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23.05.2016 | Retinal Disorders | Ausgabe 11/2016

Graefe's Archive for Clinical and Experimental Ophthalmology 11/2016

Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 11/2016
Autoren:
Satoshi Katagiri, Tadashi Yokoi, Masashi Mikami, Sachiko Nishina, Noriyuki Azuma
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00417-016-3385-z) contains supplementary material, which is available to authorized users.

Abstract

Purpose

To investigate the relationship between vision and foveal maturity, especially in foveal hypoplasia exhibiting severe structural immaturity.

Methods

This retrospective observational case series included 42 eyes of 23 patients (mean age, 7.0 ± 5.0 years; 9 patients with foveal hypoplasia as an isolated entity and 14 patients with aniridia). A complete ophthalmic examination included measurement of best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT). The sensory retina, ganglion cell complex (GCC), and outer retinal layers, including Henle’s fiber layer (HFL), were measured and analyzed.

Results

Using SD-OCT images, eyes were classified as having a differentiated (6 eyes), diffuse (19 eyes), or no HFL (17 eyes), based on the appearance of the HFL around the foveal region. The logMAR BCVA was significantly worse (p < 0.0001) in eyes with diffuse HFL and those with no HFL than in those with differentiated HFL. Outer retinal thickness (outer plexiform layer + HFL + outer nuclear layer) was less (p = 0.0051) in eyes with no HFL than in those with differentiated HFL. The logMAR BCVA, GCC thickness, and outer retinal thickness in eyes with foveal hypoplasia with aniridia were significantly worse (p = 0.0083), thicker (p = 0.0039), and thinner (p = 0.0001), respectively, than in eyes with foveal hypoplasia as an isolated entity.

Conclusions

In eyes with foveal hypoplasia with severe structural immaturity, diffuse HFL or no HFL was associated with worse vision. There was greater foveal immaturity in eyes with foveal hypoplasia with aniridia compared with foveal hypoplasia as an isolated entity.

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