Erschienen in:
01.03.2000 | Meeting abstract
P53 mutations in breast and ovarian carcinomas from BRCA1 and 2 mutation carriers and noncarriers
verfasst von:
E Sensi, C Ghimenti, G Cipollini, D Iandolo, G Naccarato, P Viacava, G Bevilacqua, MA Caligo
Erschienen in:
Breast Cancer Research
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Sonderheft 1/2000
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Excerpt
Breast and ovarian carcinomas occurring in carriers of BRCA1 and 2 gene mutations may have a distinct pathway of molecular pathogenesis from those occurring in noncarriers. Data from murine models suggest that the p53 gene, which is involved in initiating cell cycle arrest and apoptosis in response to DNA damage, may be important in the tumorigenesis of BRCA1 and 2-associated cancers, and its loss of function could be a early critical event in the malignant transformation of cells defective for BRCA1 and 2 genes. Therefore, breast and ovarian tumors from carriers of BRCA1 and 2 alterations might be expected to exhibit a high rate of somatic p53 mutations. …