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01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Journal of Medical Case Reports 1/2016

Paraneoplastic syndrome – unresponsive systemic hypertension and fever as expression of primitive ciliary body carcinoma in a blind painful eye: a case report

Zeitschrift:
Journal of Medical Case Reports > Ausgabe 1/2016
Autoren:
Laura Balia, Paolo Vinciguerra, Alessandra Di Maria, Raffaele Piscopo, Mary Romano
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

PV diagnosed the cancer, interpreted patient data and provided critical intellectual content. ADM and LB treated the patient and prepared the figures. RP and MR drafted the manuscript, interpreted patient data, wrote the manuscript and provided critical intellectual content. All authors read and approved the final manuscript.

Abstract

Background

The purpose of this study was to present a case of paraneoplastic systemic hypertension and fever in an undiagnosed primary ciliary body carcinoma arising in a painful blind eye.

Case presentation

A 37-year-old white man with a history of blindness since childhood was enucleated for neovascular glaucoma because of intractable pain in his right eye. A histopathological examination revealed a ciliary body carcinoma. One year later, an invasive recurrence of his orbit and ethmoid was detected and a debulking procedure was performed. He had untreatable fever and multidrug-resistant systemic hypertension for 3 months before the neoplasm diagnosis. He recovered from fever and systemic hypertension only after tumor excision and relapsed 1 year later when synchronous tumor dissemination was shown through a computed tomography scan. Tumor metastases, despite surgery and chemotherapy, caused his death.

Conclusions

Paraneoplastic symptoms such as fever and hypertension may be due to unrecognized ocular malignancy. This case report intends to emphasize the importance of histopathological examination of an enucleated phthisical painful blind eye.

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Literatur
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