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Current Breast Cancer Reports

Erschienen in:

28.07.2017 | Clinical Trials (PF Peddi, Section Editor)

PARP Inhibitors in Breast Cancer: Latest Evidence

verfasst von: Ryan M. Ponec, Parvin Peddi, Rena D. Callahan

Erschienen in: Current Breast Cancer Reports | Ausgabe 3/2017

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Abstract

Purpose of Review

Breast cancer treatment continues to evolve as targeted therapeutic strategies are developed for the various molecular subtypes of breast cancer. The PARP inhibitors represent a novel targeted therapy for tumors with defective homologous recombination DNA repair. These agents may become standard new treatment options for patients harboring BRCA1/2 mutations and show promise in BRCA1/2 wild-type patients with triple-negative breast cancers, which are treated predominantly with traditional cytotoxic chemotherapy. This review will discuss the results of clinical trials of these agents in breast cancer as well as important ongoing and anticipated trials.

Recent Findings

Recent reports support the use of olaparib monotherapy in BRCA1/2-mutated metastatic cancer. Results of PARP inhibitor combinations with chemotherapy have been mixed. The addition of veliparib failed to improve pathological complete response rates in patients with early-stage triple-negative breast cancer treated with carboplatin (AUC6) and paclitaxel followed by doxorubicin plus cyclophosphamide in a phase 3 trial. The PARP inhibitors talazoparib and olaparib are currently being tested in the neoadjuvant and adjuvant settings but impact on survival measures will likely take years prior to reporting in these early-stage breast cancer studies.

Summary

While data from the first phase 3 trials of PARP inhibitors in breast cancers are encouraging in patients with germline deleterious BRCA1/2 mutations, continued work is needed to elucidate their utility beyond the BRCA1/2-mutated population as has been possible in ovarian cancer. Additionally, defining the ideal population and setting for combination treatment remains a challenge and has been limited by synergistic toxicities.

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Titel: PARP Inhibitors in Breast Cancer: Latest Evidence
verfasst von: Ryan M. Ponec
Parvin Peddi
Rena D. Callahan
Publikationsdatum: 28.07.2017
Verlag: Springer US
Erschienen in: Current Breast Cancer Reports / Ausgabe 3/2017
Print ISSN: 1943-4588
Elektronische ISSN: 1943-4596
DOI: https://doi.org/10.1007/s12609-017-0251-x

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PARP Inhibitors in Breast Cancer: Latest Evidence