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01.12.2014 | Research article | Ausgabe 1/2014 Open Access

BMC Palliative Care 1/2014

Oxidative stress level is not associated with survival in terminally ill cancer patients: a preliminary study

BMC Palliative Care > Ausgabe 1/2014
Chang Hwan Yeom, Youn Seon Choi, Hong Yup Ahn, Su Hey Lee, In Cheol Hwang
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1472-684X-13-14) contains supplementary material, which is available to authorized users.
Chang Hwan Yeom, Youn Seon Choi contributed equally to this work.

Competing interests

CHY is the chairperson of the Korean Association for Vitamin Research. All authors have no potential conflicts of interest concerning this article.

Authors’ contributions

CHY, YSC, and ICH designed study. CHY, YSC and ICH wrote the manuscript. YSC, SHL and ICH conducted study and collected the data. AHY and ICH analysed the data. CHY, YSC and ICH interpreted the data. All authors read and approved the final manuscript.



While cancer patients have higher oxidative stress (OS) and lower antioxidant activity, evidence for the association of these parameters with survival in patients with terminally ill cancer is lacking.


We followed 65 terminal cancer patients prospectively. We assessed their performance status, some symptoms, and serum levels of vitamin C and OS level. The Gehan’s generalized Wilcoxon test was used to examine the association between survival times and variables.


Subjects’ performance status was very poor and they had a high level of OS and a low level of vitamin C. No significant association of these two parameters with survival time was noted (p-value, 0.637 for high OS and 0.240 for low vitamin C). Poor performance status was independently related to high OS status after adjusting for potential confounders (adjusted OR, 4.45; p-value, 0.031).


In this study, OS was not associated with survival of terminally ill cancer patients and its prognostic role requires further study.
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