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26.10.2019 | Review Paper

Pathological features of vessel co-option versus sprouting angiogenesis

verfasst von: Emily Latacz, Elisabetta Caspani, Raymond Barnhill, Claire Lugassy, Cornelis Verhoef, Dirk Grünhagen, Steven Van Laere, Carlos Fernández Moro, Marco Gerling, Marie Dirix, Luc Y. Dirix, Peter B. Vermeulen

Erschienen in: Angiogenesis | Ausgabe 1/2020

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Abstract

Cancer cells can use existing blood vessels to acquire a vasculature. This process is termed ‘vessel co-option’. Vessel co-option is an alternative to the growth of new blood vessels, or angiogenesis, and is adopted by a wide range of human tumour types growing within numerous tissues. A complementary aspect of this process is extravascular migratory tumour spread using the co-opted blood vessels as a trail. Vessel co-opting tumours can be discriminated from angiogenic tumours by specific morphological features. These features give rise to distinct histopathological growth patterns that reflect the interaction of cancer cells with the microenvironment of the organ in which they thrive. We will discuss the histopathological growth patterns of vessel co-option in the brain, the liver and the lungs. The review will also highlight evidence for the potential clinical value of the histopathological growth patterns of cancer. Vessel co-option can affect patient outcomes and resistance to cancer treatment. Insight into the biological drivers of this process of tumour vascularization will yield novel therapeutic strategies.

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Titel: Pathological features of vessel co-option versus sprouting angiogenesis
verfasst von: Emily Latacz
Elisabetta Caspani
Raymond Barnhill
Claire Lugassy
Cornelis Verhoef
Dirk Grünhagen
Steven Van Laere
Carlos Fernández Moro
Marco Gerling
Marie Dirix
Luc Y. Dirix
Peter B. Vermeulen
Publikationsdatum: 26.10.2019
Verlag: Springer Netherlands
Erschienen in: Angiogenesis / Ausgabe 1/2020
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-019-09690-0

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Pathological features of vessel co-option versus sprouting angiogenesis

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Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Prostatakarzinom: EU initiiert neues Screeningkonzept

Blasenkarzinom – Biomarker statt Zytologie?

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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Weitere Artikel der Ausgabe 1/2020

Vascular co-option in brain metastasis

Vessel co-option and resistance to anti-angiogenic therapy

Angiotropism, pericytic mimicry and extravascular migratory metastasis: an embryogenesis-derived program of tumor spread

Vessel co-option in glioblastoma: emerging insights and opportunities

Models and molecular mechanisms of blood vessel co-option by cancer cells

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Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Prostatakarzinom: EU initiiert neues Screeningkonzept

Blasenkarzinom – Biomarker statt Zytologie?

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Update Innere Medizin