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213PubMedCentralPubMedCrossRef
23.
Zurück zum Zitat Marshall MJ, Smart NJ, Daniels IR (2012) Biologic meshes in perineal reconstruction following extra-levator abdominoperineal excision (elAPE). Colorectal Dis 14(Suppl 3):12–18PubMedCrossRef Marshall MJ, Smart NJ, Daniels IR (2012) Biologic meshes in perineal reconstruction following extra-levator abdominoperineal excision (elAPE). Colorectal Dis 14(Suppl 3):12–18PubMedCrossRef
24.
Zurück zum Zitat Dabbas N, Adams K, Chave H, Branagan G (2012) Current practice in abdominoperineal resection: an email survey of the membership of the Association of Coloproctology. Ann R Coll Surg Engl 94:173–176PubMedCentralPubMedCrossRef Dabbas N, Adams K, Chave H, Branagan G (2012) Current practice in abdominoperineal resection: an email survey of the membership of the Association of Coloproctology. Ann R Coll Surg Engl 94:173–176PubMedCentralPubMedCrossRef
25.
Zurück zum Zitat Rothenberger DA, Wong WD (1992) Abdominoperineal resection for adenocarcinoma of the low rectum. World J Surg 16:478–485PubMedCrossRef Rothenberger DA, Wong WD (1992) Abdominoperineal resection for adenocarcinoma of the low rectum. World J Surg 16:478–485PubMedCrossRef
26.
Zurück zum Zitat van der Wal BC, Cleffken BI, Gulec B, Kaufman HS, Choti MA (2001) Results of salvage abdominoperineal resection for recurrent anal carcinoma following combined chemoradiation therapy. J Gastrointest Surg 5:383–387PubMedCrossRef van der Wal BC, Cleffken BI, Gulec B, Kaufman HS, Choti MA (2001) Results of salvage abdominoperineal resection for recurrent anal carcinoma following combined chemoradiation therapy. J Gastrointest Surg 5:383–387PubMedCrossRef
27.
Zurück zum Zitat Khoo AK, Skibber JM, Nabawi AS et al (2001) Indications for immediate tissue transfer for soft tissue reconstruction in visceral pelvic surgery. Surgery 130:463–469PubMedCrossRef Khoo AK, Skibber JM, Nabawi AS et al (2001) Indications for immediate tissue transfer for soft tissue reconstruction in visceral pelvic surgery. Surgery 130:463–469PubMedCrossRef
28.
Zurück zum Zitat Kapoor V, Cole J, Isik FF, Sinanan M, Flum D (2005) Does the use of a flap during abdominoperineal resection decrease pelvic wound morbidity? Am Surg 71:117–122PubMed Kapoor V, Cole J, Isik FF, Sinanan M, Flum D (2005) Does the use of a flap during abdominoperineal resection decrease pelvic wound morbidity? Am Surg 71:117–122PubMed
29.
Zurück zum Zitat Hendren SK, Swallow CJ, Smith A et al (2007) Complications and sexual function after vaginectomy for anorectal tumors. Dis Colon Rectum 50:810–816PubMedCrossRef Hendren SK, Swallow CJ, Smith A et al (2007) Complications and sexual function after vaginectomy for anorectal tumors. Dis Colon Rectum 50:810–816PubMedCrossRef
30.
Zurück zum Zitat Foster JD, Pathak S, Smart NJ et al (2012) Reconstruction of the perineum following extralevator abdominoperineal excision for carcinoma of the lower rectum: a systematic review. Colorectal Dis 14:1052–1059PubMedCrossRef Foster JD, Pathak S, Smart NJ et al (2012) Reconstruction of the perineum following extralevator abdominoperineal excision for carcinoma of the lower rectum: a systematic review. Colorectal Dis 14:1052–1059PubMedCrossRef
31.
Zurück zum Zitat Konstantinovic ML, Lagae P, Zheng F, Verbeken EK, De Ridder D, Deprest JA (2005) Comparison of host response to polypropylene and non-cross-linked porcine small intestine serosal-derived collagen implants in a rat model. BJOG 112:1554–1560PubMedCrossRef Konstantinovic ML, Lagae P, Zheng F, Verbeken EK, De Ridder D, Deprest JA (2005) Comparison of host response to polypropylene and non-cross-linked porcine small intestine serosal-derived collagen implants in a rat model. BJOG 112:1554–1560PubMedCrossRef
32.
Zurück zum Zitat Ayubi FS, Armstrong PJ, Mattia MS, Parker DM (2008) Abdominal wall hernia repair: a comparison of Permacol and Surgisis grafts in a rat hernia model. Hernia 12:373–378PubMedCrossRef Ayubi FS, Armstrong PJ, Mattia MS, Parker DM (2008) Abdominal wall hernia repair: a comparison of Permacol and Surgisis grafts in a rat hernia model. Hernia 12:373–378PubMedCrossRef
33.
Zurück zum Zitat Vaughan-Shaw PG, Cheung T, Knight JS, Nichols PH, Pilkington SA, Mirnezami AH (2012) A prospective case-control study of extralevator abdominoperineal excision (ELAPE) of the rectum versus conventional laparoscopic and open abdominoperineal excision: comparative analysis of short-term outcomes and quality of life. Tech Coloproctol 16:355–362PubMedCrossRef Vaughan-Shaw PG, Cheung T, Knight JS, Nichols PH, Pilkington SA, Mirnezami AH (2012) A prospective case-control study of extralevator abdominoperineal excision (ELAPE) of the rectum versus conventional laparoscopic and open abdominoperineal excision: comparative analysis of short-term outcomes and quality of life. Tech Coloproctol 16:355–362PubMedCrossRef
34.
Zurück zum Zitat Han JG, Wang ZJ, Gao ZG, Xu HM, Yang ZH, Jin ML (2010) Pelvic floor reconstruction using human acellular dermal matrix after cylindrical abdominoperineal resection. Dis Colon Rectum 53:219–223PubMedCrossRef Han JG, Wang ZJ, Gao ZG, Xu HM, Yang ZH, Jin ML (2010) Pelvic floor reconstruction using human acellular dermal matrix after cylindrical abdominoperineal resection. Dis Colon Rectum 53:219–223PubMedCrossRef
35.
Zurück zum Zitat Han JG, Wang ZJ, Wei GH, Gao ZG, Yang Y, Zhao BC (2012) Randomized clinical trial of conventional versus cylindrical abdominoperineal resection for locally advanced lower rectal cancer. Am J Surg 204:274–282PubMedCrossRef Han JG, Wang ZJ, Wei GH, Gao ZG, Yang Y, Zhao BC (2012) Randomized clinical trial of conventional versus cylindrical abdominoperineal resection for locally advanced lower rectal cancer. Am J Surg 204:274–282PubMedCrossRef
36.
Zurück zum Zitat Jin J, Rosen MJ, Blatnik J et al (2007) Use of acellular dermal matrix for complicated ventral hernia repair: does technique affect outcomes? J Am Coll Surg 205:654–660PubMedCrossRef Jin J, Rosen MJ, Blatnik J et al (2007) Use of acellular dermal matrix for complicated ventral hernia repair: does technique affect outcomes? J Am Coll Surg 205:654–660PubMedCrossRef
37.
Zurück zum Zitat Rice RD, Ayubi FS, Shaub ZJ, Parker DM, Armstrong PJ, Tsai JW (2010) Comparison of Surgisis, AlloDerm, and Vicryl Woven Mesh grafts for abdominal wall defect repair in an animal model. Aesthet Plast Surg 34:290–296CrossRef Rice RD, Ayubi FS, Shaub ZJ, Parker DM, Armstrong PJ, Tsai JW (2010) Comparison of Surgisis, AlloDerm, and Vicryl Woven Mesh grafts for abdominal wall defect repair in an animal model. Aesthet Plast Surg 34:290–296CrossRef
38.
Zurück zum Zitat Chan S, Miller M, Ng R et al (2010) Use of myocutaneous flaps for perineal closure following abdominoperineal excision of the rectum for adenocarcinoma. Colorectal Dis 12:555–560PubMedCrossRef Chan S, Miller M, Ng R et al (2010) Use of myocutaneous flaps for perineal closure following abdominoperineal excision of the rectum for adenocarcinoma. Colorectal Dis 12:555–560PubMedCrossRef
Metadaten
Titel
Outcomes after biological mesh reconstruction of the pelvic floor following extra-levator abdominoperineal excision of rectum (APER)
verfasst von
O. Peacock
J. A. Simpson
S. I. Tou
N. G. Hurst
W. J. Speake
G. M. Tierney
J. N. Lund
Publikationsdatum
01.06.2014
Verlag
Springer Milan
Erschienen in
Techniques in Coloproctology / Ausgabe 6/2014
Print ISSN: 1123-6337
Elektronische ISSN: 1128-045X
DOI
https://doi.org/10.1007/s10151-013-1107-7

Weitere Artikel der Ausgabe 6/2014

Techniques in Coloproctology 6/2014 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.