Skip to main content
Erschienen in: Cancer and Metastasis Reviews 2-3/2018

22.06.2018

Oxygenated lipid signaling in tumor-associated macrophages—focus on colon cancer

verfasst von: Jennifer K. Colby, Jonathan Jaoude, Fuyao Liu, Imad Shureiqi

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 2-3/2018

Einloggen, um Zugang zu erhalten

Abstract

Polyunsaturated fatty acids (PUFAs) are enzymatically converted to a variety of bioactive products through insertion of molecular oxygen. PUFA-derived mediators can have either inflammatory or anti-inflammatory/pro-resolving properties, depending upon their specific structures. The relative harm or benefit of these mediators can also be tissue and context dependent. These mediators play important roles in maintaining homeostasis and their dysregulation is involved in pathogenesis of cancers, especially those associated with chronic inflammation. There is a well-established link between colorectal cancer (CRC) and chronic inflammation. The colon harbors a large population of immune cells, which must be tightly regulated in order to maintain the balance between pathogenic and commensal microbes in the gut. Macrophages are key to the process of distinguishing between potentially harmful antigens/microbes and benign or beneficial signals. Macrophages are often associated with tumors (tumor-associated macrophages (TAMs), including CRC. There is some debate as to the prognostic significance of these TAMs in CRC, with some work suggesting a beneficial impact. The purpose of this review is to give an overview of what is currently known regarding PUFA-derived mediator signaling in tumor-associated macrophages in CRC.
Literatur
2.
Zurück zum Zitat Fitzmaurice, C., Allen, C., Barber, R. M., Barregard, L., Bhutta, Z. A., Brenner, H., et al. (2017). Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the Global Burden of Disease Study. JAMA Oncology, 3(4), 524–548. https://doi.org/10.1001/jamaoncol.2016.5688.PubMedCrossRef Fitzmaurice, C., Allen, C., Barber, R. M., Barregard, L., Bhutta, Z. A., Brenner, H., et al. (2017). Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the Global Burden of Disease Study. JAMA Oncology, 3(4), 524–548. https://​doi.​org/​10.​1001/​jamaoncol.​2016.​5688.PubMedCrossRef
31.
Zurück zum Zitat Freire-de-Lima, C. G., Xiao, Y., Gardai, S. J., Bratton, D. L., Schiemann, W. P., & Henson, P. M. (2006). Apoptotic cells, through transforming growth factor-β, coordinately induce anti-inflammatory and suppress proinflammatory eicosanoid and no synthesis in murine macrophages. Journal of Biological Chemistry, 281(50), 38376–38384. https://doi.org/10.1074/jbc.M605146200.PubMedCrossRef Freire-de-Lima, C. G., Xiao, Y., Gardai, S. J., Bratton, D. L., Schiemann, W. P., & Henson, P. M. (2006). Apoptotic cells, through transforming growth factor-β, coordinately induce anti-inflammatory and suppress proinflammatory eicosanoid and no synthesis in murine macrophages. Journal of Biological Chemistry, 281(50), 38376–38384. https://​doi.​org/​10.​1074/​jbc.​M605146200.PubMedCrossRef
37.
Zurück zum Zitat Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000). M-1/M-2 macrophages and the Th1/Th2 paradigm. Journal of Immunology (Baltimore, Md.: 1950), 164(12), 6166–6173.CrossRef Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000). M-1/M-2 macrophages and the Th1/Th2 paradigm. Journal of Immunology (Baltimore, Md.: 1950), 164(12), 6166–6173.CrossRef
57.
Zurück zum Zitat Evans, R., & Alexander, P. (1970). Cooperation of immune lymphoid cells with macrophages in tumour immunity. Nature, 228(5272), 620–622.PubMedCrossRef Evans, R., & Alexander, P. (1970). Cooperation of immune lymphoid cells with macrophages in tumour immunity. Nature, 228(5272), 620–622.PubMedCrossRef
59.
64.
Zurück zum Zitat Iglesia, M. D., Parker, J. S., Hoadley, K. A., Serody, J. S., Perou, C. M., & Vincent, B. G. (2016). Genomic analysis of immune cell infiltrates across 11 tumor types. Journal of the National Cancer Institute, 108(11). https://doi.org/10.1093/jnci/djw144. Iglesia, M. D., Parker, J. S., Hoadley, K. A., Serody, J. S., Perou, C. M., & Vincent, B. G. (2016). Genomic analysis of immune cell infiltrates across 11 tumor types. Journal of the National Cancer Institute, 108(11). https://​doi.​org/​10.​1093/​jnci/​djw144.
66.
68.
Zurück zum Zitat Funada, Y., Noguchi, T., Kikuchi, R., Takeno, S., Uchida, Y., & Gabbert, H. E. (2003). Prognostic significance of CD8+ T cell and macrophage peritumoral infiltration in colorectal cancer. Oncology Reports, 10(2), 309–313.PubMed Funada, Y., Noguchi, T., Kikuchi, R., Takeno, S., Uchida, Y., & Gabbert, H. E. (2003). Prognostic significance of CD8+ T cell and macrophage peritumoral infiltration in colorectal cancer. Oncology Reports, 10(2), 309–313.PubMed
82.
Zurück zum Zitat Pawlosky, R. J., Hibbeln, J. R., Novotny, J. A., & Salem, N. (2001). Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. Journal of Lipid Research, 42(8), 1257–1265.PubMed Pawlosky, R. J., Hibbeln, J. R., Novotny, J. A., & Salem, N. (2001). Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. Journal of Lipid Research, 42(8), 1257–1265.PubMed
95.
Zurück zum Zitat Oliw, E. (1994). Oxygenation of polyunsaturated fatty acids by cytochrome p450 monooxygenases. Progress in Lipid Research, 33(3), 329–354.PubMedCrossRef Oliw, E. (1994). Oxygenation of polyunsaturated fatty acids by cytochrome p450 monooxygenases. Progress in Lipid Research, 33(3), 329–354.PubMedCrossRef
102.
Zurück zum Zitat Marnett, L. J., Rowlinson, S. W., Goodwin, D. C., Kalgutkar, A. S., & Lanzo, C. A. (1999). Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition. The Journal of Biological Chemistry, 274(33), 22903–22906.PubMed Marnett, L. J., Rowlinson, S. W., Goodwin, D. C., Kalgutkar, A. S., & Lanzo, C. A. (1999). Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition. The Journal of Biological Chemistry, 274(33), 22903–22906.PubMed
103.
114.
Zurück zum Zitat de la Rosa, X., Norris, P. C., Chiang, N., Rodriguez, A. R., Spur, B. W., & Serhan, C. N. (2018). Identification and complete stereochemical assignments of the new resolvin conjugates in tissue regeneration in human tissues that stimulate proresolving phagocyte functions and tissue regeneration. The American Journal of Pathology, 188(4), 950–966. https://doi.org/10.1016/j.ajpath.2018.01.004.PubMedCrossRef de la Rosa, X., Norris, P. C., Chiang, N., Rodriguez, A. R., Spur, B. W., & Serhan, C. N. (2018). Identification and complete stereochemical assignments of the new resolvin conjugates in tissue regeneration in human tissues that stimulate proresolving phagocyte functions and tissue regeneration. The American Journal of Pathology, 188(4), 950–966. https://​doi.​org/​10.​1016/​j.​ajpath.​2018.​01.​004.PubMedCrossRef
118.
Zurück zum Zitat Lecomte, M., Laneuville, O., Ji, C., DeWitt, D. L., & Smith, W. L. (1994). Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. The Journal of Biological Chemistry, 269(18), 13207–13215.PubMed Lecomte, M., Laneuville, O., Ji, C., DeWitt, D. L., & Smith, W. L. (1994). Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. The Journal of Biological Chemistry, 269(18), 13207–13215.PubMed
129.
132.
142.
144.
157.
158.
Zurück zum Zitat Silverman, A. L., Bronstein, J. C., Krymgold, S., Kahlon, D., & Bull, A. W. (1996). Decreased levels of 13-hydroxyoctadecadienoic acid (13-HODE) dehydrogenase in neoplastic tissue of human colon biopsies. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive. Oncology, 5(1), 53–56. Silverman, A. L., Bronstein, J. C., Krymgold, S., Kahlon, D., & Bull, A. W. (1996). Decreased levels of 13-hydroxyoctadecadienoic acid (13-HODE) dehydrogenase in neoplastic tissue of human colon biopsies. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive. Oncology, 5(1), 53–56.
159.
Zurück zum Zitat Bull, A. W., Branting, C., Bronstein, J. C., Blackburn, M. L., & Rafter, J. (1993). Increases in 13-hydroxyoctadecadienoic acid dehydrogenase activity during differentiation of cultured cells. Carcinogenesis, 14(11), 2239–2243.PubMedCrossRef Bull, A. W., Branting, C., Bronstein, J. C., Blackburn, M. L., & Rafter, J. (1993). Increases in 13-hydroxyoctadecadienoic acid dehydrogenase activity during differentiation of cultured cells. Carcinogenesis, 14(11), 2239–2243.PubMedCrossRef
164.
Zurück zum Zitat Qian, Z., Wu, Z., Huang, L., Qiu, H., Wang, L., Li, L., et al. (2015). Mulberry fruit prevents LPS-induced NF-kappaB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice. Scientific Reports, 5. https://doi.org/10.1038/srep17348. Qian, Z., Wu, Z., Huang, L., Qiu, H., Wang, L., Li, L., et al. (2015). Mulberry fruit prevents LPS-induced NF-kappaB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice. Scientific Reports, 5. https://​doi.​org/​10.​1038/​srep17348.
165.
Zurück zum Zitat Meterissian, S. H., Forse, R. A., Steele, G. D., & Thomas, P. (1995). Effect of membrane free fatty acid alterations on the adhesion of human colorectal carcinoma cells to liver macrophages and extracellular matrix proteins. Cancer Letters, 89(2), 145–152.PubMedCrossRef Meterissian, S. H., Forse, R. A., Steele, G. D., & Thomas, P. (1995). Effect of membrane free fatty acid alterations on the adhesion of human colorectal carcinoma cells to liver macrophages and extracellular matrix proteins. Cancer Letters, 89(2), 145–152.PubMedCrossRef
173.
Zurück zum Zitat Burke, L., Butler, C. T., Murphy, A., Moran, B., Gallagher, W. M., O'Sullivan, J., et al. (2016). Evaluation of cysteinyl leukotriene signaling as a therapeutic target for colorectal cancer. Frontiers in Cell and Development Biology, 4(103). https://doi.org/10.3389/fcell.2016.00103. Burke, L., Butler, C. T., Murphy, A., Moran, B., Gallagher, W. M., O'Sullivan, J., et al. (2016). Evaluation of cysteinyl leukotriene signaling as a therapeutic target for colorectal cancer. Frontiers in Cell and Development Biology, 4(103). https://​doi.​org/​10.​3389/​fcell.​2016.​00103.
181.
Zurück zum Zitat Kambayashi, T., Alexander, H. R., Fong, M., & Strassmann, G. (1995). Potential involvement of IL-10 in suppressing tumor-associated macrophages. Colon-26-derived prostaglandin E2 inhibits TNF-alpha release via a mechanism involving IL-10. Journal of Immunology (Baltimore, Md.: 1950), 154(7), 3383–3390. Kambayashi, T., Alexander, H. R., Fong, M., & Strassmann, G. (1995). Potential involvement of IL-10 in suppressing tumor-associated macrophages. Colon-26-derived prostaglandin E2 inhibits TNF-alpha release via a mechanism involving IL-10. Journal of Immunology (Baltimore, Md.: 1950), 154(7), 3383–3390.
184.
186.
Zurück zum Zitat Mutoh, M., Watanabe, K., Kitamura, T., Shoji, Y., Takahashi, M., Kawamori, T., et al. (2002). Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. Cancer Research, 62(1), 28–32.PubMed Mutoh, M., Watanabe, K., Kitamura, T., Shoji, Y., Takahashi, M., Kawamori, T., et al. (2002). Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. Cancer Research, 62(1), 28–32.PubMed
187.
Zurück zum Zitat Prima, V., Kaliberova, L. N., Kaliberov, S., Curiel, D. T., & Kusmartsev, S. (2017). COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells. Proceedings of the National Academy of Sciences, 114(5), 1117–1122. https://doi.org/10.1073/pnas.1612920114.CrossRef Prima, V., Kaliberova, L. N., Kaliberov, S., Curiel, D. T., & Kusmartsev, S. (2017). COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells. Proceedings of the National Academy of Sciences, 114(5), 1117–1122. https://​doi.​org/​10.​1073/​pnas.​1612920114.CrossRef
189.
Zurück zum Zitat Heusinkveld, M., de van Steenwijk, P. J., Goedemans, R., Ramwadhdoebe, T. H., Gorter, A., Welters, M. J. P., et al. (2011). M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. The Journal of Immunology, 187(3), 1157–1165. https://doi.org/10.4049/jimmunol.1100889.PubMedCrossRef Heusinkveld, M., de van Steenwijk, P. J., Goedemans, R., Ramwadhdoebe, T. H., Gorter, A., Welters, M. J. P., et al. (2011). M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. The Journal of Immunology, 187(3), 1157–1165. https://​doi.​org/​10.​4049/​jimmunol.​1100889.PubMedCrossRef
192.
Zurück zum Zitat Eruslanov, E., Daurkin, I., Ortiz, J., Vieweg, J., & Kusmartsev, S. (2010). Pivotal advance: tumormediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE(2) catabolism in myeloid cells. Journal of Leukocyte Biology, 88(5), 839–848. https://doi.org/10.1189/jlb.1209821.PubMedCrossRef Eruslanov, E., Daurkin, I., Ortiz, J., Vieweg, J., & Kusmartsev, S. (2010). Pivotal advance: tumormediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE(2) catabolism in myeloid cells. Journal of Leukocyte Biology, 88(5), 839–848. https://​doi.​org/​10.​1189/​jlb.​1209821.PubMedCrossRef
193.
Zurück zum Zitat Eruslanov, E., Kaliberov, S., Daurkin, I., Kaliberova, L., Buchsbaum, D., Vieweg, J., et al. (2009). Altered expression of 15-hydroxyprostaglandin dehydrogenase in tumor-infiltrated CD11b myeloid cells: a mechanism for immune evasion in cancer. Journal of Immunology, 182(12), 7548–7557. https://doi.org/10.4049/jimmunol.0802358.CrossRef Eruslanov, E., Kaliberov, S., Daurkin, I., Kaliberova, L., Buchsbaum, D., Vieweg, J., et al. (2009). Altered expression of 15-hydroxyprostaglandin dehydrogenase in tumor-infiltrated CD11b myeloid cells: a mechanism for immune evasion in cancer. Journal of Immunology, 182(12), 7548–7557. https://​doi.​org/​10.​4049/​jimmunol.​0802358.CrossRef
195.
Zurück zum Zitat Kanaoka, Y., & Urade, Y. (2003). Hematopoietic prostaglandin D synthase. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 69(2-3), 163–167.PubMedCrossRef Kanaoka, Y., & Urade, Y. (2003). Hematopoietic prostaglandin D synthase. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 69(2-3), 163–167.PubMedCrossRef
196.
Zurück zum Zitat Nugteren, D. H., & Hazelhof, E. (1973). Isolation and properties of intermediates in prostaglandin biosynthesis. Biochimica et Biophysica Acta, 326(3), 448–461.PubMedCrossRef Nugteren, D. H., & Hazelhof, E. (1973). Isolation and properties of intermediates in prostaglandin biosynthesis. Biochimica et Biophysica Acta, 326(3), 448–461.PubMedCrossRef
201.
Zurück zum Zitat Straus, D. S., & Glass, C. K. (2001). Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Medicinal Research Reviews, 21(3), 185–210.PubMedCrossRef Straus, D. S., & Glass, C. K. (2001). Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Medicinal Research Reviews, 21(3), 185–210.PubMedCrossRef
202.
Zurück zum Zitat Drew, P. D., & Chavis, J. A. (2001). The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells. Journal of Neuroimmunology, 115(1-2), 28–35.PubMedCrossRef Drew, P. D., & Chavis, J. A. (2001). The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells. Journal of Neuroimmunology, 115(1-2), 28–35.PubMedCrossRef
204.
206.
Zurück zum Zitat Kansal, S., Vaiphei, K., & Agnihotri, N. (2014). Alterations in lipid mediated signaling and Wnt/ beta -catenin signaling in DMH induced colon cancer on supplementation of fish oil. BioMed Research International. https://doi.org/10.1155/2014/832025. Kansal, S., Vaiphei, K., & Agnihotri, N. (2014). Alterations in lipid mediated signaling and Wnt/ beta -catenin signaling in DMH induced colon cancer on supplementation of fish oil. BioMed Research International. https://​doi.​org/​10.​1155/​2014/​832025.
208.
Zurück zum Zitat Hyun, J., Romero, L., Riveron, R., Flores, C., Kanagavelu, S., Chung, K. D., et al. (2015). Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. Journal of Innate Immunity, 7(1), 87–101. https://doi.org/10.1159/000365417.PubMedCrossRef Hyun, J., Romero, L., Riveron, R., Flores, C., Kanagavelu, S., Chung, K. D., et al. (2015). Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. Journal of Innate Immunity, 7(1), 87–101. https://​doi.​org/​10.​1159/​000365417.PubMedCrossRef
212.
Zurück zum Zitat Sasaki, Y., Kamiyama, S., Kamiyama, A., Matsumoto, K., Akatsu, M., Nakatani, Y., et al. (2015). Genetic-deletion of cyclooxygenase-2 downstream prostacyclin synthase suppresses inflammatory reactions but facilitates carcinogenesis, unlike deletion of microsomal prostaglandin E Synthase-1. Scientific Reports, 5(1). https://doi.org/10.1038/srep17376. Sasaki, Y., Kamiyama, S., Kamiyama, A., Matsumoto, K., Akatsu, M., Nakatani, Y., et al. (2015). Genetic-deletion of cyclooxygenase-2 downstream prostacyclin synthase suppresses inflammatory reactions but facilitates carcinogenesis, unlike deletion of microsomal prostaglandin E Synthase-1. Scientific Reports, 5(1). https://​doi.​org/​10.​1038/​srep17376.
215.
Zurück zum Zitat Nemenoff, R., Meyer, A. M., Hudish, T. M., Mozer, A. B., Snee, A., Narumiya, S., et al. (2008). Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator-activated receptor gamma. Cancer Prevention Research (Philadelphia, Pa.), 1(5), 349–356. https://doi.org/10.1158/1940-6207.CAPR-08-0145.CrossRef Nemenoff, R., Meyer, A. M., Hudish, T. M., Mozer, A. B., Snee, A., Narumiya, S., et al. (2008). Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator-activated receptor gamma. Cancer Prevention Research (Philadelphia, Pa.), 1(5), 349–356. https://​doi.​org/​10.​1158/​1940-6207.​CAPR-08-0145.CrossRef
219.
Zurück zum Zitat Hamberg, M., Svensson, J., & Samuelsson, B. (1974). Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proceedings of the National Academy of Sciences of the United States of America, 71(10), 3824–3828.PubMedPubMedCentralCrossRef Hamberg, M., Svensson, J., & Samuelsson, B. (1974). Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proceedings of the National Academy of Sciences of the United States of America, 71(10), 3824–3828.PubMedPubMedCentralCrossRef
222.
Zurück zum Zitat Li, X., & Tai, H. H. (2013). Activation of thromboxane A2 receptor (TP) increases the expression of monocyte chemoattractant protein -1 (MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) and recruits macrophages to promote invasion of lung cancer cells. PLoS One, 8(1). doi:https://doi.org/10.1371/journal.pone.0054073 Li, X., & Tai, H. H. (2013). Activation of thromboxane A2 receptor (TP) increases the expression of monocyte chemoattractant protein -1 (MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) and recruits macrophages to promote invasion of lung cancer cells. PLoS One, 8(1). doi:https://​doi.​org/​10.​1371/​journal.​pone.​0054073
228.
Zurück zum Zitat Arita, M., Yoshida, M., Hong, S., Tjonahen, E., Glickman, J. N., Petasis, N. A., et al. (2005). Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proceedings of the National Academy of Sciences of the United States of America, 102(21), 7671–7676. https://doi.org/10.1073/pnas.0409271102.PubMedPubMedCentralCrossRef Arita, M., Yoshida, M., Hong, S., Tjonahen, E., Glickman, J. N., Petasis, N. A., et al. (2005). Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proceedings of the National Academy of Sciences of the United States of America, 102(21), 7671–7676. https://​doi.​org/​10.​1073/​pnas.​0409271102.PubMedPubMedCentralCrossRef
229.
Zurück zum Zitat Ihara, A., Wada, K., Yoneda, M., Fujisawa, N., Takahashi, H., & Nakajima, A. (2007). Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer. Journal of Pharmacological Sciences, 103(1), 24–32.PubMedCrossRef Ihara, A., Wada, K., Yoneda, M., Fujisawa, N., Takahashi, H., & Nakajima, A. (2007). Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer. Journal of Pharmacological Sciences, 103(1), 24–32.PubMedCrossRef
230.
Zurück zum Zitat Gounaris, E., Heiferman, M. J., Heiferman, J. R., Shrivastav, M., Vitello, D., Blatner, N. R., et al (2015). Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One, 10(3). https://doi.org/10.1371/journal.pone.0121402. Gounaris, E., Heiferman, M. J., Heiferman, J. R., Shrivastav, M., Vitello, D., Blatner, N. R., et al (2015). Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One, 10(3). https://​doi.​org/​10.​1371/​journal.​pone.​0121402.
232.
Zurück zum Zitat Nielsen, O. H., Verspaget, H. W., & Elmgreen, J. (1988). Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Alimentary Pharmacology & Therapeutics, 2(3), 203–211.CrossRef Nielsen, O. H., Verspaget, H. W., & Elmgreen, J. (1988). Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Alimentary Pharmacology & Therapeutics, 2(3), 203–211.CrossRef
240.
243.
250.
Zurück zum Zitat Kim, J. H., Tagari, P., Griffiths, A. M., Ford-Hutchinson, A., Smith, C., & Sherman, P. M. (1995). Levels of peptidoleukotriene E4 are elevated in active Crohn's disease. Journal of Pediatric Gastroenterology and Nutrition, 20(4), 403–407.PubMedCrossRef Kim, J. H., Tagari, P., Griffiths, A. M., Ford-Hutchinson, A., Smith, C., & Sherman, P. M. (1995). Levels of peptidoleukotriene E4 are elevated in active Crohn's disease. Journal of Pediatric Gastroenterology and Nutrition, 20(4), 403–407.PubMedCrossRef
251.
Zurück zum Zitat Sharon, P., & Stenson, W. F. (1984). Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology, 86(3), 453–460.PubMed Sharon, P., & Stenson, W. F. (1984). Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology, 86(3), 453–460.PubMed
257.
Zurück zum Zitat de Carvalho, D. D., Sadok, A., Bourgarel-Rey, V., Gattacceca, F., Penel, C., Lehmann, M., et al. (2008). Nox1 downstream of 12-lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells. International Journal of Cancer, 122(8), 1757–1764. https://doi.org/10.1002/ijc.23300.PubMedCrossRef de Carvalho, D. D., Sadok, A., Bourgarel-Rey, V., Gattacceca, F., Penel, C., Lehmann, M., et al. (2008). Nox1 downstream of 12-lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells. International Journal of Cancer, 122(8), 1757–1764. https://​doi.​org/​10.​1002/​ijc.​23300.PubMedCrossRef
259.
Zurück zum Zitat Rabinovitch, H., Durand, J., Rigaud, M., Mendy, F., & Breton, J. C. (1981). Transformation of arachidonic acid into monohydroxy-eicosatetraenoic acids by mouse peritoneal macrophages. Lipids, 16(7), 518–524.PubMedCrossRef Rabinovitch, H., Durand, J., Rigaud, M., Mendy, F., & Breton, J. C. (1981). Transformation of arachidonic acid into monohydroxy-eicosatetraenoic acids by mouse peritoneal macrophages. Lipids, 16(7), 518–524.PubMedCrossRef
260.
Zurück zum Zitat Serhan, C. N., Levy, B. D., Clish, C. B., Gronert, K., & Chiang, N. (2000). Lipoxins, aspirin-triggered 15-epilipoxin stable analogs and their receptors in anti-inflammation: a window for therapeutic opportunity. Ernst Schering Research Foundation Workshop, 31, 143–185. Serhan, C. N., Levy, B. D., Clish, C. B., Gronert, K., & Chiang, N. (2000). Lipoxins, aspirin-triggered 15-epilipoxin stable analogs and their receptors in anti-inflammation: a window for therapeutic opportunity. Ernst Schering Research Foundation Workshop, 31, 143–185.
262.
Zurück zum Zitat Janakiram, N. B., & Rao, C. V. (2009). Role of lipoxins and resolvins as anti-inflammatory and proresolving mediators in colon cancer. Current Molecular Medicine, 9(5), 565–579.PubMedCrossRef Janakiram, N. B., & Rao, C. V. (2009). Role of lipoxins and resolvins as anti-inflammatory and proresolving mediators in colon cancer. Current Molecular Medicine, 9(5), 565–579.PubMedCrossRef
265.
Zurück zum Zitat Kure, I., Nishiumi, S., Nishitani, Y., Tanoue, T., Ishida, T., Mizuno, M., et al. (2010). Lipoxin A(4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor-kappaB activation. The Journal of Pharmacology and Experimental Therapeutics, 332(2), 541–548. https://doi.org/10.1124/jpet.109.159046.PubMedCrossRef Kure, I., Nishiumi, S., Nishitani, Y., Tanoue, T., Ishida, T., Mizuno, M., et al. (2010). Lipoxin A(4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor-kappaB activation. The Journal of Pharmacology and Experimental Therapeutics, 332(2), 541–548. https://​doi.​org/​10.​1124/​jpet.​109.​159046.PubMedCrossRef
267.
Zurück zum Zitat Simões, R. L., De-Brito, N. M., Cunha-Costa, H., Morandi, V., Fierro, I. M., Roitt, I. M., et al. (2016). Lipoxin A4 selectively programs the profile of m2 tumor-associated macrophages which favour control of tumor progression. International Journal of Cancer, 140(2), 346–357. https://doi.org/10.1002/ijc.30424.PubMedCrossRef Simões, R. L., De-Brito, N. M., Cunha-Costa, H., Morandi, V., Fierro, I. M., Roitt, I. M., et al. (2016). Lipoxin A4 selectively programs the profile of m2 tumor-associated macrophages which favour control of tumor progression. International Journal of Cancer, 140(2), 346–357. https://​doi.​org/​10.​1002/​ijc.​30424.PubMedCrossRef
269.
Zurück zum Zitat Prieto, P., Cuenca, J., Través, P. G., Fernández-Velasco, M., Martín-Sanz, P., & Boscá, L. (2010). Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways. Cell Death and Differentiation, 17(7), 1179–1188. https://doi.org/10.1038/cdd.2009.220.PubMedCrossRef Prieto, P., Cuenca, J., Través, P. G., Fernández-Velasco, M., Martín-Sanz, P., & Boscá, L. (2010). Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways. Cell Death and Differentiation, 17(7), 1179–1188. https://​doi.​org/​10.​1038/​cdd.​2009.​220.PubMedCrossRef
272.
Zurück zum Zitat Zhang, W., Li, H., Dong, H., Liao, J., Hammock, B. D., & Yang, G. Y. (2013). Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Anticancer Research, 33(12), 5261–5271.PubMedPubMedCentral Zhang, W., Li, H., Dong, H., Liao, J., Hammock, B. D., & Yang, G. Y. (2013). Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Anticancer Research, 33(12), 5261–5271.PubMedPubMedCentral
274.
280.
Zurück zum Zitat Siscovick, D. S., Barringer, T. A., Fretts, A. M., Wu, J. H. Y., Lichtenstein, A. H., Costello, R. B., et al. (2017). Omega-3 polyunsaturated fatty acid (fish oil) supplementation and the prevention of clinical cardiovascular disease. Circulation, 135(15). https://doi.org/10.1161/CIR.0000000000000482. Siscovick, D. S., Barringer, T. A., Fretts, A. M., Wu, J. H. Y., Lichtenstein, A. H., Costello, R. B., et al. (2017). Omega-3 polyunsaturated fatty acid (fish oil) supplementation and the prevention of clinical cardiovascular disease. Circulation, 135(15). https://​doi.​org/​10.​1161/​CIR.​0000000000000482​.
295.
Zurück zum Zitat Terano, T., Salmon, J. A., & Moncada, S. (1984). Biosynthesis and biological activity of leukotriene B5. Prostaglandins, 27(2), 217–232.PubMedCrossRef Terano, T., Salmon, J. A., & Moncada, S. (1984). Biosynthesis and biological activity of leukotriene B5. Prostaglandins, 27(2), 217–232.PubMedCrossRef
296.
Zurück zum Zitat Bagga, D., Wang, L., Farias-Eisner, R., Glaspy, J. A., & Reddy, S. T. (2003). Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proceedings of the National Academy of Sciences, 100(4), 1751–1756. https://doi.org/10.1073/pnas.0334211100.CrossRef Bagga, D., Wang, L., Farias-Eisner, R., Glaspy, J. A., & Reddy, S. T. (2003). Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion. Proceedings of the National Academy of Sciences, 100(4), 1751–1756. https://​doi.​org/​10.​1073/​pnas.​0334211100.CrossRef
298.
Zurück zum Zitat Sorensen, L. S., Thorlacius-Ussing, O., Rasmussen, H. H., Lundbye-Christensen, S., Calder, P. C., Lindorff-Larsen, K., et al. (2014). Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B4 and leukotriene B5 production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial. Nutrients, 6(10), 4043–4057. https://doi.org/10.3390/nu6104043.PubMedPubMedCentralCrossRef Sorensen, L. S., Thorlacius-Ussing, O., Rasmussen, H. H., Lundbye-Christensen, S., Calder, P. C., Lindorff-Larsen, K., et al. (2014). Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B4 and leukotriene B5 production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial. Nutrients, 6(10), 4043–4057. https://​doi.​org/​10.​3390/​nu6104043.PubMedPubMedCentralCrossRef
304.
Zurück zum Zitat Spanbroek, R., Hildner, M., Köhler, A., Müller, A., Zintl, F., Kühn, H., et al (2001). IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression. Proceedings of the National Academy of Sciences, 98(9), 5152–5157. https://doi.org/10.1073/pnas.091076998.CrossRef Spanbroek, R., Hildner, M., Köhler, A., Müller, A., Zintl, F., Kühn, H., et al (2001). IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression. Proceedings of the National Academy of Sciences, 98(9), 5152–5157. https://​doi.​org/​10.​1073/​pnas.​091076998.CrossRef
310.
312.
Zurück zum Zitat Bento, A. F., Claudino, R. F., Dutra, R. C., Marcon, R., & Calixto, J. B. B. (2011). Omega-3 fatty acidderived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. Journal of Immunology, 187(4), 1957–1969. https://doi.org/10.4049/jimmunol.1101305.CrossRef Bento, A. F., Claudino, R. F., Dutra, R. C., Marcon, R., & Calixto, J. B. B. (2011). Omega-3 fatty acidderived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. Journal of Immunology, 187(4), 1957–1969. https://​doi.​org/​10.​4049/​jimmunol.​1101305.CrossRef
313.
Zurück zum Zitat Chiu, C.-Y., Gomolka, B., Dierkes, C., Huang, N. R., Schroeder, M., Purschke, M., et al. (2012). Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis. Inflammation Research, 61(9), 967–976. https://doi.org/10.1007/s00011-012-0489-8.PubMedCrossRef Chiu, C.-Y., Gomolka, B., Dierkes, C., Huang, N. R., Schroeder, M., Purschke, M., et al. (2012). Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis. Inflammation Research, 61(9), 967–976. https://​doi.​org/​10.​1007/​s00011-012-0489-8.PubMedCrossRef
317.
318.
Zurück zum Zitat Kang, G.-J., Lee, H.-J., Kang, Y., Kim, E., Kim, H., Byun, H., et al (2015). High-mobility group box 1 suppresses resolvin D1-induced phagocytosis via induction of resolvin D1-inactivating enzyme, 15-hydroxyprostaglandin dehydrogenase. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852(9), 1981–1988. https://doi.org/10.1016/j.bbadis.2015.07.005.CrossRef Kang, G.-J., Lee, H.-J., Kang, Y., Kim, E., Kim, H., Byun, H., et al (2015). High-mobility group box 1 suppresses resolvin D1-induced phagocytosis via induction of resolvin D1-inactivating enzyme, 15-hydroxyprostaglandin dehydrogenase. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1852(9), 1981–1988. https://​doi.​org/​10.​1016/​j.​bbadis.​2015.​07.​005.CrossRef
319.
321.
Zurück zum Zitat Fredman, G., Ozcan, L., Spolitu, S., Hellmann, J., Spite, M., Backs, J., et al. (2014). Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. Proceedings of the National Academy of Sciences, 111(40), 14530–14535. https://doi.org/10.1073/pnas.1410851111.CrossRef Fredman, G., Ozcan, L., Spolitu, S., Hellmann, J., Spite, M., Backs, J., et al. (2014). Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. Proceedings of the National Academy of Sciences, 111(40), 14530–14535. https://​doi.​org/​10.​1073/​pnas.​1410851111.CrossRef
322.
326.
328.
Zurück zum Zitat Dalli, J., Zhu, M., Vlasenko, N. A., Deng, B., Haeggström, J. Z., Petasis, N. A., et al. (2013). The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 27(7), 2573–2583. https://doi.org/10.1096/fj.13-227728.CrossRef Dalli, J., Zhu, M., Vlasenko, N. A., Deng, B., Haeggström, J. Z., Petasis, N. A., et al. (2013). The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 27(7), 2573–2583. https://​doi.​org/​10.​1096/​fj.​13-227728.CrossRef
332.
333.
Zurück zum Zitat Marcon, R., Bento, A. F., Dutra, R. C., Bicca, M. A., Leite, D. F. P., & Calixto, J. B. (2013). Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. The Journal of Immunology, 191(8), 4288–4298. https://doi.org/10.4049/jimmunol.1202743.PubMedCrossRef Marcon, R., Bento, A. F., Dutra, R. C., Bicca, M. A., Leite, D. F. P., & Calixto, J. B. (2013). Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. The Journal of Immunology, 191(8), 4288–4298. https://​doi.​org/​10.​4049/​jimmunol.​1202743.PubMedCrossRef
334.
Zurück zum Zitat Abdulnour, R.-E. E., Dalli, J., Colby, J. K., Krishnamoorthy, N., Timmons, J. Y., Tan, S., et al. (2014). Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective. Proceedings of the National Academy of Sciences, 111(46), 16526–16531. https://doi.org/10.1073/pnas.1407123111.CrossRef Abdulnour, R.-E. E., Dalli, J., Colby, J. K., Krishnamoorthy, N., Timmons, J. Y., Tan, S., et al. (2014). Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective. Proceedings of the National Academy of Sciences, 111(46), 16526–16531. https://​doi.​org/​10.​1073/​pnas.​1407123111.CrossRef
335.
337.
Zurück zum Zitat Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003). Novel docosatrienes and 17s-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells AUTACOIDS IN ANTI-INFLAMMATION. Journal of Biological Chemistry, 278(17), 14677–14687. https://doi.org/10.1074/jbc.M300218200.PubMedCrossRef Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003). Novel docosatrienes and 17s-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells AUTACOIDS IN ANTI-INFLAMMATION. Journal of Biological Chemistry, 278(17), 14677–14687. https://​doi.​org/​10.​1074/​jbc.​M300218200.PubMedCrossRef
341.
347.
Metadaten
Titel
Oxygenated lipid signaling in tumor-associated macrophages—focus on colon cancer
verfasst von
Jennifer K. Colby
Jonathan Jaoude
Fuyao Liu
Imad Shureiqi
Publikationsdatum
22.06.2018
Verlag
Springer US
Erschienen in
Cancer and Metastasis Reviews / Ausgabe 2-3/2018
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-018-9743-z

Weitere Artikel der Ausgabe 2-3/2018

Cancer and Metastasis Reviews 2-3/2018 Zur Ausgabe

EditorialNotes

Preface

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.