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01.03.2012 | Original Article | Ausgabe 3/2012

Langenbeck's Archives of Surgery 3/2012

Parenchyma-preserving hepatic resection for colorectal liver metastases

Zeitschrift:
Langenbeck's Archives of Surgery > Ausgabe 3/2012
Autoren:
Maximilian von Heesen, Jochen Schuld, Jens Sperling, Frank Grünhage, Frank Lammert, Sven Richter, Martin K. Schilling, Otto Kollmar

Abstract

Background

Hepatic resection of colorectal liver metastases is the only curative treatment option. As clinical and experimental data indicate that the extent of liver resection correlates with growth of residual metastases, the present study analyzes the potential benefit of a parenchyma-preserving liver surgery approach.

Methods

Data from a prospectively maintained database of patients undergoing liver resection for colorectal metastases were reviewed. Evaluation of outcome was performed using the Kaplan–Meier method. Correlations were calculated between clinical–pathological variables.

Results

One hundred sixty-three patients underwent 198 liver resections for colorectal metastases: 26 major hepatectomies, 65 minor anatomical resections, 78 non-anatomical resections, as well as 29 combinations of minor anatomical and non-anatomical procedures. Overall 1-, 3-, and 5-year survival was 93%, 62%, and 40%, respectively. Patients with repeated liver resections had a 5-year survival of 27%. Interestingly, large dissection areas were associated with a significant reduction of the 5-year survival rate (33%). Five-year survival after major hepatectomy was not significantly reduced.

Conclusion

For colorectal liver metastases, minor resections offer a prolonged survival compared to major hepatectomies. As patients with stage IV colorectal disease are candidates for repeat resections, preservation of hepatic parenchyma is of increasing importance in the setting of multi-modal and repeated therapy approaches.

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