Erschienen in:
01.10.2014
Oxidative Stress and Inflammation Are Differentially Affected by Atorvastatin, Pravastatin, Rosuvastatin, and Simvastatin on Lungs from Mice Exposed to Cigarette Smoke
verfasst von:
Thiago Santos Ferreira, Manuella Lanzetti, Marina Valente Barroso, Carlos Romualdo Rueff-Barroso, Cláudia Farias Benjamim, Lycia de Brito-Gitirana, Luís Cristóvão Porto, Samuel Santos Valença
Erschienen in:
Inflammation
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Ausgabe 5/2014
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Abstract
Our aim was to investigate the effects of four different statins on acute lung inflammation induced by cigarette smoke (CS). C57BL/6 male mice were divided into a control group (sham-smoked) and mice exposed to CS from 12 cigarettes/day for 5 days. Mice exposed to CS were grouped and treated with vehicle (i.p.), atorvastatin (10 mg/kg), pravastatin (10 mg/kg), rosuvastatin (5 mg/kg), or simvastatin (20 mg/kg). Treatment with statins differentially improved the pulmonary response when compared to the CS group. Atorvastatin and pravastatin demonstrated slightly effects on inflammation and oxidative stress. Rosuvastatin demonstrated the best anti-inflammatory effect, whereas simvastatin demonstrated the best antioxidant response.