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Journal of Assisted Reproduction and Genetics

Erschienen in:

20.08.2016 | Letter to the Editor

Oxidative stress and the etiology of male infertility

verfasst von: R. J. Aitken

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 12/2016

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Excerpt

One of the few insights we have gained into the etiology of male infertility over the past 20 years has been the realization that these cells, and the precious cargos they carry, are extremely vulnerable to oxidative stress [1]. Furthermore, the fact that antioxidant therapy seems to have a beneficial impact on semen quality suggests that such stress does not just correlate with defective sperm function but is causally involved in its genesis [2, 3]. However, one of the fundamental questions that remains is the actual mechanism by which reactive oxygen species (ROS) are generated in cases male infertility. …

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De Iuliis GN, Thomson LK, Mitchell LA, Finnie JM, Koppers AJ, Hedges A, et al. DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidative stress. Biol Reprod. 2009;81(3):517–24.CrossRefPubMed

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Koppers AJ, De Iuliis GN, Finnie JM, McLaughlin EA, Aitken RJ. Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa. J Clin Endocrinol Metab. 2008;93(8):3199–207.CrossRefPubMed

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Pelliccione F, D’Angeli A, Cordeschi G, Mihalca R, Ciociola F, Necozione S, et al. Francavilla seminal macrophages in ejaculates from men with couple infertility. Int J Androl. 2009;32(6):623–8.CrossRefPubMed

Titel: Oxidative stress and the etiology of male infertility
verfasst von: R. J. Aitken
Publikationsdatum: 20.08.2016
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 12/2016
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-016-0791-4

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