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2015 | OriginalPaper | Buchkapitel

10. Andere Diabetesformen bei Kindern und Jugendlichen

verfasst von : Prof. Dr. med. Thomas Danne, Prof. Dr. med. Olga Kordonouri, Prof. Dr. rer. nat. Karin Lange

Erschienen in: Diabetes bei Kindern und Jugendlichen

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Der insulinpflichtige, autoimmun-bedingte Typ-1-Diabetes ist die häufigste Diabetesform bei Kindern und Jugendlichen. Es gibt jedoch andere Diabetesformen, die sich bereits im Kindes- und Jugendalter manifestieren können. Dazu gehören der Typ-2-Diabetes bei übergewichtigen bzw. adipösen Kindern mit meistens positiver Familienanamnese für Typ-2-Diabetes und klinischen Zeichen eines Hyperinsulinismus (z. B. Acanthosis nigricans), Diabetes bei genetischen Defekten (z. B. „maturity onset diabetes of the young“, MODY; DIDMOAD-Syndrom, neonataler Diabetes), Diabetes im Rahmen anderer Grunderkrankungen (z. B. bei zystischer Fibrose) sowie der medikamentös induzierter Diabetes.
Literatur
Zurück zum Zitat Awa WL, Fach E, Krakow E, et al. (2012) Type 2 Diabetes from the pediatric to the geriatric age: Analysis of gender and obesity among 120.183 patients of the German/Austrian DPV database. Eur J Endocrinol 167: 245–254PubMed Awa WL, Fach E, Krakow E, et al. (2012) Type 2 Diabetes from the pediatric to the geriatric age: Analysis of gender and obesity among 120.183 patients of the German/Austrian DPV database. Eur J Endocrinol 167: 245–254PubMed
Zurück zum Zitat Copeland KC, Silverstein J, Moore KR, Prazar GE, Raymer T, Shiffman RN, Springer SC, Thaker VV, Anderson M, Spann SJ, Flinn SK; American Academy of Pediatrics (2013) Management of newly diagnosed type 2 Diabetes Mellitus (T2DM) in children and adolescents. Pediatrics 131:364–382PubMedCrossRef Copeland KC, Silverstein J, Moore KR, Prazar GE, Raymer T, Shiffman RN, Springer SC, Thaker VV, Anderson M, Spann SJ, Flinn SK; American Academy of Pediatrics (2013) Management of newly diagnosed type 2 Diabetes Mellitus (T2DM) in children and adolescents. Pediatrics 131:364–382PubMedCrossRef
Zurück zum Zitat Danne T, Kordonouri O (2013) Transatlantic differences in the management of T2DM in youth. Nat Rev Endocrinol 9:263–264PubMedCrossRef Danne T, Kordonouri O (2013) Transatlantic differences in the management of T2DM in youth. Nat Rev Endocrinol 9:263–264PubMedCrossRef
Zurück zum Zitat Diabetes DE, Deutsche Diabetes Hilfe (2014) Deutscher Gesundheitsbericht-Diabetes 2014. Kirchheim, Mainz Diabetes DE, Deutsche Diabetes Hilfe (2014) Deutscher Gesundheitsbericht-Diabetes 2014. Kirchheim, Mainz
Zurück zum Zitat Edghill EL, Flanagan SE, Patch AM, Boustred C, Parrish A, Shields B, Shepherd MH, Hussain K, Kapoor RR, Malecki M, MacDonald MJ, Støy J, Steiner DF, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group, Hattersley AT, Ellard S (2008) Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. Diabetes 57: 1034–1042PubMedCrossRef Edghill EL, Flanagan SE, Patch AM, Boustred C, Parrish A, Shields B, Shepherd MH, Hussain K, Kapoor RR, Malecki M, MacDonald MJ, Støy J, Steiner DF, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group, Hattersley AT, Ellard S (2008) Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. Diabetes 57: 1034–1042PubMedCrossRef
Zurück zum Zitat Fazeli Farsani S, van der Aa MP, van der Vorst MJ, Knibbe CAJ, de Boer A (2012) Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches. Diabetologia 56:1471–1488CrossRef Fazeli Farsani S, van der Aa MP, van der Vorst MJ, Knibbe CAJ, de Boer A (2012) Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches. Diabetologia 56:1471–1488CrossRef
Zurück zum Zitat Flanagan SE, Clauin S, Bellanné-Chantelot C, de Lonlay P, Harries LW, Gloyn AL, Ellard S (2009). Update of mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor (ABCC8) in diabetes mellitus and hyperinsulinism. Hum Mutat 30: 170–180PubMedCrossRef Flanagan SE, Clauin S, Bellanné-Chantelot C, de Lonlay P, Harries LW, Gloyn AL, Ellard S (2009). Update of mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor (ABCC8) in diabetes mellitus and hyperinsulinism. Hum Mutat 30: 170–180PubMedCrossRef
Zurück zum Zitat Flanagan SE, Edghill EL, Gloyn AL, Ellard S, Hattersley AT (2006) Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype. Diabetologia 49:1190–1197PubMedCrossRef Flanagan SE, Edghill EL, Gloyn AL, Ellard S, Hattersley AT (2006) Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype. Diabetologia 49:1190–1197PubMedCrossRef
Zurück zum Zitat Gloyn AL, Pearson ER, Antcliff JF et al. (2004) Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 350: 1838–1849PubMedCrossRef Gloyn AL, Pearson ER, Antcliff JF et al. (2004) Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 350: 1838–1849PubMedCrossRef
Zurück zum Zitat Gloyn AL, Diatloff-Zito C, Edghill EL, Bellanné-Chantelot C, Nivot S, Coutant R, Ellard S, Hattersley AT, Robert JJ (2006) KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. Eur J Hum Genet 14:824–830PubMedCrossRef Gloyn AL, Diatloff-Zito C, Edghill EL, Bellanné-Chantelot C, Nivot S, Coutant R, Ellard S, Hattersley AT, Robert JJ (2006) KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. Eur J Hum Genet 14:824–830PubMedCrossRef
Zurück zum Zitat Koloušková S, Zemková D, Bartošová J, Skalická V, Šumník Z, Vávrová V, Lebl J (2011) Low-dose insulin therapy in patients with cystic fibrosis and early-stage insulinopenia prevents deterioration of lung function: a 3-year prospective study. J Pediatr Endocrinol Metab 24: 449–454PubMed Koloušková S, Zemková D, Bartošová J, Skalická V, Šumník Z, Vávrová V, Lebl J (2011) Low-dose insulin therapy in patients with cystic fibrosis and early-stage insulinopenia prevents deterioration of lung function: a 3-year prospective study. J Pediatr Endocrinol Metab 24: 449–454PubMed
Zurück zum Zitat Lopez de Heredia M, Cleries R, Nunes V (2013) Genotypic classification of patients with Wolfram syndrome: insights into the natural history of the disease and correlation with phenotype. Genet Med 15: 497–506CrossRef Lopez de Heredia M, Cleries R, Nunes V (2013) Genotypic classification of patients with Wolfram syndrome: insights into the natural history of the disease and correlation with phenotype. Genet Med 15: 497–506CrossRef
Zurück zum Zitat Moran A, Pillay K, Becker DJ, Acerini CL (2014) ISPAD Clinical Practice Consensus Guidelines. Management of cystic-fibrosis related diabetes. Pediatr Diabetes 15 (Suppl 20): 65–76 Moran A, Pillay K, Becker DJ, Acerini CL (2014) ISPAD Clinical Practice Consensus Guidelines. Management of cystic-fibrosis related diabetes. Pediatr Diabetes 15 (Suppl 20): 65–76
Zurück zum Zitat Neu A, Feldhahn L, Ehehalt S, Hub R, Ranke MB, DIARY group Baden-Württemberg (2009) Type 2 diabetes mellitus in children and adolescents is still a rare disease in Germany: a population-based assessment of the prevalence of type 2 diabetes and MODY in patients aged 0-20 years. Pediatr Diabetes 10:468–473PubMedCrossRef Neu A, Feldhahn L, Ehehalt S, Hub R, Ranke MB, DIARY group Baden-Württemberg (2009) Type 2 diabetes mellitus in children and adolescents is still a rare disease in Germany: a population-based assessment of the prevalence of type 2 diabetes and MODY in patients aged 0-20 years. Pediatr Diabetes 10:468–473PubMedCrossRef
Zurück zum Zitat Pearson ER, Flechtner I, Njolstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Sovik O, Polak M, Hattersley AT (2006) Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 355:467–477PubMedCrossRef Pearson ER, Flechtner I, Njolstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Sovik O, Polak M, Hattersley AT (2006) Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 355:467–477PubMedCrossRef
Zurück zum Zitat O’Riordan SM, Dattani MT, Hindmarsh PC (2010) Cystic fibrosis-related diabetes in childhood. Horm Res Paediatr 73:15–24PubMedCrossRef O’Riordan SM, Dattani MT, Hindmarsh PC (2010) Cystic fibrosis-related diabetes in childhood. Horm Res Paediatr 73:15–24PubMedCrossRef
Zurück zum Zitat Pinhas-Hamiel O, Zeitler P (2005) The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr 146: 693–700PubMedCrossRef Pinhas-Hamiel O, Zeitler P (2005) The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr 146: 693–700PubMedCrossRef
Zurück zum Zitat Rohayem J, Ehlers C, Wiedemann B, Holl R, Oexle K, Kordonouri O, Salzano G, Meissner T, Burger W, Schober E, Huebner A, Lee-Kirsch MA; Wolfram Syndrome Diabetes Writing Group (2011) Diabetes and neurodegeneration in Wolfram syndrome: a multicenter study of phenotype and genotype Diabetes Care 34:1503–1510PubMedCrossRefPubMedCentral Rohayem J, Ehlers C, Wiedemann B, Holl R, Oexle K, Kordonouri O, Salzano G, Meissner T, Burger W, Schober E, Huebner A, Lee-Kirsch MA; Wolfram Syndrome Diabetes Writing Group (2011) Diabetes and neurodegeneration in Wolfram syndrome: a multicenter study of phenotype and genotype Diabetes Care 34:1503–1510PubMedCrossRefPubMedCentral
Zurück zum Zitat Rubio-Cabezas O, Hattersley AT, Njolstad PR, Mlynarski W, Elland S, White N, Chi DV, Craig ME (2014) ISPAS Clinical Practice Consensus Guidelines. The Diagnosis and Management of Monogenic Diabetes. Pediatr. Diabetes 15 (Suppl 20): 47–64 Rubio-Cabezas O, Hattersley AT, Njolstad PR, Mlynarski W, Elland S, White N, Chi DV, Craig ME (2014) ISPAS Clinical Practice Consensus Guidelines. The Diagnosis and Management of Monogenic Diabetes. Pediatr. Diabetes 15 (Suppl 20): 47–64
Zurück zum Zitat TODAY Study Group, Zeitler P, Hirst K, Pyle L, Linder B, Copeland K, Arslanian S, Cuttler L, Nathan DM, Tollefsen S, Wilfley D, Kaufman F (2012) N Engl J Med 366:2247–2256PubMedCrossRef TODAY Study Group, Zeitler P, Hirst K, Pyle L, Linder B, Copeland K, Arslanian S, Cuttler L, Nathan DM, Tollefsen S, Wilfley D, Kaufman F (2012) N Engl J Med 366:2247–2256PubMedCrossRef
Zurück zum Zitat Wildin RS, Smyk-Pearson S, Filipovich AH (2002). Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 39:537–545PubMedCrossRefPubMedCentral Wildin RS, Smyk-Pearson S, Filipovich AH (2002). Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 39:537–545PubMedCrossRefPubMedCentral
Zurück zum Zitat Zeitler P, Fu J, Tandon N, Nadean K, Urakami T, Bartlett T, Maahs D (2014) ISPAD Clinical Practice Consensus Guidelines. Type 2 Diabetes. Pediatr Diabetes 15 (Suppl 2): 26–46 Zeitler P, Fu J, Tandon N, Nadean K, Urakami T, Bartlett T, Maahs D (2014) ISPAD Clinical Practice Consensus Guidelines. Type 2 Diabetes. Pediatr Diabetes 15 (Suppl 2): 26–46
Metadaten
Titel
Andere Diabetesformen bei Kindern und Jugendlichen
verfasst von
Prof. Dr. med. Thomas Danne
Prof. Dr. med. Olga Kordonouri
Prof. Dr. rer. nat. Karin Lange
Copyright-Jahr
2015
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-24645-6_10

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