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Erschienen in: Annals of Hematology 6/2014

01.06.2014 | Original Article

Patients with primary diffuse large B-cell lymphoma of female genital tract have high risk of central nervous system relapse

verfasst von: Xin-xin Cao, Jian Li, Wei Zhang, Ming-hui Duan, Ti Shen, Dao-bin Zhou

Erschienen in: Annals of Hematology | Ausgabe 6/2014

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Abstract

The objective of this study was to evaluate retrospectively the clinical characteristics, treatments, and outcomes of patients with primary diffuse large B-cell lymphoma (DLBCL) of the female genital tract. The basic characteristics, treatments, and outcomes of six patients diagnosed with primary DLBCL of the female genital tract, including the ovary, uterine cervix, and vagina, treated in our hospital between 2000 and 2012, were analyzed retrospectively. Seven of 323 (2.2 %) newly diagnosed DLBCLs were diagnosed as primary female genital tract DLBCL. Six patients with complete medical data were included in the analysis. The median age at diagnosis was 52.5 years (range 20–65). The presenting symptoms included abnormal vaginal bleeding, increased vaginal discharge, abdominal fullness, and abdominal pain. Two patients had stage IE disease and four patients had stage IIE disease. Treatment included chemotherapy only in five patients, and combined chemotherapy and localized radiation in one patient. After a median follow-up of 58 months, four patients showed relapse in the central nervous system and two had died from progressive disease. The median progression-free survival was 27 months and the median overall survival for this group has not been reached. Patients with primary female genital tract DLBCL may have poor outcomes and a high risk of central nervous system relapse. Central nervous system prophylaxis might be considered in addition to systemic chemotherapy for DLBCL of the female genital tract.
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Metadaten
Titel
Patients with primary diffuse large B-cell lymphoma of female genital tract have high risk of central nervous system relapse
verfasst von
Xin-xin Cao
Jian Li
Wei Zhang
Ming-hui Duan
Ti Shen
Dao-bin Zhou
Publikationsdatum
01.06.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Annals of Hematology / Ausgabe 6/2014
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-013-2003-y

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