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Journal of Cancer Research and Clinical Oncology

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01.09.2003 | Original Paper

p34^cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma

verfasst von: T. Nozoe, M. Honda, S. Inutsuka, D. Korenaga

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 9/2003

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Abstract

Purpose

The significance of p34^cdc2 expression in human tumors has not been fully explained. The aim of the current study was to elucidate the clinicopathologic significance of immunohistochemical p34^cdc2 expression in carcinoma of the colon and rectum.

Methods

The immunohistochemical expression of p34^cdc2 was examined in 90 consecutive colorectal tumor cases, and p34^cdc2 expression and the clinicopathologic features of the patients and their tumors were compared.

Results

Lymph node metastasis was significantly more frequent in tumors expressing p34^cdc2 (47.8%, 11 of 23 tumors) than in tumors not expressing p34^cdc2 (22.4%, 15 of 67 tumors; P=0.020). Multivariate analysis demonstrated that tumor depth (P=0.008) and p34^cdc2 expression (P=0.022) were independently associated with lymph node metastases of colorectal carcinomas.

Conclusions

The immunohistochemical expression of p34^cdc2 is independently associated with lymph node metastasis in colorectal carcinoma.

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Titel: p34cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma
verfasst von: T. Nozoe
M. Honda
S. Inutsuka
D. Korenaga
Publikationsdatum: 01.09.2003
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 9/2003
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-003-0474-2

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p34^cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma

Abstract

Purpose

Methods

Results

Conclusions

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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