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Erschienen in: Heart and Vessels 1/2011

01.01.2011 | Original Article

Oxidative stress versus antioxidant defenses in patients with acute myocardial infarction

verfasst von: Margarete Dulce Bagatini, Caroline Curry Martins, Vanessa Battisti, Diogo Gasparetto, Cintia Saydelles da Rosa, Roselia Maria Spanevello, Mushtaq Ahmed, Roberta Schmatz, Maria Rosa Chitolina Schetinger, Vera Maria Morsch

Erschienen in: Heart and Vessels | Ausgabe 1/2011

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Abstract

Acute myocardial infarction (AMI) is a highly dynamic event, which is associated with increasing production of reactive oxygen species (ROS). The imbalance between ROS production and antioxidant defenses leads to the condition known as oxidative stress. The most widely recognized effect of increasing oxidative stress is the oxidation and damage of macromolecules, membranes, proteins, and DNA. Therefore, in this study we sought to evaluate oxidative stress and antioxidant defenses in patients with AMI. Lipid peroxidation, protein carbonyl levels, and enzymatic and nonenzymatic antioxidants were assessed in samples obtained from 40 AMI patients and 40 control patients. AMI was characterized by clinical, electrocardiographic, and laboratory criteria. The control group was divided into two groups of 20 patients: a control group with healthy patients and a risk group. Our results demonstrated an increase in substances reactive to thiobarbituric acid (TBARS) and carbonyl protein levels in the AMI and risk groups. In addition, a positive correlation was found between TBARS, carbonyl protein levels, and troponin I in AMI patients. Surprisingly, for the enzymatic antioxidant defenses, catalase and superoxide dismutase, we observed an increase in these parameters in the AMI and risk groups when compared with healthy patients. However, a decrease in nonenzymatic antioxidants such as vitamin C and vitamin E was observed in AMI patients when compared with the healthy group and the risk group. The increase in oxidative stress was probably a result of the elevation in ROS production due to the ischemic/reperfusion event that occurs in AMI, in addition to the decrease of nonenzymatic antioxidant defenses.
Literatur
1.
Zurück zum Zitat Hackam DG, Anand SS (2003) Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. JAMA 290:932–940CrossRefPubMed Hackam DG, Anand SS (2003) Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. JAMA 290:932–940CrossRefPubMed
2.
Zurück zum Zitat Levi F, Lucchini F, Negri E, La Vecchia C (2002) Trends in mortality from cardiovascular and cerebrovascular diseases in Europe and other areas of the world. Heart 88:119–124CrossRefPubMed Levi F, Lucchini F, Negri E, La Vecchia C (2002) Trends in mortality from cardiovascular and cerebrovascular diseases in Europe and other areas of the world. Heart 88:119–124CrossRefPubMed
3.
Zurück zum Zitat Kasper DN, Braunwald E, Fauci AS, Hauser S, Longo DL, Jameson JL (2006) Harrison medicina interna, 16th ed edn. Academic Press, Rio de Janeiro Kasper DN, Braunwald E, Fauci AS, Hauser S, Longo DL, Jameson JL (2006) Harrison medicina interna, 16th ed edn. Academic Press, Rio de Janeiro
4.
Zurück zum Zitat Espat NJ, Nelton WS (2000) Oxygen free radicals, oxidative stress, and antioxidants in critical illness. Support Line 22:11–20 Espat NJ, Nelton WS (2000) Oxygen free radicals, oxidative stress, and antioxidants in critical illness. Support Line 22:11–20
5.
Zurück zum Zitat Kasparova S, Brezova V, Valko M, Horecký J, Mlynárik V, Liptaj T, Vancová O, Ulicná O, Dobrota D (2005) Study of the oxidative stress in a rat model of chronic brain hypoperfusion. Neurochem Int 46:601–611CrossRefPubMed Kasparova S, Brezova V, Valko M, Horecký J, Mlynárik V, Liptaj T, Vancová O, Ulicná O, Dobrota D (2005) Study of the oxidative stress in a rat model of chronic brain hypoperfusion. Neurochem Int 46:601–611CrossRefPubMed
6.
Zurück zum Zitat Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B, Drexler H (2002) Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure. Role of xanthine oxidase and extracellular superoxide dismutase. Circulation 106:3073–3078CrossRefPubMed Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B, Drexler H (2002) Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure. Role of xanthine oxidase and extracellular superoxide dismutase. Circulation 106:3073–3078CrossRefPubMed
7.
Zurück zum Zitat Giordano FJ (2005) Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115:500–508PubMed Giordano FJ (2005) Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115:500–508PubMed
8.
Zurück zum Zitat Donne ID, Rossi R, Giustarini D, Milzani A, Colombo R (2003) Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta 329:23–38CrossRef Donne ID, Rossi R, Giustarini D, Milzani A, Colombo R (2003) Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta 329:23–38CrossRef
9.
Zurück zum Zitat Lazzarino G, Raatikainen P, Nuutinen M, Nissinen J, Tavazzi B, Di Pierro D, Giardina B, Peuhkurinen K (1994) Myocardial release of malondialdehyde and purine compounds during coronary bypass surgery. Circulation 90:291–297PubMed Lazzarino G, Raatikainen P, Nuutinen M, Nissinen J, Tavazzi B, Di Pierro D, Giardina B, Peuhkurinen K (1994) Myocardial release of malondialdehyde and purine compounds during coronary bypass surgery. Circulation 90:291–297PubMed
10.
Zurück zum Zitat Dhalla NS, Elmoselhi AB, Hatac T, Makino N (2000) Status of myocardial antioxidants in ischemia–reperfusion injury. Cardiovasc Res 47:446–456CrossRefPubMed Dhalla NS, Elmoselhi AB, Hatac T, Makino N (2000) Status of myocardial antioxidants in ischemia–reperfusion injury. Cardiovasc Res 47:446–456CrossRefPubMed
11.
Zurück zum Zitat Halliwell B, Gutterdige JMC (1999) Free radicals in biology and medicine. Oxford University Press, Oxford Halliwell B, Gutterdige JMC (1999) Free radicals in biology and medicine. Oxford University Press, Oxford
12.
Zurück zum Zitat Frei B, England L, Ames BN (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci 88:6377–6381CrossRef Frei B, England L, Ames BN (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci 88:6377–6381CrossRef
13.
Zurück zum Zitat Canbaz S, Duran E, Ege T, Sunar H, Cikirikcioglu M, Acipayam M (2003) The effect of intracoronary administration of vitamin E on myocardial ischemia-reperfusion injury during coronary artery surgery. Thorac Cardiovasc Surg 51:57–61CrossRefPubMed Canbaz S, Duran E, Ege T, Sunar H, Cikirikcioglu M, Acipayam M (2003) The effect of intracoronary administration of vitamin E on myocardial ischemia-reperfusion injury during coronary artery surgery. Thorac Cardiovasc Surg 51:57–61CrossRefPubMed
14.
Zurück zum Zitat Moens AL, Claeys MJ, Timmermans JP, Vrints CJ (2005) Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process. Int J Cardiol 100:179–190CrossRefPubMed Moens AL, Claeys MJ, Timmermans JP, Vrints CJ (2005) Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process. Int J Cardiol 100:179–190CrossRefPubMed
15.
Zurück zum Zitat Thygesen K, Alpert JS, White HD (2007) Universal definition of myocardial infarction. J Am Coll Cardiol 50:2173–2195CrossRefPubMed Thygesen K, Alpert JS, White HD (2007) Universal definition of myocardial infarction. J Am Coll Cardiol 50:2173–2195CrossRefPubMed
16.
Zurück zum Zitat Levini RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186:464–478CrossRef Levini RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186:464–478CrossRef
17.
Zurück zum Zitat Jentzsch AM, Bachmann H, Furst P, Biesalski HK (1996) Improved analysis of malondialdehyde in human body fluids. Free Radic Biol Med 20:251–256CrossRefPubMed Jentzsch AM, Bachmann H, Furst P, Biesalski HK (1996) Improved analysis of malondialdehyde in human body fluids. Free Radic Biol Med 20:251–256CrossRefPubMed
18.
Zurück zum Zitat Nelson DP, Kiesow LA (1972) Enthalpy of decomposition of hydrogen peroxide by catalase at 25°C (with molar extinction coefficients of H2O2 solutions in the UV). Anal Biochem 49:474–478CrossRefPubMed Nelson DP, Kiesow LA (1972) Enthalpy of decomposition of hydrogen peroxide by catalase at 25°C (with molar extinction coefficients of H2O2 solutions in the UV). Anal Biochem 49:474–478CrossRefPubMed
19.
Zurück zum Zitat Mc Cord JM, Fridovich I (1969) Superoxide dismutase: an enzymatic function for erythrocuprein (hemocuprein). J Biol Chem 244:6049–6055 Mc Cord JM, Fridovich I (1969) Superoxide dismutase: an enzymatic function for erythrocuprein (hemocuprein). J Biol Chem 244:6049–6055
20.
Zurück zum Zitat Jacques-Silva MC, Nogueira CW, Broch LC, Flores EMM, Rocha JBT (2001) Diphenil diselenide and ascorbic changes deposition of selenium and ascorbic acid in liver and brain of mice. Pharmacolol Toxicol 88:119–125CrossRef Jacques-Silva MC, Nogueira CW, Broch LC, Flores EMM, Rocha JBT (2001) Diphenil diselenide and ascorbic changes deposition of selenium and ascorbic acid in liver and brain of mice. Pharmacolol Toxicol 88:119–125CrossRef
21.
Zurück zum Zitat Hansen LG, Warwick WJ (1969) A fluorometric micromethod for serum vitamins A and E. Am J Clin Pathol 51:538–541 Hansen LG, Warwick WJ (1969) A fluorometric micromethod for serum vitamins A and E. Am J Clin Pathol 51:538–541
22.
Zurück zum Zitat Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:218–254CrossRef Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:218–254CrossRef
23.
Zurück zum Zitat Kloner RA, Ellis SG, Lange R, Braunwald E (1983) Studies of experimental coronary artery reperfusion. Effects on infarct size, myocardial function, biochemistry, ultrastructure and microvascular damage. Circulation 68:8–15 Kloner RA, Ellis SG, Lange R, Braunwald E (1983) Studies of experimental coronary artery reperfusion. Effects on infarct size, myocardial function, biochemistry, ultrastructure and microvascular damage. Circulation 68:8–15
24.
Zurück zum Zitat Antman EM, Tanasijevic MJ, Thompson B, Schactman M, McCabe CH, Cannon CP, Fischer GA, Fung AY, Thompson C, Wybenga D, Braunwald E (1996) Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 335:1342–1349CrossRefPubMed Antman EM, Tanasijevic MJ, Thompson B, Schactman M, McCabe CH, Cannon CP, Fischer GA, Fung AY, Thompson C, Wybenga D, Braunwald E (1996) Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 335:1342–1349CrossRefPubMed
25.
Zurück zum Zitat Alpert JS, Thygesen K, Antman E, Bassand JP (2000) Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 36:959–969CrossRefPubMed Alpert JS, Thygesen K, Antman E, Bassand JP (2000) Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 36:959–969CrossRefPubMed
26.
Zurück zum Zitat Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408:239–247CrossRefPubMed Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408:239–247CrossRefPubMed
27.
Zurück zum Zitat Chevion M, Berenshtein E, Stadtman ER (2000) Human studies related to protein oxidation: protein carbonyl content as a marker of damage. Free Radic Res 33:99–108 Chevion M, Berenshtein E, Stadtman ER (2000) Human studies related to protein oxidation: protein carbonyl content as a marker of damage. Free Radic Res 33:99–108
28.
Zurück zum Zitat Pantke U, Volk T, Schmutzler M, Kox WJ, Sitte N, Grune T (1999) Oxidized proteins as a marker of oxidative stress during coronary heart surgery. Free Radic Biol Med 27:1080–1086CrossRefPubMed Pantke U, Volk T, Schmutzler M, Kox WJ, Sitte N, Grune T (1999) Oxidized proteins as a marker of oxidative stress during coronary heart surgery. Free Radic Biol Med 27:1080–1086CrossRefPubMed
29.
Zurück zum Zitat Nikolic-Heitzler V, Rabuzin F, Tatzber F, Vrkic N, Bulj N, Borovic S, Wonisch W, Sunko BM, Zarkovic N (2006) Persistent oxidative stress after myocardial infarction treated by percutaneous coronary intervention. J Exp Med 210:247–255 Nikolic-Heitzler V, Rabuzin F, Tatzber F, Vrkic N, Bulj N, Borovic S, Wonisch W, Sunko BM, Zarkovic N (2006) Persistent oxidative stress after myocardial infarction treated by percutaneous coronary intervention. J Exp Med 210:247–255
30.
Zurück zum Zitat Leopold JA, Loscalzo J (2009) Oxidative risk for atherothrombotic cardiovascular disease. Free Radic Biol Med 47:1673–1706CrossRefPubMed Leopold JA, Loscalzo J (2009) Oxidative risk for atherothrombotic cardiovascular disease. Free Radic Biol Med 47:1673–1706CrossRefPubMed
31.
Zurück zum Zitat Nauseef WM, Malech HL (1986) Analysis of the peptide subunits of human neutrophil myeloperoxidase. Blood 67:1504–1507PubMed Nauseef WM, Malech HL (1986) Analysis of the peptide subunits of human neutrophil myeloperoxidase. Blood 67:1504–1507PubMed
32.
Zurück zum Zitat Morrow JD, Minton TA, Badr KF, Roberts LJ (1994) Evidence that the F2-isoprostane, 8-epi-prostaglandin F2 alpha, is formed in vivo. Biochim Biophys Acta 1210:244–248PubMed Morrow JD, Minton TA, Badr KF, Roberts LJ (1994) Evidence that the F2-isoprostane, 8-epi-prostaglandin F2 alpha, is formed in vivo. Biochim Biophys Acta 1210:244–248PubMed
33.
Zurück zum Zitat Walter MF, Jacob RF, Bjork RE, Jeffers B, Buch J, Mizuno Y, Mason RP (2008) Circulating lipid hydroperoxides predict cardiovascular events in patients with stable coronary artery disease: the PREVENT Study. J Am Coll Cardiol 51:1196–1202CrossRefPubMed Walter MF, Jacob RF, Bjork RE, Jeffers B, Buch J, Mizuno Y, Mason RP (2008) Circulating lipid hydroperoxides predict cardiovascular events in patients with stable coronary artery disease: the PREVENT Study. J Am Coll Cardiol 51:1196–1202CrossRefPubMed
34.
Zurück zum Zitat Kumari SS, Menon VP (1987) Changes in concentrations of lipid peroxides and activities of superoxide dismutase and catalase in isoproterenol induced myocardial infarction in rats. Ind J Exp Biol 25:419–423 Kumari SS, Menon VP (1987) Changes in concentrations of lipid peroxides and activities of superoxide dismutase and catalase in isoproterenol induced myocardial infarction in rats. Ind J Exp Biol 25:419–423
35.
Zurück zum Zitat Senthil S, Veerappan RM, Ramakrishna RM, Pugalendi KV (2004) Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction. Clin Chim Acta 348:131–137CrossRefPubMed Senthil S, Veerappan RM, Ramakrishna RM, Pugalendi KV (2004) Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction. Clin Chim Acta 348:131–137CrossRefPubMed
36.
Zurück zum Zitat Chamblee BB, Timm TC, Hunsaker LA, Vander Jagt DL (2000) Relationship of oxidative stress indices to decreased LDL-cholesterol after acute myocardial infarction. Clin Biochem 23:423–426CrossRef Chamblee BB, Timm TC, Hunsaker LA, Vander Jagt DL (2000) Relationship of oxidative stress indices to decreased LDL-cholesterol after acute myocardial infarction. Clin Biochem 23:423–426CrossRef
37.
Zurück zum Zitat Crisby M, Kublickiene K, Henareh L, Agewall S (2009) Circulating levels of autoantibodies to oxidized low-density lipoprotein and C-reactive protein levels correlate with endothelial function in resistance arteries in men with coronary heart disease. Heart Vessels 24:90–95CrossRefPubMed Crisby M, Kublickiene K, Henareh L, Agewall S (2009) Circulating levels of autoantibodies to oxidized low-density lipoprotein and C-reactive protein levels correlate with endothelial function in resistance arteries in men with coronary heart disease. Heart Vessels 24:90–95CrossRefPubMed
38.
Zurück zum Zitat Esterbauer H, Shauer RJ, Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11:28–81CrossRef Esterbauer H, Shauer RJ, Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11:28–81CrossRef
39.
Zurück zum Zitat Paradies G, Petrosillo G, Pistolese M, Di Venosa N, Serena D, Ruggiero F (1999) Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from heart subjected to ischemia and reperfusion. Free Radic Biol Med 27:42–50CrossRefPubMed Paradies G, Petrosillo G, Pistolese M, Di Venosa N, Serena D, Ruggiero F (1999) Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from heart subjected to ischemia and reperfusion. Free Radic Biol Med 27:42–50CrossRefPubMed
40.
Zurück zum Zitat Akila BD, Vishwanath P, D’souza V (2007) Oxidative injury and antioxidants in coronary artery bypass graft surgery: Off-pump CABG significantly reduces oxidative stress. Clin Chim Acta 375:147–152CrossRefPubMed Akila BD, Vishwanath P, D’souza V (2007) Oxidative injury and antioxidants in coronary artery bypass graft surgery: Off-pump CABG significantly reduces oxidative stress. Clin Chim Acta 375:147–152CrossRefPubMed
41.
Zurück zum Zitat Weinbrenner T, Cladellas M, Covas MI, Fitó M, Tomás M, Sentí M, Bruguera J, Marrugat J (2003) High oxidative stress in patients with stable coronary heart disease. Atherosclerosis 168:99–106CrossRefPubMed Weinbrenner T, Cladellas M, Covas MI, Fitó M, Tomás M, Sentí M, Bruguera J, Marrugat J (2003) High oxidative stress in patients with stable coronary heart disease. Atherosclerosis 168:99–106CrossRefPubMed
42.
Zurück zum Zitat Kesavulu MM, Rao BK, Giri R, Vijaya J, Subramanyam G, Apparao C (2001) Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease. Diabetes Res Clin Pr 53:33–39CrossRef Kesavulu MM, Rao BK, Giri R, Vijaya J, Subramanyam G, Apparao C (2001) Lipid peroxidation and antioxidant enzyme status in Type 2 diabetics with coronary heart disease. Diabetes Res Clin Pr 53:33–39CrossRef
43.
Zurück zum Zitat Pandey NR, Kaur G, Chandra M, Sanwal GG, Misra MK (2000) Enzymatic oxidant and antioxidants of human blood platelets in unstable angina and myocardial infarction. Int J Cardiol 76:33–38CrossRefPubMed Pandey NR, Kaur G, Chandra M, Sanwal GG, Misra MK (2000) Enzymatic oxidant and antioxidants of human blood platelets in unstable angina and myocardial infarction. Int J Cardiol 76:33–38CrossRefPubMed
44.
Zurück zum Zitat Zhou X, Zhai X, Ashraf M (1996) Direct evidence that initial oxidative stress triggered by preconditioning contributes to second window of protection by endogenous antioxidant enzyme in myocytes. Circulation 93:1177–1184PubMed Zhou X, Zhai X, Ashraf M (1996) Direct evidence that initial oxidative stress triggered by preconditioning contributes to second window of protection by endogenous antioxidant enzyme in myocytes. Circulation 93:1177–1184PubMed
45.
Zurück zum Zitat Singh RB, Pella D, Neki NS, Chandel JP, Rastogi S, Mori H, Otsuka K, Gupta P (2004) Mechanisms of acute myocardial infarction study (MAMIS). Biomed Pharmacother 58:111–115CrossRef Singh RB, Pella D, Neki NS, Chandel JP, Rastogi S, Mori H, Otsuka K, Gupta P (2004) Mechanisms of acute myocardial infarction study (MAMIS). Biomed Pharmacother 58:111–115CrossRef
46.
Zurück zum Zitat Janero DR, Burghardt B (1989) Cardiac membrane vitamin E and malondialdehyde levels in heart muscle of normotensive and spontaneously hypertensive rats. Lipids 24:33–38CrossRefPubMed Janero DR, Burghardt B (1989) Cardiac membrane vitamin E and malondialdehyde levels in heart muscle of normotensive and spontaneously hypertensive rats. Lipids 24:33–38CrossRefPubMed
47.
Zurück zum Zitat Yamazaki K, Miwa S, Toyokuni S, Nemoto S, Oriyanhan W, Takaba K, Saji Y, Marui A, Nishina T, Ikeda T, Komeda M (2009) Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart. Heart Vessels 24:228–235CrossRefPubMed Yamazaki K, Miwa S, Toyokuni S, Nemoto S, Oriyanhan W, Takaba K, Saji Y, Marui A, Nishina T, Ikeda T, Komeda M (2009) Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart. Heart Vessels 24:228–235CrossRefPubMed
48.
Zurück zum Zitat Yamazaki KG, Romero-Perez D, Barraza-Hidalgo M, Cruz M, Rivas M, Cortez-Gomez B, Ceballos G, Villarreal F (2008) Short and long term effects of (−)-epicatechin on myocardial ischemia reperfusion injury. Am J Physiol Heart Circ Physiol 295:H761–H767CrossRefPubMed Yamazaki KG, Romero-Perez D, Barraza-Hidalgo M, Cruz M, Rivas M, Cortez-Gomez B, Ceballos G, Villarreal F (2008) Short and long term effects of (−)-epicatechin on myocardial ischemia reperfusion injury. Am J Physiol Heart Circ Physiol 295:H761–H767CrossRefPubMed
49.
Zurück zum Zitat Ikizler M, Erkasap N, Dernek S, Kural T, Kaygisiz Z (2007) Dietary polyphenol quercetin protects rat hearts during reperfusion: enhanced antioxidant capacity with chronic treatment. Anadolu Kardiyol Derg 7:404–410PubMed Ikizler M, Erkasap N, Dernek S, Kural T, Kaygisiz Z (2007) Dietary polyphenol quercetin protects rat hearts during reperfusion: enhanced antioxidant capacity with chronic treatment. Anadolu Kardiyol Derg 7:404–410PubMed
50.
Zurück zum Zitat Napoli C, Balestrieri ML, Lerman VSLO, Crimi E, Schiano GRC, D’Armiento LSFP (2008) Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis. Heart Vessels 23:124–133CrossRefPubMed Napoli C, Balestrieri ML, Lerman VSLO, Crimi E, Schiano GRC, D’Armiento LSFP (2008) Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis. Heart Vessels 23:124–133CrossRefPubMed
51.
Zurück zum Zitat Bertelli AA, Das KD (2009) Grapes, wines, resveratrol and heart health. J Cardiovasc Pharmacol 54:468–476 Bertelli AA, Das KD (2009) Grapes, wines, resveratrol and heart health. J Cardiovasc Pharmacol 54:468–476
52.
Zurück zum Zitat Fearon IM, Faux SP (2009) Oxidative stress and cardiovascular disease: novel tools give (free) radical insight. J Mol Cell Cardiol 47:372–381CrossRefPubMed Fearon IM, Faux SP (2009) Oxidative stress and cardiovascular disease: novel tools give (free) radical insight. J Mol Cell Cardiol 47:372–381CrossRefPubMed
53.
Zurück zum Zitat Pereillo JM, Maftouh M, Andrieu A, Uzabiaga MF, Fedeli O, Savi P, Pascal M, Herbert JM, Maffrand JP, Picard C (2002) Structure and stereochemistry of the active metabolite of clopidogrel. Drug Metab Dispos 30:1288–1295CrossRefPubMed Pereillo JM, Maftouh M, Andrieu A, Uzabiaga MF, Fedeli O, Savi P, Pascal M, Herbert JM, Maffrand JP, Picard C (2002) Structure and stereochemistry of the active metabolite of clopidogrel. Drug Metab Dispos 30:1288–1295CrossRefPubMed
Metadaten
Titel
Oxidative stress versus antioxidant defenses in patients with acute myocardial infarction
verfasst von
Margarete Dulce Bagatini
Caroline Curry Martins
Vanessa Battisti
Diogo Gasparetto
Cintia Saydelles da Rosa
Roselia Maria Spanevello
Mushtaq Ahmed
Roberta Schmatz
Maria Rosa Chitolina Schetinger
Vera Maria Morsch
Publikationsdatum
01.01.2011
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 1/2011
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-010-0029-9

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