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Erschienen in: Lasers in Dental Science 1/2023

24.02.2023 | Original Article

Paramagnetic resonance spectroscopy of the 3-maleimido-proxyl (3-MP) scavenging properties of three photoactive substances in the context of photodynamic therapy—a pilot study

verfasst von: Mihail Tanev, Georgi Tomov, Yanka Karamalakova

Erschienen in: Lasers in Dental Science | Ausgabe 1/2023

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Abstract

Purpose

Photodynamic therapy is a novel therapeutic approach aimed primarily as an antibacterial method for the oral cavity. However, being a low-level laser therapy, photodynamic therapy could possibly show potential as a modulative method in managing aspects of the inflammation process in the oral tissues.

Methods

The presented study uses EPR to explore the relationship between three common photosensitizers and 3-maleimido-proxyl which is a marker for conformational changes in the albumin structure. Albumins are proteins which take central part in the inflammatory cascade in the body including the oral tissues.

Results

The results show the pronounced potential of the tested photoactive molecules to restore the albumin molecule and neutralize oxidative stress in the tissues.

Conclusions

Photodynamic therapy-induced restoration of the albumin molecule in oral tissues with selected photoactive substances could be a viable inflammation-modulating pathway.
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Metadaten
Titel
Paramagnetic resonance spectroscopy of the 3-maleimido-proxyl (3-MP) scavenging properties of three photoactive substances in the context of photodynamic therapy—a pilot study
verfasst von
Mihail Tanev
Georgi Tomov
Yanka Karamalakova
Publikationsdatum
24.02.2023
Verlag
Springer International Publishing
Erschienen in
Lasers in Dental Science / Ausgabe 1/2023
Elektronische ISSN: 2367-2587
DOI
https://doi.org/10.1007/s41547-023-00175-4

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