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BMC Musculoskeletal Disorders

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Open Access 01.12.2016 | Research article

Patient and system factors of mortality after hip fracture: a scoping review

verfasst von: K. J. Sheehan, B. Sobolev, A. Chudyk, T. Stephens, P. Guy

Erschienen in: BMC Musculoskeletal Disorders | Ausgabe 1/2016

Abstract

Background

Several patient and health system factors were associated with the risk of death among patients with hip fracture. However, without knowledge of underlying mechanisms interventions to improve survival post hip fracture can only be designed on the basis of the found statistical associations.

Methods

We used the framework developed by Arksey and O’Malley and Levac et al. for synthesis of factors and mechanisms of mortality post low energy hip fracture in adults over the age of 50 years, published in English, between September 1, 2009 and October 1, 2014 and indexed in MEDLINE. Proposed mechanisms for reported associations were extracted from the discussion sections.

Results

We synthesized the evidence from 56 articles that reported on 35 patient and 9 system factors of mortality post hip fracture. For 21 factors we found proposed biological mechanisms for their association with mortality which included complications, comorbidity, cardiorespiratory function, immune function, bone remodeling and glycemic control.

Conclusions

The majority of patient and system factors of mortality post hip fracture were reported by only one or two articles and with no proposed mechanisms for their effects on mortality. Where reported, underlying mechanisms are often based on a single article and should be confirmed with further study. Therefore, one cannot be certain whether intervening on such factors may produce expected results.

Competing interests

Pierre Guy has received grants from the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada, the Canadian Foundation for Innovation and the British Columbia Specialists Services Committee for work around hip fracture care not related to this manuscript. He has also received fees from the BC Specialists Services Committee (for a provincial quality improvement project on redesign of hip fracture care) and from Stryker Orthopedics (as a product development consultant). He is a board member and shareholder in Traumis Surgical Systems Inc. and a board member for the Canadian Orthopedic Foundation. He also serves on the speakers’ bureaus of AO Trauma North America and Stryker Canada. Katie Jane Sheehan, Boris Sobolev, Trina Stephens and Anna Chudyk declare that they have no competing interests.

Authors’ contributions

All authors contributed to the conception and design of the review. In addition KJS, TS, AC contributed to the search development, identification of papers and data extraction. KJS, BS and PG contributed to the interpretation of the data extracted. KJS and SB drafted the manuscript. All authors critically revised the manuscript. All authors approved the final version for submission.

MESH

medical subject headings

What is previously known

Excess mortality persists for years post hip fracture.
Several patient and system factors have been associated with the risk of death in patients with hip fracture.
However underlying mechanisms of the found associations are rarely discussed.

What this study adds

We synthesized the evidence from 56 recent articles that reported on 35 patient and 9 system factors of mortality post hip fracture.
The majority of factors were reported with no proposed mechanisms for their effects on mortality. Where reported, underlying mechanisms are often based on a single article.
The proposed biological mechanisms include complications, comorbidity, cardiorespiratory function, immune function, bone remodeling and glycemic control.

Background

Hip fracture is a leading cause of injury related mortality in older adults [1]. Omsland and colleagues reported mortality rates five times higher in men and three times higher in women compared to the general population in the first year post fracture [2]. This excess mortality persists 10 years post fracture [2, 3].

The existing literature identifies patient and system factors associated with the risk of death among patients with hip fracture. However, no attempt has been made to synthesize this literature on the underlying mechanisms for these associations.

Without knowledge of mechanisms mediating an association, interventions to improve survival post hip fracture can only be designed on the basis of the reported statistical associations. We believe designing interventions should rely on knowledge about a modifiable factor with negative effect on survival. Where modifiable factors lie on the causal pathway between exposure and outcome determines the focus of an intervention.

Scoping reviews represent an approach to summarizing the range of evidence on a subject, to clarify a complex concept, and to help refine subsequent research questions for a full systematic review [4, 5]. This review contributes to the existing literature by synthesizing the evidence available on patient and system factors of mortality after hip fracture. To go beyond traditional reports, we extract and synthesize additional information on biological and hypothetical mechanisms for reported associations. More specifically, the aims of this review are 1) to identify patient and system factors of mortality after hip fracture, and 2) collate the description of proposed mechanisms for their associations with mortality.

Methods

The key elements of the scoping review framework include formulating the research question, identifying relevant studies, selecting studies from electronic database, charting the extracted data and collating, summarizing and reporting findings. We extend this framework by collecting information on the underlying mechanisms for found associations. We have followed to a widely recognized framework by Arksey and O’Malley [6] and recommendations of Levac et al. [5] for conducting and reporting scoping reviews. This scoping review synthesizes published literature and ethical approval was not required.

The population of interest is frail adults aged 50 years or older admitted to acute care with non-pathologic low energy hip fracture. Concepts of interest include both patient and system factors. The outcome of interest is mortality following usual care.

Study selection

One reviewer searched MEDLINE using the search terms “mortality” Medical Subject Headings [MeSH] AND “hip fracture” [MeSH] and screened studies for eligibility. Studies were first screened according to title and abstract with those that appeared suitable selected for a full-text review using standardized inclusion criteria (Table 1). Studies marked as ‘maybe for inclusion’ were screened by a second reviewer for eligibility.

Table 1

Inclusion criteria for the literature search

Term	Include
Study population	Men & women ≥50 years of age with non-pathological low energy hip fracture
Study design	0bservational studies
Factors	Patient and system factors of mortality
Associations	Estimates from regression analysis
Outcome	Mortality (in-hospital, 30 day, 12 month, >12 month)
Date	Between Sep 1, 2009 and Oct 1, 2014
Language	English
Geography	Worldwide

We included reports from 2009 or later to minimize the potential biasing effects of demographic aging [7‐9], surgical advancements [10], and changes in delivery of hip fracture care [11‐13]. Intervention-based studies were excluded as they do not reflect hip fracture mortality following usual care. Studies whose main independent variables were laboratory tests or operation type were also excluded as they were considered outside of the current scope of interest. Finally, only studies which conducted a regression analysis were included as regression analysis was deemed a proxy for adequate sample size [14].

Using a formal instrument, one reviewer extracted authors name, publication date, timing of assessment relative to the hip fracture event, length of follow up, patient and system factors from each article. The significance of statistical associations between the factors and mortality was derived from the 95 % confidence intervals reported in the articles. The proposed mechanisms for mortality were extracted from discussions by one reviewer. The accuracy of extraction was assessed by a second reviewer.

Collating, summarizing and reporting results

Patient and system factors of mortality studied in the reviewed articles are summarized in Tables 2, 3 and 4. Factors with a proposed mechanism of their effects on mortality are summarized in Tables 5 and 6 with indication whether the mechanisms is hypothetical.

Table 2

Articles studying mortality in relation to injury and complications

	Fracture type	Injury severity	Additional trauma	Shock	Complications	Cardiovascular complications	Decubitus ulcer	Gastrointestinal bleeding	Pulmonary complications	Clostridium difficile	Renal failure	Pneumonia	Delirium
Belmont 2014 [15]		√		√
Neuhaus 2013 [17]	√		√
Miller 2012 [22]						√
Gold 2012 [24]							√
Librero 2012 [23]		√
Tarazona-Santabalbina 2012 [47]													√*
Lee 2011 [62]													√
Miyanishi 2010 [63]					√
Vaseenon 2010 [65]	√*
Juliebo 2010 [66]
Rahme 2010 [55]								√			√
Lapcevic 2010 [57]									√		√
Juliebo 2010 [66]													√*
Berry 2009 [60]							√					√
Gulihar 2009 [41]										√
Among all	1	2	1	1	1	1	2	1	1	1	2	1	1

*no statistical association found

Table 3

Articles studying mortality in relation to demographic factors and comorbidity

	Age	Sex	Race	Preadmission residence	Functional status	Any comorbidity	Liver disease	Diabetes	Malignancy	Malnutrition	Low Body Mass Index*	Obesity	SecondaryHyperparathyroidism**	Cardiac disease	Cardiac arrhythmia	Congestive heart failure***	Coronary artery disease^¥	Myocardial infarction^§	Cerebrovascular accident^¶	Anemia	Cognitive impairment	Dementia
Belmont 2014 [15]		√												√
Neuhaus 2013 [17]	√	√				√									√
Williams 2013 [36]	√	√				√																√
Hagino 2013 [16]										√
Talsnes 2013 [37]						√
Uzoigwe 2013 [19]	√	√		√		√
Clement 2013 [42]						√
Daugaard 2012 [18]	√	√				√
Le-Wendling 2012 [20]	√	√	√
Librero 2012 [23]	√	√				√
Huddleston 2012 [44]		√														√		√				√
Adunsky 2012 [43]	√	√													√
Gupta 2012 [45]																		√
Valizadeh 2012 [46]	√	√****			√	√****
Tarazona-Santabalbina 2012 [47]	√	√			√	√															√
Pioli 2012 [48]					√
Sanz-Reig 2012 [49]					√	√							√									√
Vidan 2011 [25]	√				√	√																√
Koval 2011 [26]		√				√
Frost 2011 [27]	√	√				√	√									√
Kirkland 2011 [38]						√
Carretta 2011 [39]	√	√				√					√				√				√
Gulcelik 2011 [52]								√
Talsnes 2011 [53]	√	√				√
Baker 2011 [64]																						√
LeBlanc 2011 [70]	√
Holvik 2010 [54]				√		√
Kesmezacar 2010 [67]	√
Rahme 2010 [55]	√	√		√		√		√	√						√	√	√
Forte 2010 [56]	√		√			√
Lapcevic 2010 [57]	√	√					√		√	√						√						√
Miyanishi 2010 [63]											√											√
Juliebo 2010 [66]		√			√						√				√		√
Jamal 2010 [59]		√										√
Bjorgul 2010 [69]	√	√				√
Pereira 2010 [58]	√	√			√	√****		√											√
Vaseenon 2010 [65]		√
Berry 2009 [60]	√	√			√											√	√			√
Lefaivre 2009 [33]	√	√				√
Vidal 2009 [35]	√	√				√
Feng 2009 [68]						√
Among all	23	23	2	3	8	23	2	3	2	2	3	1	1	1	5	5	3	2	2	1	1	7

*Body mass index

** Secondary hyperparathyroidism

*** Congestive heart failure

****no statistical association found

^¥ Coronary artery disease

^§ Myocardial infarction

^¶ Cerebrovascular accident

Table 4

Articles studying mortality in relation to system factors

	Hospital volume	Surgeon volume	Nursing volume	July admit	General anesthetic	Intensive care admit	Short stay	Hospitalization delay	Surgical delay
Belmont 2014 [15]									√*
Li 2014 [61]								√	√
Uzoigwe 2013 [19]									√
Williams 2013 [36]							√		√
Neuman 2012 [21]					√
Pioli 2012 [48]									√
Vidal 2012 [50]								√	√*
Tarazona-Santabalbina 2012 [47]				√*					√*
Le-Wendling 2012 [20]						√
Sanz-Reig 2012 [49]									√*
Daugaard 2012 [18]									√
Koval 2011 [26]									√
Peleg 2011 [30]									√
Schilling 2011 [28]			√
Carretta 2011 [39]									√
Forte 2010 [56]	√	√
Kesmezacar 2010 [67]									√
Browne 2009 [34]	√*	√
Anderson 2009 [31]				√
Vidal 2009 [35]					√
Among all	1	2	1	1	2	1	1	2	9

*no statistical association found

Table 5

Proposed mechanisms and mediators for the mortality effect of patient factors

Factor	Mechanism	Mediator
Age	Aging reduces the reserve capacity necessary to cope with a double trauma of hip fracture and surgery [22, 37].	Hypothesis only
Age	The number of chronic conditions increases with age [47, 70].	Extent of comorbidity
Sex	Men present with more comorbidity than women [47, 54, 65, 68].	Extent of comorbidity
Sex	Men develop delirium [60], lung infection, pneumonia, and septicemia more often than women [54, 68].	Complications
Prefracture function	Patients with poorer pre-fracture ambulatory status often have reduced cardiorespiratory function compared to those with better status [68].	Cardiorespiratory function
	Patients with a high degree of dependency are more often delayed to admission than patients with a low degree of dependency [50].	Hospitalization delay
	Patients with poor pre-fracture ambulatory status are quickly placed in nursing homes while patients with better status wait in hospital for rehabilitation beds [36].	Length of stay
Preadmission residence	Institutionalized patients develop pneumonia and pressure ulcer more often than patients from community [54, 60].	Complications
Socioeconomic status	Patients with low socioeconomic status are more often delayed to admission than patients with high socioeconomic status [50].	Hospitalization delay
Clinical stability	Patients who are acutely unstable on admission are delayed to surgery more often than those who are stable [25, 39].	Surgical delay
Extent of comorbidity	Multiple comorbidities diminish reserves for stresses of surgery and delays recovery [37, 38].	Hypothesis only
	Patients with more comorbidity are delayed to surgery more often than those with less comorbidity [25, 48].	Surgical delay
	Patients with more comorbidity are quickly placed in nursing homes while patients with less comorbidity wait in hospital for rehabilitation beds [36].	Length of stay
Body composition	Patients with low BMI are more likely to develop adverse cardiac event post hip fracture surgery [66].	Complications
	Patients with low BMI are more likely to be frail [66] and have diminished reserves to cope with the stress of surgery [38].	Hypothesis only
	Patients with low BMI often have reduced cardiorespiratory function and a supressed immune system [38].	Immune response, Cardiorespiratory function
History of cerebrovascular accident	Patients with hemiplegia often have more comorbidity and poor pre-fracture ambulatory status [68].	Extent of comorbidity, Pre-fracture function
Dementia	Patients with dementia often have more comorbidity and poor pre-fracture ambulatory status [68].	Extent of comorbidity, Pre-fracture function
Diabetes	Diabetes may lead to poor bone remodeling post hip fracture [52].	Bone remodeling [77]
	Diabetes may lead to poor wound healing post hip fracture surgery [52].	Hypothesis only
	Patients with diabetes may have poor glycemic control leaving the body prone to infections and complications after surgery [52].	Glycemic control [78] Complications
Malnutrition	Patients with malnutrition often present with more comorbidity and poor pre-fracture ambulatory status.(16;38)	Extent of comorbidity, Pre-fracture function
Myocardial infarction	Patent foramen ovale allows procoagulant cell conjugates and fragments to pass directly from the venous to the arterial blood [37].	Hypothesis only
Secondary hyperparathyroidism	Patients with secondary hyperparathyroidism often have more comorbidity [51].	Extent of comorbidity
Secondary hyperparathyroidism	Secondary hyperparathyroidism leads to severely altered calcium homeostasis [32].	Calcium homeostasis

Table 6

Proposed mechanisms and mediators for the effect of system factors on mortality

Factor	Mechanism	Mediator
Hospital volume	Patients admitted to low volume hospitals are often delayed to surgery when compared to patients admitted to high volume hospitals [56].	Surgical delay
Nursing staff volume	Higher nurse staffing may prevent or allow early detection of complications [28].	Complications
	Higher nurse staffing improves operating room availability and shorten time to surgery [28].	Surgical delay
Surgeon volume	Low volume surgeons may not select appropriate procedure and preoperative planning, intraoperative technique and postoperative management [34].	Hypothesis only
Surgical delay	Patients who are delayed to surgery are exposed to inflammatory and hypercoagulable states for longer than those who are not delayed [71, 72].	Hypothesis only
Hospitalization delay	Patients may receive suboptimal care prior to admission and may develop pressure ulcers, thromboembolism, uncontrolled pain or delirium [50, 61].	Complications
Length of stay	Institutionalized patients have shorter hospital stay than patients from community [36].	Discharge destination
Admission month	Patients admitted in July may be exposed to lower staffing levels in holiday period [31].	Staffing volume

Results

Search results

The search produced 241 articles for initial title and abstract screening. Figure 1 shows the selection process which identified 56 articles used in this review. Among the selected articles, 21 reported on in-hospital mortality [15‐35], 4 reported on 30 day mortality [36‐39], 20 reported on 12 months mortality [40‐59], and 11 reported more than 12 month mortality [60‐70].

Patient factors of mortality

We identified 35 patient factors of mortality post hip fracture reported in the reviewed articles, Tables 2 and 3. The majority of factors were studied by only one or two studies included in this review. There is a general consensus in the literature that mortality is associated with age, sex, comorbidity, functional status, dementia, arrhythmia and congestive heart failure. We noted conflicting reports for the association between mortality and both fracture type [17, 65] and delirium [47, 62, 66].

For 14 factors we found a proposed mechanism of their effects on mortality, Table 5. Biological mechanisms included comorbidity [47, 70], cardiorespiratory function [68], immune function [38], bone remodeling [52], glycemic control [52], and calcium homeostasis [32]. Non-biological mechanisms included hospitalization delay [50], surgical delay [25, 48] and length of stay [36]. Some proposed included hypothetical mediators, such as reduced reserve capacity [22, 37], a patent foramen ovale [37] and reduced wound healing [52]. Fig. 2 shows two examples of the mechanisms proposed for patient factors in the reviewed articles. First, the onset of complications mediates the effect of cardiorespiratory function on mortality [63]. Second, a hypothetical reduction in reserve capacity mediates the mortality effect of age and extent of comorbidity [22, 37].

System factors of mortality

In the reviewed articles, we identified 9 system factors of mortality post hip fracture including hospitalization delay, July admission, surgical delay, anaesthetic type, intensive care admission, hospital volume, surgeon volume, nursing volume and length of stay, Table 4. There is no consensus in the literature on system factors of mortality. The most studied factor was surgical delay (9 articles). However, the association of mortality with surgical delays is disputed by reports of no association [15, 47, 49, 50]. We also noted conflicting reports for the association between mortality and both July admission and hospital volume. The other factors were studied by only one or two studies included in this review.

For 7 factors we found a proposed mechanism of their effects on mortality, Table 6. Complications were proposed as a biological mechanism for the mortality effect of nursing staff volume [28] and hospitalization delay [50, 61]. Non-biological mechanisms included surgical delay [28], staffing volume [31] and discharge destination [36]. Some proposed included hypothetical mediators, such as, exposure to inflammatory and hypercoagulable states [71, 72] and inappropriate planning, technique or management [34].

Discussion

The purpose of this review was to synthesize the information available on proposed mechanisms for reported associations between patient and system factors and mortality after hip fracture. The articles included in this review point to plausible mediators in the biological mechanisms for mortality post fracture: complications, comorbidity, cardiorespiratory function, immune function, bone remodeling and glycemic control. For example, exposure to immobilization and inflammatory states is the proposed mechanism mediating the mortality effect of hospitalization delay [71, 72]. As argued elsewhere, prolonged immobilization leads to potentially fatal complications such as pulmonary embolism and pneumonia while prolonged hypercoagulable inflammation leads to potentially fatal complications including stroke and myocardial infarction [73].

A hypothetical reduction in reserve capacity, whereby a patient cannot withstand the stress of trauma and their pre-existing comorbidity [38], was proposed as a mechanism for the mortality effect of comorbidity [22, 37]. It seems plausible, because numerous studies associated mortality with coexisting arrhythmia, congestive heart failure, coronary artery disease, myocardial infarction, anemia and cerebrovascular accident. As noted elsewhere, patients undergoing hip fracture surgery require the reserve capacity to withstand the cardiovascular depressant effect of anaesthesia [74]. For those who survive beyond the short-term, patients with cardiovascular disease more often present with reduced reserve exercise capacity [75] compromising their rehabilitation potential and placing them at greater risk of dependency, complications and death [76].

This is the first scoping review to synthesize the proposed biological and hypothetical mechanisms for patient and system factors of mortality following hip fracture. Such synthesis represents a first step towards transparency about underlying assumptions when informing policy on potential interventions to improve survival in this vulnerable population.

This review is not without limitations. In contrast to a systematic review, where literature is critically appraised on the methodology, we assess the reviewed articles only according to the presence of proposed mechanisms for the reported associations. This is a common approach in scoping reviews where the purpose is to collate the evidence on a topic of interest. [5] The search strategy was restricted to one database over a 5 year period preceding the review development to minimize the potential biasing effects of surgical advancements [10], and changes in delivery of hip fracture care [11‐13]. We excluded articles reporting outcomes of interventions as they do not reflect hip fracture mortality resulting from usual care. These restrictions may result in lacking some articles both on factors of mortality and proposed mechanisms.

Conclusions

We synthesized proposed mechanisms for reported associations between patient and system factors and mortality after hip fracture. We identified complications, comorbidity, cardiorespiratory function, immune function and bone remodeling and glycemic control as plausible mediators in the biological mechanisms for mortality post fracture. However, we found that the majority of patient and system factors of mortality post hip fracture were reported by only one or two articles and with no proposed mechanisms for their effects on mortality. Where reported, underlying mechanisms are often based on a single article and should be confirmed with further study. Therefore, one cannot be certain whether intervening on such factors may produce expected results.

Not applicable.

Availability of data and materials

Articles were identified in MEDLINE. All articles included in the final review are identified in the reference list. Access to full text for each article is dependent on journal and institutional constraints.

Acknowledgements

Not applicable.

Funding

This research was funded by the Centre for Clinical Epidemiology and Evaluation and the Centre for Hip Health and Mobility, Vancouver, Canada. The funders had no role in the design of the review, the data collection, analysis or interpretation of the data, or in writing the manuscript.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Competing interests

Authors’ contributions

Panula J, Pihlajamaki H, Mattila VM, et al. Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study. BMC Musculoskelet Disord. 2011;12:105.CrossRefPubMedPubMedCentral

Omsland TK, Emaus N, Tell GS, et al. Mortality following the first hip fracture in Norwegian women and men (1999–2008). A NOREPOS study. Bone. 2014;63:81–6.CrossRefPubMed

Haentjens P, Magaziner J, Colon-Emeric CS, et al. Meta-analysis: excess mortality after hip fracture among older women and men. Ann Intern Med. 2010;152(6):380–90.CrossRefPubMedPubMedCentral

Davis K, Drey N, Gould D. What are scoping studies? A review of the nursing literature. Int J Nurs Stud. 2009;46(10):1386–400.CrossRefPubMed

Levac D, Colquhoun H, O'Brien KK. Scoping studies: advancing the methodology. Implement Sci. 2010;5:69.CrossRefPubMedPubMedCentral

Arksey H, O'Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 2005;8:19–32.CrossRef

Gullberg B, Johnell O, Kanis JA. World-wide projections for hip fracture. Osteoporos Int. 1997;7(5):407–13.CrossRefPubMed

Baker PN, Salar O, Ollivere BJ, et al. Evolution of the hip fracture population: time to consider the future? A retrospective observational analysis. BMJ Open. 2014;4(4):e004405.CrossRefPubMedPubMedCentral

Cooper C, Campion G, Melton III LJ. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992;2(6):285–9.CrossRefPubMed

10.

Leung F, Blauth M, Bavonratanavech S. Surgery for fragility hip fracture-streamlining the process. Osteoporos Int. 2010;21 Suppl 4:519–21.CrossRefPubMedCentral

11.

Auais M, Morin S, Nadeau L, et al. Changes in frailty-related characteristics of the hip fracture population and their implications for healthcare services: evidence from Quebec, Canada. Osteoporos Int. 2013;24(10):2713–24.CrossRefPubMed

12.

Barrett B, Way C, McDonald J, et al. Hospital utilization, efficiency and access to care during and shortly after restructuring acute care in Newfoundland and Labrador. J Health Serv Res Policy. 2005;10 Suppl 2:S2–7.CrossRef

13.

Suhm N, Kaelin R, Studer P, et al. Orthogeriatric care pathway: a prospective survey of impact on length of stay, mortality and institutionalisation. Arch Orthop Trauma Surg. 2014;134(9):1261–9.CrossRefPubMed

14.

Kelley K, Maxwell SE. Sample size for multiple regression: obtaining regression coefficients that are accurate, not simply significant. Psychol Methods. 2003;8(3):305–21.CrossRefPubMed

15.

Belmont Jr PJ, Garcia EJ, Romano D, et al. Risk factors for complications and in-hospital mortality following hip fractures: a study using the National Trauma Data Bank. Arch Orthop Trauma Surg. 2014;134(5):597–604.CrossRefPubMed

16.

Hagino T, Ochiai S, Watanabe Y, et al. Hyponatremia at admission is associated with in-hospital death in patients with hip fracture. Arch Orthop Trauma Surg. 2013;133(4):507–11.CrossRefPubMed

17.

Neuhaus V, King J, Hageman MG, et al. Charlson comorbidity indices and in-hospital deaths in patients with hip fractures. Clin Orthop Relat Res. 2013;471(5):1712–9.CrossRefPubMedPubMedCentral

18.

Daugaard CL, Jorgensen HL, Riis T, et al. Is mortality after hip fracture associated with surgical delay or admission during weekends and public holidays? A retrospective study of 38,020 patients. Acta Orthop. 2012;83(6):609–13.CrossRefPubMedPubMedCentral

19.

Uzoigwe CE, Burnand HG, Cheesman CL, et al. Early and ultra-early surgery in hip fracture patients improves survival. Injury. 2013;44(6):726–9.CrossRefPubMed

20.

Le-Wendling L, Bihorac A, Baslanti TO, et al. Regional anesthesia as compared with general anesthesia for surgery in geriatric patients with hip fracture: does it decrease morbidity, mortality, and health care costs? Results of a single-centered study. Pain Med. 2012;13(7):948–56.CrossRefPubMedPubMedCentral

21.

Neuman MD, Silber JH, Elkassabany NM, et al. Comparative effectiveness of regional versus general anesthesia for hip fracture surgery in adults. Anesthesiology. 2012;117(1):72–92.CrossRefPubMed

22.

Miller AG, Bercik MJ, Ong A. Nonagenarian hip fracture: treatment and complications. J Trauma Acute Care Surg. 2012;72(5):1411–5.CrossRefPubMed

23.

Librero J, Peiro S, Leutscher E, et al. Timing of surgery for hip fracture and in-hospital mortality: a retrospective population-based cohort study in the Spanish National Health System. BMC Health Serv Res. 2012;12:15.CrossRefPubMedPubMedCentral

24.

Gold A, Sever R, Lerman Y, et al. Admission Norton scale scores (ANSS) and postoperative complications following hip fracture surgery in the elderly. Arch Gerontol Geriatr. 2012;55(1):173–6.CrossRefPubMed

25.

Vidan MT, Sanchez E, Gracia Y, et al. Causes and effects of surgical delay in patients with hip fracture: a cohort study. Ann Intern Med. 2011;155(4):226–33.CrossRefPubMed

26.

Koval KJ, Rust CL, Spratt KF. The effect of hospital setting and teaching status on outcomes after hip fracture. Am J Orthop (Belle Mead NJ). 2011;40(1):19–28.

27.

Frost SA, Nguyen ND, Black DA, et al. Risk factors for in-hospital post-hip fracture mortality. Bone. 2011;49(3):553–8.CrossRefPubMed

28.

Schilling P, Goulet JA, Dougherty PJ. Do higher hospital-wide nurse staffing levels reduce in-hospital mortality in elderly patients with hip fractures: a pilot study. Clin Orthop Relat Res. 2011;469(10):2932–40.CrossRefPubMedPubMedCentral

29.

Barba R, Martinez JM, Zapatero A, et al. Mortality and complications in very old patients (90+) admitted to departments of internal medicine in Spain. Eur J Intern Med. 2011;22(1):49–52.CrossRefPubMed

30.

Peleg K, Savitsky B, Yitzhak B, et al. Different reimbursement influences surviving of hip fracture in elderly patients. Injury. 2011;42(2):128–32.CrossRefPubMed

31.

Anderson KL, Koval KJ, Spratt KF. Hip fracture outcome: is there a “July effect”? Am J Orthop (Belle Mead NJ). 2009;38(12):606–11.

32.

Fisher A, Goh S, Srikusalanukul W, et al. Elevated serum PTH is independently associated with poor outcomes in older patients with hip fracture and vitamin D inadequacy. Calcif Tissue Int. 2009;85(4):301–9.CrossRefPubMed

33.

Lefaivre KA, Macadam SA, Davidson DJ, et al. Length of stay, mortality, morbidity and delay to surgery in hip fractures. J Bone Joint Surg Br. 2009;91(7):922–7.CrossRefPubMed

34.

Browne JA, Pietrobon R, Olson SA. Hip fracture outcomes: does surgeon or hospital volume really matter? J Trauma. 2009;66(3):809–14.CrossRefPubMed

35.

Vidal EI, Moreira-Filho DC, Coeli CM, et al. Hip fracture in the elderly: does counting time from fracture to surgery or from hospital admission to surgery matter when studying in-hospital mortality? Osteoporos Int. 2009;20(5):723–9.CrossRefPubMed

36.

Williams N, Hardy BM, Tarrant S, et al. Changes in hip fracture incidence, mortality and length of stay over the last decade in an Australian major trauma centre. Arch Osteoporos. 2013;8(1–2):150.CrossRefPubMed

37.

Talsnes O, Vinje T, Gjertsen JE, et al. Perioperative mortality in hip fracture patients treated with cemented and uncemented hemiprosthesis: a register study of 11,210 patients. Int Orthop. 2013;37(6):1135–40.CrossRefPubMedPubMedCentral

38.

Kirkland LL, Kashiwagi DT, Burton MC, et al. The Charlson Comorbidity Index Score as a predictor of 30-day mortality after hip fracture surgery. Am J Med Qual. 2011;26(6):461–7.CrossRefPubMed

39.

Carretta E, Bochicchio V, Rucci P, et al. Hip fracture: effectiveness of early surgery to prevent 30-day mortality. Int Orthop. 2011;35(3):419–24.CrossRefPubMedPubMedCentral

40.

Ho WW, Kwan Dai DL, Liu KW, et al. To investigate the effect and cost-effectiveness of implementing an orthogeriatric intervention for elderly patients with acute hip fracture: the experience in Hong Kong. J Am Geriatr Soc. 2009;57(11):2153–4.CrossRefPubMed

41.

Gulihar A, Nixon M, Jenkins D, et al. Clostridium difficile in hip fracture patients: prevention, treatment and associated mortality. Injury. 2009;40(7):746–51.CrossRefPubMed

42.

Clement ND, Green K, Murray N, et al. Undisplaced intracapsular hip fractures in the elderly: predicting fixation failure and mortality. A prospective study of 162 patients. J Orthop Sci. 2013;18(4):578–85.CrossRefPubMed

43.

Adunsky A, Arad M, Koren-Morag N, et al. Increased 1-year mortality rates among elderly hip fracture patients with atrial fibrillation. Aging Clin Exp Res. 2012;24(3):233–8.CrossRefPubMed

44.

Huddleston JM, Gullerud RE, Smither F, et al. Myocardial infarction after hip fracture repair: a population-based study. J Am Geriatr Soc. 2012;60(11):2020–6.PubMedPubMedCentral

45.

Gupta BP, Huddleston JM, Kirkland LL, et al. Clinical presentation and outcome of perioperative myocardial infarction in the very elderly following hip fracture surgery. J Hosp Med. 2012;7(9):713–6.CrossRefPubMed

46.

Valizadeh M, Mazloomzadeh S, Golmohammadi S, et al. Mortality after low trauma hip fracture: a prospective cohort study. BMC Musculoskelet Disord. 2012;13:143.CrossRefPubMedPubMedCentral

47.

Tarazona-Santabalbina FJ, Belenguer-Varea A, Rovira-Daudi E, et al. Early interdisciplinary hospital intervention for elderly patients with hip fractures : functional outcome and mortality. Clinics (Sao Paulo). 2012;67(6):547–56.CrossRef

48.

Pioli G, Lauretani F, Davoli ML, et al. Older people with hip fracture and IADL disability require earlier surgery. J Gerontol A Biol Sci Med Sci. 2012;67(11):1272–7.CrossRefPubMed

49.

Sanz-Reig J, Lizaur-Utrilla A, Serna-Berna R. Outcomes in nonagenarians after hemiarthroplasty for femoral neck fracture. A prospective matched cohort study. Hip Int. 2012;22(1):113–8.CrossRefPubMed

50.

Vidal E, Moreira-Filho D, Pinheiro R, et al. Delay from fracture to hospital admission: a new risk factor for hip fracture mortality? Osteoporos Int. 2012;23(12):2847–53.CrossRefPubMed

51.

Madsen CM, Jorgensen HL, Lind B, et al. Secondary hyperparathyroidism and mortality in hip fracture patients compared to a control group from general practice. Injury. 2012;43(7):1052–7.CrossRefPubMed

52.

Gulcelik NE, Bayraktar M, Caglar O, et al. Mortality after hip fracture in diabetic patients. Exp Clin Endocrinol Diabetes. 2011;119(7):414–8.CrossRefPubMed

53.

Talsnes O, Hjelmstedt F, Dahl OE, et al. Clinical and biochemical prediction of early fatal outcome following hip fracture in the elderly. Int Orthop. 2011;35(6):903–7.CrossRefPubMedPubMedCentral

54.

Holvik K, Ranhoff AH, Martinsen MI, et al. Predictors of mortality in older hip fracture inpatients admitted to an orthogeriatric unit in Oslo, Norway. J Aging Health. 2010;22(8):1114–31.CrossRefPubMed

55.

Rahme E, Kahn SR, Dasgupta K, et al. Short-term mortality associated with failure to receive home care after hemiarthroplasty. CMAJ. 2010;182(13):1421–6.CrossRefPubMedPubMedCentral

56.

Forte ML, Virnig BA, Swiontkowski MF, et al. Ninety-day mortality after intertrochanteric hip fracture: does provider volume matter? J Bone Joint Surg Am. 2010;92(4):799–806.CrossRefPubMed

57.

Lapcevic WA, French DD, Campbell RR. All-cause mortality rates of hip fractures treated in the VHA: do they differ from Medicare facilities? J Am Med Dir Assoc. 2010;11(2):116–9.CrossRefPubMed

58.

Pereira SR, Puts MT, Portela MC, et al. The impact of prefracture and hip fracture characteristics on mortality in older persons in Brazil. Clin Orthop Relat Res. 2010;468(7):1869–83.CrossRefPubMedPubMedCentral

59.

Jamal SY, Umer M, Khan A, et al. Functional outcome, mortality and in-hospital complications of operative treatment in elderly patients with hip fractures in the developing world. Int Orthop. 2010;34(3):431–5.CrossRef

60.

Berry SD, Samelson EJ, Bordes M, et al. Survival of aged nursing home residents with hip fracture. J Gerontol A Biol Sci Med Sci. 2009;64(7):771–7.CrossRefPubMed

61.

Li Y, Lin J, Wang P, et al. Effect of time factors on the mortality in brittle hip fracture. J Orthop Surg Res. 2014;9:37.CrossRefPubMedPubMedCentral

62.

Lee KH, Ha YC, Lee YK, et al. Frequency, risk factors, and prognosis of prolonged delirium in elderly patients after hip fracture surgery. Clin Orthop Relat Res. 2011;469(9):2612–20.CrossRefPubMedPubMedCentral

63.

Miyanishi K, Jingushi S, Torisu T. Mortality after hip fracture in Japan: the role of nutritional status. J Orthop Surg (Hong Kong). 2010;18(3):265–70.

64.

Baker NL, Cook MN, Arrighi HM, et al. Hip fracture risk and subsequent mortality among Alzheimer’s disease patients in the United Kingdom, 1988–2007. Age Ageing. 2011;40(1):49–54.CrossRefPubMed

65.

Vaseenon T, Luevitoonvechkij S, Wongtriratanachai P, et al. Long-term mortality after osteoporotic hip fracture in Chiang Mai, Thailand. J Clin Densitom. 2010;13(1):63–7.CrossRefPubMed

66.

Juliebo V, Krogseth M, Skovlund E, et al. Medical treatment predicts mortality after hip fracture. J Gerontol A Biol Sci Med Sci. 2010;65(4):442–9.CrossRefPubMed

67.

Kesmezacar H, Ayhan E, Unlu MC, et al. Predictors of mortality in elderly patients with an intertrochanteric or a femoral neck fracture. J Trauma. 2010;68(1):153–8.CrossRefPubMed

68.

Feng M, Zhang J, Shen H, et al. Predictors of prognosis for elderly patients with poststroke hemiplegia experiencing hip fractures. Clin Orthop Relat Res. 2009;467(11):2970–8.CrossRefPubMedPubMedCentral

69.

Bjorgul K, Novicoff WM, Saleh KJ. American Society of Anesthesiologist Physical Status score may be used as a comorbidity index in hip fracture surgery. J Arthroplasty. 2010;25(6 Suppl):134–7.CrossRefPubMed

70.

LeBlanc ES, Hillier TA, Pedula KL, et al. Hip fracture and increased short-term but not long-term mortality in healthy older women. Arch Intern Med. 2011;171(20):1831–7.CrossRefPubMedPubMedCentral

71.

Beloosesky Y, Grinblat J, Pirotsky A. Different C-reactive protein kinetics in post-operative hip-fractured geriatric patients with and without complications. Gerontology. 2004;50(4):216–22.CrossRefPubMed

72.

Beloosesky Y, Hendel D, Weiss A, et al. Cytokines and C-reactive protein production in hip-fracture-operated elderly patients. J Gerontol A Biol Sci Med Sci. 2007;62(4):420–6.CrossRefPubMed

73.

Hip Fracture Accelerated Surgical Treatment and Care Track (HIP ATTACK) investigators. Accelerated careversus standard care among patients with hip fracture: the HIP ATTACK pilot trial. CMAJ 2014;186:E52–E60.

74.

Loushin M. The effects of anesthetic agents on cardiac function. In: Iaizzo P, editor. Handbook of Cardiac Anatomy, Physiology, and Devices. Totowa, NJ: Humana Press; 2005. p. 171–80.

75.

Gulati M, Pandey DK, Arnsdorf MF, et al. Exercise capacity and the risk of death in women: the St James Women Take Heart Project. Circulation. 2003;108(13):1554–9.CrossRefPubMed

76.

Schrack JA, Simonsick EM, Ferrucci L. The energetic pathway to mobility loss: an emerging new framework for longitudinal studies on aging. J Am Geriatr Soc. 2010;58 Suppl 2:S329–36.CrossRefPubMedPubMedCentral

77.

Watts NB. Clinical utility of biochemical markers of bone remodeling. Clin Chem. 1999;45(8 Pt 2):1359–68.PubMed

78.

King Jr JT, Goulet JL, Perkal MF, et al. Glycemic control and infections in patients with diabetes undergoing noncardiac surgery. Ann Surg. 2011;253(1):158–65.CrossRefPubMed

Titel: Patient and system factors of mortality after hip fracture: a scoping review
verfasst von: K. J. Sheehan
B. Sobolev
A. Chudyk
T. Stephens
P. Guy
Publikationsdatum: 01.12.2016
Verlag: BioMed Central
Erschienen in: BMC Musculoskeletal Disorders / Ausgabe 1/2016
Elektronische ISSN: 1471-2474
DOI: https://doi.org/10.1186/s12891-016-1018-7

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Patient and system factors of mortality after hip fracture: a scoping review

Abstract

Background

Methods

Results

Conclusions

Competing interests

Authors’ contributions

What is previously known

What this study adds

Background

Methods

Study selection

Collating, summarizing and reporting results

Results

Search results

Patient factors of mortality

System factors of mortality

Discussion

Conclusions

Availability of data and materials

Acknowledgements

Funding

Competing interests

Authors’ contributions

Arthropedia

Neu im Fachgebiet Orthopädie und Unfallchirurgie

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Update Orthopädie und Unfallchirurgie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Competing interests

Authors’ contributions

What is previously known

What this study adds

Background

Methods

Study selection

Collating, summarizing and reporting results

Results

Search results

Patient factors of mortality

System factors of mortality

Discussion

Conclusions

Ethical approval and consent to participate

Consent for publication

Availability of data and materials

Acknowledgements

Funding

Competing interests

Authors’ contributions

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