Skip to main content
Erschienen in: Die Radiologie 12/2017

29.11.2017 | Computertomografie | CME

Resektabilitätskriterien beim Pankreaskarzinom und postoperative Bildgebung

verfasst von: Prof. Dr. L. Grenacher, Prof. Dr. M. Juchems

Erschienen in: Die Radiologie | Ausgabe 12/2017

Einloggen, um Zugang zu erhalten

Zusammenfassung

Durch Verbesserung der Techniken der Pankreaschirurgie konnten die Mortalität und die Morbidität für das Pankreaskarzinom deutlich gesenkt werden. Für den Radiologen ist die Kenntnis der Operationstechniken von entscheidender Bedeutung. Nur so können postoperative Komplikationen sicher aufgedeckt und auch Lokalrezidive frühzeitig detektiert werden. Die Komplikationen in der Folge eines pankreaschirurgischen Eingriffs können dabei schwerwiegend sein und erfordern oft einen radiologisch-interventionellen Eingriff. Da das Pankreaskarzinom selbst eine schwerwiegende Erkrankung mit schlechtem Fünfjahresüberleben darstellt, welches nur durch eine R0-Resektion verbessert werden kann, ist es von entscheidender Bedeutung, diejenigen Patienten bildgebend zu identifizieren, die primär operabel sind oder potenziell durch eine neoadjuvante Chemotherapie in einen operablen Zustand versetzt werden können („borderline“), sowie inoperable Patienten nicht zusätzlich durch postoperative Komplikationen zu schwächen und sie stattdessen ohne unnötige Verzögerung einer palliativen Therapie zuzuführen. Hierfür sind die Kenntnisse der Kriterien der Resektabilität sowie der Inoperabilität bei einem Pankreaskarzinom für jeden onkologischen Radiologen heutzutage essenzielles Basiswissen.
Literatur
1.
Zurück zum Zitat Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM (2014) Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 74(11):2913–2921CrossRefPubMed Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM (2014) Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 74(11):2913–2921CrossRefPubMed
2.
3.
Zurück zum Zitat Richter A, Niedergethmann M, Sturm JW, Lorenz D, Post S, Trede M (2003) Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience. World J Surg 27(3):324–329CrossRefPubMed Richter A, Niedergethmann M, Sturm JW, Lorenz D, Post S, Trede M (2003) Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience. World J Surg 27(3):324–329CrossRefPubMed
4.
Zurück zum Zitat Wagner M, Redaelli C, Lietz M, Seiler CA, Friess H, Buchler MW (2004) Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma. Br J Surg 91(5):586–594CrossRefPubMed Wagner M, Redaelli C, Lietz M, Seiler CA, Friess H, Buchler MW (2004) Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma. Br J Surg 91(5):586–594CrossRefPubMed
5.
Zurück zum Zitat Distler M, Ruckert F, Hunger M, Kersting S, Pilarsky C, Saeger HD et al (2013) Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma. BMC Surg 13:12CrossRefPubMedPubMedCentral Distler M, Ruckert F, Hunger M, Kersting S, Pilarsky C, Saeger HD et al (2013) Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma. BMC Surg 13:12CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Brierley J, Gospodarowicz MK, Wittekind C (2016) TNM classification of malignant tumours. Eighth edition ed. 253 pages p. Brierley J, Gospodarowicz MK, Wittekind C (2016) TNM classification of malignant tumours. Eighth edition ed. 253 pages p.
7.
Zurück zum Zitat NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Pancreatic Adenocarcinoma Version 2. Fort Washington, PA: National Comprehensive Cancer Network, Inc (NCCN);2017. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Pancreatic Adenocarcinoma Version 2. Fort Washington, PA: National Comprehensive Cancer Network, Inc (NCCN);2017.
9.
Zurück zum Zitat Callery MP, Chang KJ, Fishman EK, Talamonti MS, William Traverso L, Linehan DC (2009) Pretreatment assessment of resectable and borderline resectable pancreatic cancer: expert consensus statement. Ann Surg Oncol 16(7):1727–1733CrossRefPubMed Callery MP, Chang KJ, Fishman EK, Talamonti MS, William Traverso L, Linehan DC (2009) Pretreatment assessment of resectable and borderline resectable pancreatic cancer: expert consensus statement. Ann Surg Oncol 16(7):1727–1733CrossRefPubMed
10.
Zurück zum Zitat House MG, Yeo CJ, Cameron JL, Campbell KA, Schulick RD, Leach SD et al (2004) Predicting resectability of periampullary cancer with three-dimensional computed tomography. J Gastrointest Surg 8(3):280–288CrossRefPubMed House MG, Yeo CJ, Cameron JL, Campbell KA, Schulick RD, Leach SD et al (2004) Predicting resectability of periampullary cancer with three-dimensional computed tomography. J Gastrointest Surg 8(3):280–288CrossRefPubMed
11.
Zurück zum Zitat Klauss M, Schobinger M, Wolf I, Werner J, Meinzer HP, Kauczor HU et al (2009) Value of three-dimensional reconstructions in pancreatic carcinoma using multidetector CT: initial results. World J Gastroenterol 15(46):5827–5832CrossRefPubMedPubMedCentral Klauss M, Schobinger M, Wolf I, Werner J, Meinzer HP, Kauczor HU et al (2009) Value of three-dimensional reconstructions in pancreatic carcinoma using multidetector CT: initial results. World J Gastroenterol 15(46):5827–5832CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Al-Hawary MM, Francis IR, Chari ST, Fishman EK, Hough DM, Lu DS et al (2014) Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the society of abdominal radiology and the american pancreatic association. Radiology 270(1):248–60 e1CrossRefPubMed Al-Hawary MM, Francis IR, Chari ST, Fishman EK, Hough DM, Lu DS et al (2014) Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the society of abdominal radiology and the american pancreatic association. Radiology 270(1):248–60 e1CrossRefPubMed
13.
Zurück zum Zitat Tamm EP, Balachandran A, Bhosale PR, Katz MH, Fleming JB, Lee JH et al (2012) Imaging of pancreatic adenocarcinoma: update on staging/resectability. Radiol Clin North Am 50(3):407–428CrossRefPubMed Tamm EP, Balachandran A, Bhosale PR, Katz MH, Fleming JB, Lee JH et al (2012) Imaging of pancreatic adenocarcinoma: update on staging/resectability. Radiol Clin North Am 50(3):407–428CrossRefPubMed
14.
Zurück zum Zitat The American Joint Committee on Cancer (2010) Exocrine and endocrine pancreas. In: Edge SB, Byrd DR, Compton CC (Hrsg) AJCC cancer staging manual, 7. Aufl. Springer, New York, S 241–249 The American Joint Committee on Cancer (2010) Exocrine and endocrine pancreas. In: Edge SB, Byrd DR, Compton CC (Hrsg) AJCC cancer staging manual, 7. Aufl. Springer, New York, S 241–249
15.
Zurück zum Zitat Ahmad NA, Kochman ML, Lewis JD, Kadish S, Morris JB, Rosato EF et al (2001) Endosonography is superior to angiography in the preoperative assessment of vascular involvement among patients with pancreatic carcinoma. J Clin Gastroenterol 32(1):54–58CrossRefPubMed Ahmad NA, Kochman ML, Lewis JD, Kadish S, Morris JB, Rosato EF et al (2001) Endosonography is superior to angiography in the preoperative assessment of vascular involvement among patients with pancreatic carcinoma. J Clin Gastroenterol 32(1):54–58CrossRefPubMed
16.
Zurück zum Zitat Arslan A, Buanes T, Geitung JT (2001) Pancreatic carcinoma: MR, MR angiography and dynamic helical CT in the evaluation of vascular invasion. Eur J Radiol 38(2):151–159CrossRefPubMed Arslan A, Buanes T, Geitung JT (2001) Pancreatic carcinoma: MR, MR angiography and dynamic helical CT in the evaluation of vascular invasion. Eur J Radiol 38(2):151–159CrossRefPubMed
17.
Zurück zum Zitat Brugel M, Rummeny EJ, Dobritz M (2004) Vascular invasion in pancreatic cancer: value of multislice helical CT. Abdom Imaging 29(2):239–245CrossRefPubMed Brugel M, Rummeny EJ, Dobritz M (2004) Vascular invasion in pancreatic cancer: value of multislice helical CT. Abdom Imaging 29(2):239–245CrossRefPubMed
18.
Zurück zum Zitat DeWitt J, Devereaux B, Chriswell M, McGreevy K, Howard T, Imperiale TF et al (2004) Comparison of endoscopic ultrasonography and multidetector computed tomography for detecting and staging pancreatic cancer. Ann Intern Med 141(10):753–763CrossRefPubMed DeWitt J, Devereaux B, Chriswell M, McGreevy K, Howard T, Imperiale TF et al (2004) Comparison of endoscopic ultrasonography and multidetector computed tomography for detecting and staging pancreatic cancer. Ann Intern Med 141(10):753–763CrossRefPubMed
19.
Zurück zum Zitat Phoa SS, Tilleman EH, van Delden OM, Bossuyt PM, Gouma DJ, Lameris JS (2005) Value of CT criteria in predicting survival in patients with potentially resectable pancreatic head carcinoma. J Surg Oncol 91(1):33–40CrossRefPubMed Phoa SS, Tilleman EH, van Delden OM, Bossuyt PM, Gouma DJ, Lameris JS (2005) Value of CT criteria in predicting survival in patients with potentially resectable pancreatic head carcinoma. J Surg Oncol 91(1):33–40CrossRefPubMed
20.
Zurück zum Zitat Soriano A, Castells A, Ayuso C, Ayuso JR, de Caralt MT, Gines MA et al (2004) Preoperative staging and tumor resectability assessment of pancreatic cancer: prospective study comparing endoscopic ultrasonography, helical computed tomography, magnetic resonance imaging, and angiography. Am J Gastroenterol 99(3):492–501CrossRefPubMed Soriano A, Castells A, Ayuso C, Ayuso JR, de Caralt MT, Gines MA et al (2004) Preoperative staging and tumor resectability assessment of pancreatic cancer: prospective study comparing endoscopic ultrasonography, helical computed tomography, magnetic resonance imaging, and angiography. Am J Gastroenterol 99(3):492–501CrossRefPubMed
21.
Zurück zum Zitat Gilbert JW, Wolpin B, Clancy T et al (2017) Borderline resectable pancreatic cancer: conceptual evolution and current approach to image-based classification. Ann Oncol 28:2067–2076CrossRefPubMed Gilbert JW, Wolpin B, Clancy T et al (2017) Borderline resectable pancreatic cancer: conceptual evolution and current approach to image-based classification. Ann Oncol 28:2067–2076CrossRefPubMed
22.
Zurück zum Zitat Egorov VI, Petrov RV, Solodinina EN, Karmazanovsky GG, Starostina NS, Kuruschkina NA (2013) Computed tomography-based diagnostics might be insufficient in the determination of pancreatic cancer unresectability. World J Gastrointest Surg 5(4):83–96CrossRefPubMedPubMedCentral Egorov VI, Petrov RV, Solodinina EN, Karmazanovsky GG, Starostina NS, Kuruschkina NA (2013) Computed tomography-based diagnostics might be insufficient in the determination of pancreatic cancer unresectability. World J Gastrointest Surg 5(4):83–96CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Anis M, Mortele K (2013) Role of secretin-enhanced magnetic resonance cholangiopancreatography in the evaluation of patients following pancreatojejunostomy. J Clin Imaging Sci 3:7CrossRefPubMedPubMedCentral Anis M, Mortele K (2013) Role of secretin-enhanced magnetic resonance cholangiopancreatography in the evaluation of patients following pancreatojejunostomy. J Clin Imaging Sci 3:7CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Schnelldorfer T, Ware AL, Sarr MG, Smyrk TC, Zhang L, Qin R et al (2008) Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible? Ann Surg 247(3):456–462CrossRefPubMed Schnelldorfer T, Ware AL, Sarr MG, Smyrk TC, Zhang L, Qin R et al (2008) Long-term survival after pancreatoduodenectomy for pancreatic adenocarcinoma: is cure possible? Ann Surg 247(3):456–462CrossRefPubMed
26.
Zurück zum Zitat Manser C (2013) Erkrankungen des Pankreas. In: Luscher T, Steffel J (Hrsg) Magen-Darm-Trakt. Springer, Berlin Heidelberg Manser C (2013) Erkrankungen des Pankreas. In: Luscher T, Steffel J (Hrsg) Magen-Darm-Trakt. Springer, Berlin Heidelberg
27.
Zurück zum Zitat Traverso LW, Longmire WP Jr. (1978) Preservation of the pylorus in pancreaticoduodenectomy. Surg Gynecol Obstet 146(6):959–962PubMed Traverso LW, Longmire WP Jr. (1978) Preservation of the pylorus in pancreaticoduodenectomy. Surg Gynecol Obstet 146(6):959–962PubMed
28.
Zurück zum Zitat Donahue TR, Reber HA (2015) Surgical management of pancreatic cancer—pancreaticoduodenectomy. Semin Oncol 42(1):98–109CrossRefPubMed Donahue TR, Reber HA (2015) Surgical management of pancreatic cancer—pancreaticoduodenectomy. Semin Oncol 42(1):98–109CrossRefPubMed
29.
Zurück zum Zitat Greenblatt DY, Kelly KJ, Rajamanickam V, Wan Y, Hanson T, Rettammel R et al (2011) Preoperative factors predict perioperative morbidity and mortality after pancreaticoduodenectomy. Ann Surg Oncol 18(8):2126–2135CrossRefPubMed Greenblatt DY, Kelly KJ, Rajamanickam V, Wan Y, Hanson T, Rettammel R et al (2011) Preoperative factors predict perioperative morbidity and mortality after pancreaticoduodenectomy. Ann Surg Oncol 18(8):2126–2135CrossRefPubMed
30.
Zurück zum Zitat Cameron JL, He J (2015) Two thousand consecutive pancreaticoduodenectomies. J Am Coll Surg 220(4):530–536CrossRefPubMed Cameron JL, He J (2015) Two thousand consecutive pancreaticoduodenectomies. J Am Coll Surg 220(4):530–536CrossRefPubMed
31.
Zurück zum Zitat He J, Ahuja N, Makary MA, Cameron JL, Eckhauser FE, Choti MA et al (2014) 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. HPB (Oxford) 16(1):83–90CrossRef He J, Ahuja N, Makary MA, Cameron JL, Eckhauser FE, Choti MA et al (2014) 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. HPB (Oxford) 16(1):83–90CrossRef
32.
Zurück zum Zitat Lermite E, Sommacale D, Piardi T, Arnaud JP, Sauvanet A, Dejong CH et al (2013) Complications after pancreatic resection: diagnosis, prevention and management. Clin Res Hepatol Gastroenterol 37(3):230–239CrossRefPubMed Lermite E, Sommacale D, Piardi T, Arnaud JP, Sauvanet A, Dejong CH et al (2013) Complications after pancreatic resection: diagnosis, prevention and management. Clin Res Hepatol Gastroenterol 37(3):230–239CrossRefPubMed
33.
Zurück zum Zitat Gong H, Ma R, Gong J, Cai C, Song Z, Xu B (2016) Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic cancer: a systematic review and meta-analysis. Medicine (Baltimore) 95(10):e3061CrossRef Gong H, Ma R, Gong J, Cai C, Song Z, Xu B (2016) Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic cancer: a systematic review and meta-analysis. Medicine (Baltimore) 95(10):e3061CrossRef
34.
Zurück zum Zitat Lillemoe KD, Kaushal S, Cameron JL, Sohn TA, Pitt HA, Yeo CJ (1999) Distal pancreatectomy: indications and outcomes in 235 patients. Ann Surg 229(5):693–698 (discussion 8–700)CrossRefPubMedPubMedCentral Lillemoe KD, Kaushal S, Cameron JL, Sohn TA, Pitt HA, Yeo CJ (1999) Distal pancreatectomy: indications and outcomes in 235 patients. Ann Surg 229(5):693–698 (discussion 8–700)CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Ricci C, Casadei R, Taffurelli G, Toscano F, Pacilio CA, Bogoni S et al (2015) Laparoscopic versus open distal pancreatectomy for ductal adenocarcinoma: a systematic review and meta-analysis. J Gastrointest Surg 19(4):770–781CrossRefPubMed Ricci C, Casadei R, Taffurelli G, Toscano F, Pacilio CA, Bogoni S et al (2015) Laparoscopic versus open distal pancreatectomy for ductal adenocarcinoma: a systematic review and meta-analysis. J Gastrointest Surg 19(4):770–781CrossRefPubMed
36.
Zurück zum Zitat Seufferlein T, Porzner M, Becker T, Budach V, Ceyhan G, Esposito I et al (2013) S3-guideline exocrine pancreatic cancer. Z Gastroenterol 51(12):1395–1440CrossRefPubMed Seufferlein T, Porzner M, Becker T, Budach V, Ceyhan G, Esposito I et al (2013) S3-guideline exocrine pancreatic cancer. Z Gastroenterol 51(12):1395–1440CrossRefPubMed
37.
Zurück zum Zitat Ducreux M, Cuhna AS, Caramella C, Hollebecque A, Burtin P, Goere D et al (2015) Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 26(Suppl 5):v56–v68CrossRefPubMed Ducreux M, Cuhna AS, Caramella C, Hollebecque A, Burtin P, Goere D et al (2015) Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 26(Suppl 5):v56–v68CrossRefPubMed
38.
Zurück zum Zitat Heye T, Zausig N, Klauss M, Singer R, Werner J, Richter GM et al (2011) CT diagnosis of recurrence after pancreatic cancer: is there a pattern? World J Gastroenterol 17(9):1126–1134CrossRefPubMedPubMedCentral Heye T, Zausig N, Klauss M, Singer R, Werner J, Richter GM et al (2011) CT diagnosis of recurrence after pancreatic cancer: is there a pattern? World J Gastroenterol 17(9):1126–1134CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat Asagi A, Ohta K, Nasu J, Tanada M, Nadano S, Nishimura R et al (2013) Utility of contrast-enhanced FDG-PET/CT in the clinical management of pancreatic cancer: impact on diagnosis, staging, evaluation of treatment response, and detection of recurrence. Pancreas 42(1):11–19CrossRefPubMed Asagi A, Ohta K, Nasu J, Tanada M, Nadano S, Nishimura R et al (2013) Utility of contrast-enhanced FDG-PET/CT in the clinical management of pancreatic cancer: impact on diagnosis, staging, evaluation of treatment response, and detection of recurrence. Pancreas 42(1):11–19CrossRefPubMed
40.
Zurück zum Zitat Ruf J, Lopez Hanninen E, Oettle H, Plotkin M, Pelzer U, Stroszczynski C et al (2005) Detection of recurrent pancreatic cancer: comparison of FDG-PET with CT/MRI. Pancreatology 5(2–3):266–272CrossRefPubMed Ruf J, Lopez Hanninen E, Oettle H, Plotkin M, Pelzer U, Stroszczynski C et al (2005) Detection of recurrent pancreatic cancer: comparison of FDG-PET with CT/MRI. Pancreatology 5(2–3):266–272CrossRefPubMed
Metadaten
Titel
Resektabilitätskriterien beim Pankreaskarzinom und postoperative Bildgebung
verfasst von
Prof. Dr. L. Grenacher
Prof. Dr. M. Juchems
Publikationsdatum
29.11.2017
Verlag
Springer Medizin
Erschienen in
Die Radiologie / Ausgabe 12/2017
Print ISSN: 2731-7048
Elektronische ISSN: 2731-7056
DOI
https://doi.org/10.1007/s00117-017-0326-8

Weitere Artikel der Ausgabe 12/2017

Die Radiologie 12/2017 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.