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International Journal of Hematology

Erschienen in:

03.12.2019 | Progress in Hematology

Pathophysiology of chronic lymphocytic leukemia and human B1 cell development

verfasst von: Yoshikane Kikushige

Erschienen in: International Journal of Hematology | Ausgabe 5/2020

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Abstract

Chronic lymphocytic leukemia (CLL), the most frequent type of leukemia in adults, is a lymphoproliferative disease characterized by the clonal expansion of mature CD5⁺ B cells in peripheral blood, bone marrow, and secondary lymphoid tissues. Over the past decade, substantial advances have been made in understanding the pathogenesis of CLL, including the identification of recurrent mutations, and clarification of clonal architectures, transcriptome analyses, and the multistep leukemogenic process. The biology of CLL is now better understood. The present review focuses on recent insights into CLL leukemogenesis, emphasizing the role of genetic lesions, and the multistep process initiating from very immature hematopoietic stem cells. Finally, we also review progress in the study of human B1 B cells, the putative normal counterparts of CLL cells.

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Titel: Pathophysiology of chronic lymphocytic leukemia and human B1 cell development
verfasst von: Yoshikane Kikushige
Publikationsdatum: 03.12.2019
Verlag: Springer Singapore
Erschienen in: International Journal of Hematology / Ausgabe 5/2020
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-019-02788-7

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Pathophysiology of chronic lymphocytic leukemia and human B1 cell development

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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