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Seminars in Immunopathology

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01.05.2019 | Introduction

Pathogenicity of acquired immunity in human diseases

verfasst von: Kiyoshi Hirahara

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2019

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CD4⁺ helper T cells help the function of other immune cells and are thereby critical immune cells for the host defense against infection with harmful microorganisms. Thus, this population plays a central role in adaptive immunity. However, CD4⁺ helper T cells can also be involved in the pathology of various immune-related inflammatory diseases, including allergic diseases and auto-immune diseases [1, 2] (Fig. 1). In the classical point of view, helper T cells were recognized to have two major fates, T helper 1 (Th1) and Th2 cells, but recent advances in research have revealed opportunities for diverse helper T cell subsets, beyond Th1 and Th2 cells. The new subsets of helper T cells include follicular helper T (Tfh) cells, Th9, Th17, Th22, and different types of regulatory T cells [3‐6]. …

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Titel: Pathogenicity of acquired immunity in human diseases
verfasst von: Kiyoshi Hirahara
Publikationsdatum: 01.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 3/2019
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-019-00739-2

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Pathogenicity of acquired immunity in human diseases

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Weitere Artikel der Ausgabe 3/2019

Correction to: The pathogenicity of Th17 cells in autoimmune diseases

Epigenetic regulation of T helper cells and intestinal pathogenicity

A new therapeutic target: the CD69-Myl9 system in immune responses

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