Erschienen in:
06.11.2017 | Case Report
Paraneoplastic Stiff Person Syndrome Secondary to Pancreatic Adenocarcinoma
verfasst von:
Stephanie Yu Shan Yong, Jin Yao Teo, Kok Pin Yong, Brian K. P. Goh
Erschienen in:
Journal of Gastrointestinal Surgery
|
Ausgabe 1/2018
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Excerpt
Stiff person syndrome (SPS) is a rare neurological disorder, characterised by progressive fluctuating muscular rigidity and spasms. Although the exact pathogenesis is unclear, glutamic acid decarboxylase (GAD) antibody, the enzyme responsible for the synthesis of γ-aminobutyric acid (GABA), is found in approximately 60 to 80% of SPS patients.
1,
2 Up to 5% of all SPS patients are associated with malignancies;
3 however, paraneoplastic SPS is usually not associated with anti-GAD antibodies but with anti-amphiphysin or anti-gephyrin antibodies.
4,
5 …