Pathologic Factors Associated with Low Risk of Lymph Node Metastasis in Nonmucinous Adenocarcinoma of the Appendix
- 05.01.2022
- Gastrointestinal Oncology
Erschienen in:
- Verfasst von
- Richard J. Straker III, MD
- Samuel Z. Grinberg, BA
- Cimarron E. Sharon, MD
- Adrienne B. Shannon, MD
- Douglas L. Fraker, MD
- Skandan Shanmugan, MD
- John T. Miura, MD
- Giorgos C. Karakousis, MD
- Erschienen in
- Annals of Surgical Oncology | Ausgabe 4/2022
Abstract
Background
Right hemicolectomy (RHC) for nodal staging is recommended for nonmucinous adenocarcinoma of the appendix (NMACA), but it is unclear whether a subgroup of patients at low risk for lymph node (LN) metastasis exists who may be managed with a less extensive resection.
Patients and Methods
Patients with NMACA without distant metastases who underwent margin negative resection via either RHC or appendectomy/partial colectomy (A/PC) were evaluated from the National Cancer Database (2004–2016). Patients at low risk for LN metastasis were identified. Multivariable survival analysis was performed, and 5-year overall survival (OS) was estimated.
Results
Of the 2487 patients included, 652 [26.2%; 95% confidence interval (CI) 24.5–28.0%] had LN metastases. T4 T stage [odds ratio (OR) 4.2, p = 0.032], poorly/undifferentiated histology (OR 2.2, p = 0.004), and lymphovascular invasion (LVI) (OR 4.4, p < 0.001) were associated with LN positivity. One hundred and thirteen patients (4.5%) had tumors at low risk for LN metastasis (T1 T stage, well/moderately differentiated tumors without LVI), and the rate of LN metastasis for this group was 1.8% (95% CI 0.5–6.2%). Conversely, the LN metastasis rate among the 2374 non-low-risk patients was 27.4% (95% CI 25.6–29.2%). Performance of A/PC instead of RHC was associated with a survival disadvantage among all patients (hazards ratio 1.5, p = 0.049), but among the low-risk cohort, 5-year OS did not differ based on resection type (88.3% A/PC versus 92.7% RHC, p = 0.305).
Conclusions
Although relatively uncommon, early, pathologically favorable NMACA is associated with a very low risk of LN metastasis. These select patients may be managed with a less extensive resection without compromising oncologic outcomes.
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- Titel
- Pathologic Factors Associated with Low Risk of Lymph Node Metastasis in Nonmucinous Adenocarcinoma of the Appendix
- Verfasst von
-
Richard J. Straker III, MD
Samuel Z. Grinberg, BA
Cimarron E. Sharon, MD
Adrienne B. Shannon, MD
Douglas L. Fraker, MD
Skandan Shanmugan, MD
John T. Miura, MD
Giorgos C. Karakousis, MD
- Publikationsdatum
- 05.01.2022
- Verlag
- Springer International Publishing
- Erschienen in
-
Annals of Surgical Oncology / Ausgabe 4/2022
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681 - DOI
- https://doi.org/10.1245/s10434-021-11213-5
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