Erschienen in:
07.07.2015 | Review Article
Pancreatic regeneration: basic research and gene regulation
verfasst von:
Kenji Okita, Toru Mizuguchi, Ota Shigenori, Masayuki Ishii, Toshihiko Nishidate, Tomomi Ueki, Makoto Meguro, Yasutoshi Kimura, Naoki Tanimizu, Norihisa Ichinohe, Toshihiko Torigoe, Takashi Kojima, Toshihiro Mitaka, Noriyuki Sato, Norimasa Sawada, Koichi Hirata
Erschienen in:
Surgery Today
|
Ausgabe 6/2016
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Abstract
Pancreatic regeneration (PR) is an interesting phenomenon that could provide clues as to how the control of diabetes mellitus might be achieved. Due to the different regenerative abilities of the pancreas and liver, the molecular mechanism responsible for PR is largely unknown. In this review, we describe five representative murine models of PR and thirteen humoral mitogens that stimulate β-cell proliferation. We also describe pancreatic ontogenesis, including the molecular transcriptional differences between α-cells and β-cells. Furthermore, we review 14 murine models which carry defects in genes related to key transcription factors for pancreatic ontogenesis to gain further insight into pancreatic development.