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Erschienen in: Pituitary 2/2018

05.02.2018

Pathogenesis of non-functioning pituitary adenomas

verfasst von: Maria Chiara Zatelli

Erschienen in: Pituitary | Ausgabe 2/2018

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Abstract

The pathogenesis of non functioning pituitary adenomas (NFPA) is a complex process involving several factors, from molecular to genetic and epigenetic modifications, where tumor suppressor genes, oncogenes, cell cycle derangements have been demonstrated to play an important role. MicroRNAs (miRNAs) have also been identified as possible players in NFPA tumorigenesis and pituitary stem cells have been investigated for their potential role in pituitary tumor initiation. However, a critical role for paracrine signalling has also been highlighted. This review focuses on the current knowledge on the involvement of these factors in NFPA pathogenesis.
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Metadaten
Titel
Pathogenesis of non-functioning pituitary adenomas
verfasst von
Maria Chiara Zatelli
Publikationsdatum
05.02.2018
Verlag
Springer US
Erschienen in
Pituitary / Ausgabe 2/2018
Print ISSN: 1386-341X
Elektronische ISSN: 1573-7403
DOI
https://doi.org/10.1007/s11102-018-0874-6

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