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Rheumatology International

Erschienen in:

01.02.2010 | Original Article

Pathologic changes of Achilles tendon in leptin-deficient mice

verfasst von: Jinfei Ji, Zuyu wang, Dongquan Shi, Xiang Gao, Qing Jiang

Erschienen in: Rheumatology International | Ausgabe 4/2010

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Abstract

The objective of this study is to explore whether diabetes play roles on histopathological change of Achilles tendon in leptin-deficient mice. Ob mice (specific-pathogen free SPF) were identified at 10 days after birth and killed via dislocation of cervical spine at 12 weeks. Achilles tendon was isolated as quickly as possible and histopathological changes were investigated. Degeneration of tendinocytes, vascular proliferation, chondrocyte-like tendon cell and ruptures at insertion areas were observed. We conclude that diabetes is associated with histopathologic change in Achilles tendon of ob mice.

Drel VR, Mashtalir N et al (2006) The leptin-deficient (obob) mouse a new animal model of peripheral neuropathy of type 2 diabetes and obesity. Diabetes 55:3335–3343. doi:10.2337/db06-0885 CrossRefPubMed

Hasty AH, Shimano H et al (2001) Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 276(40):37402–37408. doi:10.1074/jbc.M010176200 CrossRefPubMed

Haluzik M, Colombo C, Gavrilova O et al (2004) Genetic background (C57BL/6J Versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 145(7):3258–3264. doi:10.1210/en.2004-0219 CrossRefPubMed

Ozata M, Caglayan S, Ozgemir I, Licinio J (1999) Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 84(10):3686–3695CrossRefPubMed

Khan KM, Cook JL, Bonar F et al (1999) Histopathology of common tendinopathies. Update and implications for clinical management. Sports Med 27(6):393–408CrossRefPubMed

Gill GV, English PJ, Eyes B et al (2007) Painless rupture of the Achilles tendon in a diabetic patient with sensory neuropathy. Pract Diabetes Int 24(1):29–30. doi:10.1002/pdi.1043 CrossRef

Batista F, Nery C, Pinzur M et al (2008) Achilles tendinopathy in diabetes mellitus. Foot Ankle Int 29(5):498–501. doi:10.3113/FAI.2008.0498

Rao SR, Saltzman CL, Wilken J et al (2006) Increased passive ankle stiffness and reduced dorsiflexion range of motion in individuals with diabetes mellitus. Foot Ankle Int 27(8):617–622PubMed

William P, Grant DPM, Eric J et al (2005) Evaluation of Young’s Modulus in Achilles tendons with diabetic neuroarthropathy. J Am Podiatr Med Assoc 95(3):242–246

10.

Holmes GB, Lin J (2006) Etiologic factors associated with symptomatic Achilles tendinopathy. Foot Ankle Int 27(8):952–959PubMed

11.

Qu J, Yu Z (2003) Practical sports medicine. Peking University Medical Press, pp 500–505

12.

Ramana KV, Chandra D, Srivastava S et al (2002) Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. J Biol Chem 227(35):32063–32070. doi:10.1074/jbc.M202126200 CrossRef

13.

Nishikawa T, Edelstein D, Du XL et al (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404(13):787–790PubMed

14.

Koya D, Jirousek MR, Lin YM et al (1997) Characterization of protein kinase C beta isofoem activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest 100(1):115–126. doi:10.1172/JCI119503 CrossRefPubMed

15.

Jifrvinen M, Jozsa L, Kannus P et al (1997) Histopathological findings in chronic tendon disorders. Scand J Med Sci Sports 7:86–95CrossRef

16.

Jozsa L, Kannus P (1997) Histopathological findings in spontaneous tendon ruptures. Scand J Med Sci Sports 7:113–118PubMed

17.

Rolf CG, Fu BSC, Pau A et al (2001) Increased cell proliferation and associated expression of PDGFR β causing hypercellularity in patellar tendinosis. Rheumatology 40:256–261. doi:10.1093/rheumatology/40.3.256 CrossRefPubMed

18.

Fu SC, Chan BP, Wang W et al (2002) Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis. Acta Orthop Scand 73(6):658–662. doi:10.1080/000164702321039624 CrossRefPubMed

19.

Clancy WGJ (1990) Tendon trauma and overuse injuries. In: Leadbetter WB, Buckwalter JA, Gordon SL (eds) Sports-induced inflammation: clinical and basic science concepts. American Academy of Orthopaedic Surgeons, Park Ridge, pp 609–618

Titel: Pathologic changes of Achilles tendon in leptin-deficient mice
verfasst von: Jinfei Ji
Zuyu wang
Dongquan Shi
Xiang Gao
Qing Jiang
Publikationsdatum: 01.02.2010
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 4/2010
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-1001-9

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