Outcomes of Simultaneous Resection of Small Bowel Neuroendocrine Tumors with Synchronous Liver Metastases
- 16.03.2020
- Original Scientific Report
Erschienen in:
- Verfasst von
- Pietro Addeo
- Jean-Baptiste Bertin
- Alessio Imperiale
- Gerlinde Averous
- Alfonso Terrone
- Bernard Goichot
- Philippe Bachellier
- Erschienen in
- World Journal of Surgery | Ausgabe 7/2020
Abstract
Background
This study evaluated the short- and long-term outcomes of synchronous resection of liver metastases (LM) from small bowel neuroendocrine tumors (SB-NET).
Methods
A retrospective review of patients undergoing resection for LMs from SB-NETs from January 1997 and December 2018 was performed.
Results
There were 44 patients with synchronous SB-NET and LMs. Perioperative and 90-day mortality values were zero, and the morbidity rate was 27%. The median overall survival (OS) was 128.4 months (CI 95% 74.0–161.5 months) with 1-, 3-, 5-, and 10-year survival rates of 100%, 83%, 79%, and 60%, respectively. Not achieving surgical treatment for LM was the unique independent factor for survival (HR 6.50; CI 95% 1.54–27.28; p = 0.01) in patients with unresected LMs having OS and 10-year survival rates (42 months, 33%) versus patients undergoing liver resection (152 months, 66%)(p = 0.0008). The recurrence rate was 81.8% and associated with longer OS and 5-year survival rates when limited to the liver [223 months (61%) vs 94 months (87%)].
Conclusions
Simultaneous resection of SB-NETs with synchronous LMs was safe and associated with considerable long-term survival even in the presence of bilobar disease. However, recurrence after resection was common (81%) but associated with longer survival rates when limited to the liver.
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- Titel
- Outcomes of Simultaneous Resection of Small Bowel Neuroendocrine Tumors with Synchronous Liver Metastases
- Verfasst von
-
Pietro Addeo
Jean-Baptiste Bertin
Alessio Imperiale
Gerlinde Averous
Alfonso Terrone
Bernard Goichot
Philippe Bachellier
- Publikationsdatum
- 16.03.2020
- Verlag
- Springer International Publishing
- Erschienen in
-
World Journal of Surgery / Ausgabe 7/2020
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323 - DOI
- https://doi.org/10.1007/s00268-020-05467-5
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