The online version of this article (doi:10.1186/1477-7819-10-121) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
KPP conceived and coordinated the study. SM, PM, PKI, and LM gathered the data. MB and AC prepared the database and analyzed the data. NF and KM examined the histological material. SM drafted the tables. KPP and AC wrote the manuscript. All authors read and approved the final manuscript.
Parathyroid metastatic disease from thyroid cancer has not been studied extensively, mainly due to the need for parathyroid preservation during thyroid surgery.
We reviewed files from 1,770 patients with thyroid cancer followed up in our department and 10 patients with parathyroid metastases (0.5%) were identified. Patient and tumor characteristics were recorded.
Six out of ten patients had metastases from papillary thyroid cancer, three from follicular thyroid cancer and one from anaplastic thyroid cancer. In nine patients parathyroid infiltration from thyroid cancer was found in direct contact with the thyroid cancer, and in one patient metastatic foci were observed not in continuity with the thyroid cancer.
Parathyroid involvement, although infrequent, may occur in thyroid cancer independently of patient age and tumor size. The clinical significance of such event is not clear. The influence on disease outcome remains to be elucidated.
Tang W, Kakudo K, Nakamura MY, Nakamura M, Mori I, Morita S, Miyauchi A: Parathyroid gland involvement by papillary carcinoma of the thyroid gland. Arch Pathol Lab Med. 2002, 126: 1511-1514. PubMed
Ito Y, Kakudo K, Hirokawa M, Fukushima M, Tomoda C, Inoue H, Kihara M, Higashiyama T, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Miyauchi A: Clinical significance of extrathyroid extension to the parathyroid gland of papillary thyroid carcinoma. Endocr J. 2009, 56: 251-255. 10.1507/endocrj.K08E-297. CrossRefPubMed
Pazaitou-Panayiotou K, Kaprara A, Boudina M, Georgiou E, Drimonitis A, Vainas I, Raptou E, Galaktidou G: Thyroid carcinoma in children and adolescents: presentation, clinical course, and outcome of therapy in 23 children and adolescents in Northern Greece. Hormones (Athens). 2005, 4: 213-220. CrossRef
Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM: Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009, 19: 1167-1214. 10.1089/thy.2009.0110. CrossRefPubMed
- Parathyroid involvement in thyroid cancer: an unforeseen event
Paschalia K Iliadou
- BioMed Central
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