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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

17.08.2018 | Original Article

Outcomes of Clostridium difficile-suspected diarrhea in a French university hospital

verfasst von: Nagham Khanafer, Philippe Vanhems, Frédéric Barbut, Catherine Eckert, Michel Perraud, François Vandenesch, Christine Luxemburger, Clarisse Demont, CDI01 Study Group

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 11/2018

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Abstract

Clostridium difficile infection (CDI) produces a variety of clinical presentations ranging from mild diarrhea to severe infection with fulminant colitis, septic shock, and death. CDI puts a heavy burden on healthcare systems due to increased morbidity and mortality, and higher costs. We evaluated the clinical impact of CDI in terms of complications and mortality in a French university hospital compared with patients with diarrhea unrelated to CDI. A 3-year prospective, observational, cohort study was conducted in a French university hospital. Inpatients aged 18 years or older with CDI-suspected diarrhea were eligible to participate in the study and were followed for up to 60 days after CDI testing. Among the 945 patients with diarrhea included, 233 had confirmed CDI. Overall, 106 patients (11.2%) developed at least one of the following complications: colectomy, colitis, ileitis/rectitis, ileus, intestinal perforation, megacolon, multiorgan failure, pancolitis, peritonitis, pseudomembranous colitis, renal failure, and sepsis/septic shock. The complication rate was significantly higher in patients with diarrhea related to C. difficile than in non-CDI patients (26.6% vs 6.2%, P < 0.001). At day 60, 137 (14.5%) patients had died, with 37 deaths among the CDI group (15.9%). Death was attributable to CDI in 15 patients (6.4%). Complications are more frequent among CDI cases than in patients with diarrhea not related to C. difficile. Assessment of CDI is necessary to ensure allocation of sufficient resources to CDI prevention.

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Titel: Outcomes of Clostridium difficile-suspected diarrhea in a French university hospital
verfasst von: Nagham Khanafer
Philippe Vanhems
Frédéric Barbut
Catherine Eckert
Michel Perraud
François Vandenesch
Christine Luxemburger
Clarisse Demont
CDI01 Study Group
Publikationsdatum: 17.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 11/2018
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-018-3348-x

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Outcomes of Clostridium difficile-suspected diarrhea in a French university hospital

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Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

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