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Erschienen in: Clinical and Experimental Nephrology 2/2017

27.05.2016 | Original Article

Oxidative stress markers in type 2 diabetes patients with diabetic nephropathy

verfasst von: Su-Tze Chou, Shih-Ting Tseng

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 2/2017

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Abstract

Background

Epidemiological studies show that 5–40 % of type 2 diabetes (T2DM) patients have diabetic nephropathy, and oxidative stress is one of several underlying mechanisms. We investigated associations between oxidative stress markers and severity of diabetic nephropathy.

Methods

Fifty-nine T2DM patients from the endocrinology outpatient department were included, and their levels of oxidative stress markers were measured. Three groups were determined by their urine albumin-to-creatinine ratio (UACR): group A (UACR < 30 mg/g, n = 22); group B (30 ≤ UACR < 300 mg/g, n = 22); and group C (UACR ≥ 300 mg/g, n = 15).

Results

Vitamin C levels correlated negatively and moderately with serum creatinine (γ = −0.459, p < 0.001), urine albumin (γ s = −0.458, p = 0.001) and UACR (γ s = −0.408, p = 0.001), but only weakly with hydroxy-2-deoxyguanosine (8-OHdG) and estimated glomerular filtration rate (eGFR). Vitamin C levels decreased as 8-OHdG, serum creatinine, albumin and UACR increased. T2DM patients with more severe diabetic nephropathy had lower vitamin C levels.

Conclusion

Our results identified several oxidative stress markers that may be clinically important in diabetic nephropathy. Studies with larger sample sizes should be undertaken to confirm these findings.
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Metadaten
Titel
Oxidative stress markers in type 2 diabetes patients with diabetic nephropathy
verfasst von
Su-Tze Chou
Shih-Ting Tseng
Publikationsdatum
27.05.2016
Verlag
Springer Japan
Erschienen in
Clinical and Experimental Nephrology / Ausgabe 2/2017
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-016-1283-7

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