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Clinical Rheumatology

Erschienen in:

01.09.2009 | Brief Report

Patients treated by tegaserod for irritable bowel syndrome with constipation showed significant improvement in fibromyalgia symptoms. A pilot study

verfasst von: Tatiana Reitblat, Doron Zamir, Ilia Polishchuck, Galina Novochatko, Stephen Malnick, Leonid Kalichman

Erschienen in: Clinical Rheumatology | Ausgabe 9/2009

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Abstract

The symptoms of irritable bowel syndrome (IBS) are commonly seen in fibromyalgia (FM) patients. This study aimed to evaluate the effect of 5-hydroxytryptamin-4 receptor partial agonist (tegaserod) on the symptoms of FM among the patients who receive the medicine because of IBS. Forty-one female patients with IBS and constipation, which were subjects to tegaserod treatment, were examined by rheumatologist and 14 were found to suffer from FM. The fibromyalgia impact questionnaire (FIQ) and clinical examination were done before tegaserod treatment and 1 month after. The IBS status, the total FIQ score, the number of tender points and pain in tender points were lowered significantly after the treatment (p < 0.001 for all variables). The results of this pilot study provide the preliminary evidence that FM patients can benefit from treatment by 5-hydroxytryptamin-4 receptor partial agonist. Additional studies are needed to support this conclusion.

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Titel: Patients treated by tegaserod for irritable bowel syndrome with constipation showed significant improvement in fibromyalgia symptoms. A pilot study
verfasst von: Tatiana Reitblat
Doron Zamir
Ilia Polishchuck
Galina Novochatko
Stephen Malnick
Leonid Kalichman
Publikationsdatum: 01.09.2009
Verlag: Springer-Verlag
Erschienen in: Clinical Rheumatology / Ausgabe 9/2009
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-009-1194-z

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